Data collected in psychiatry and related fields are complex because outcomes are rarely directly observed, there are multiple correlated repeated measures within individuals, there is natural heterogeneity in treatment responses and in other characteristics in the populations. Simple statistical methods do not work well with such data. More advanced statistical methods capture the data complexity better, but are difficult to apply appropriately and correctly by investigators who do not have advanced training in statistics. This book presents, at a non-technical level, several approaches for the analysis of correlated data: mixed models for continuous and categorical outcomes, nonparametric methods for repeated measures and growth mixture models for heterogeneous trajectories over time. Separate chapters are devoted to techniques for multiple comparison correction, analysis in the presence of missing data, adjustment for covariates, assessment of mediator and moderator effects, study design and sample size considerations. The focus is on the assumptions of each method, applicability and interpretation rather than on technical details. Features Provides an overview of intermediate to advanced statistical methods applied to psychiatry. Takes a non-technical approach with mathematical details kept to a minimum. Includes lots of detailed examples from published studies in psychiatry and related fields. Software programs, data sets and output are available on a supplementary website. The intended audience are applied researchers with minimal knowledge of statistics, although the book could also benefit collaborating statisticians. The book, together with the online materials, is a valuable resource aimed at promoting the use of appropriate statistical methods for the analysis of repeated measures data. Ralitza Gueorguieva is a Senior Research Scientist at the Department of Biostatistics, Yale School of Public Health. She has more than 20 years experience in statistical methodology development and collaborations with psychiatrists and other researchers, and is the author of over 130 peer-reviewed publications.

Data collected in psychiatry and related fields are complex because outcomes are rarely directly observed, there are multiple correlated repeated measures within individuals, there is natural heterogeneity in treatment responses and in other characteristics in the populations. Simple statistical methods do not work well with such data. More advanced statistical methods capture the data complexity better, but are difficult to apply appropriately and correctly by investigators who do not have advanced training in statistics. This book presents, at a non-technical level, several approaches for the analysis of correlated data: mixed models for continuous and categorical outcomes, nonparametric methods for repeated measures and growth mixture models for heterogeneous trajectories over time. Separate chapters are devoted to techniques for multiple comparison correction, analysis in the presence of missing data, adjustment for covariates, assessment of mediator and moderator effects, study design and sample size considerations. The focus is on the assumptions of each method, applicability and interpretation rather than on technical details. Features Provides an overview of intermediate to advanced statistical methods applied to psychiatry. Takes a non-technical approach with mathematical details kept to a minimum. Includes lots of detailed examples from published studies in psychiatry and related fields. Software programs, data sets and output are available on a supplementary website. The intended audience are applied researchers with minimal knowledge of statistics, although the book could also benefit collaborating statisticians. The book, together with the online materials, is a valuable resource aimed at promoting the use of appropriate statistical methods for the analysis of repeated measures data. Ralitza Gueorguieva is a Senior Research Scientist at the Department of Biostatistics, Yale School of Public Health. She has more than 20 years experience in statistical methodology development and collaborations with psychiatrists and other researchers, and is the author of over 130 peer-reviewed publications.

This volume, Statistical Methods in Psychiatry Research and SPSS, now going into its second edition, has been helping psychiatrists expand their knowledge of statistical methods and fills the gaps in their applications as well as introduces data analysis software. It addresses the statistical needs of physicians and presents a simplified approach. The book emphasizes the classification of fundamental statistical methods in psychiatry research that are precise and simple. Professionals in the field of mental health and allied subjects without any mathematical background will easily understand all the relevant statistical methods and carry out the analysis and interpret the results in their respective field without consulting any statistician. This new volume has over 100 pages of new material, including several new appendixes. The sequence of the chapters, the sections within the chapters, the subsections within the sections, and the points within the subsections have all been arranged to help professionals in classification refine their knowledge in statistical methods and fills the gaps.

Epilepsy research promises new treatments and insights into brain function, but statistics and machine learning are paramount for extracting meaning from data and enabling discovery. Statistical Methods in Epilepsy provides a comprehensive introduction to statistical methods used in epilepsy research. Written in a clear, accessible style by leading authorities, this textbook demystifies introductory and advanced statistical methods, providing a practical roadmap that will be invaluable for learners and experts alike. Topics include a primer on version control and coding, pre-processing of imaging and electrophysiological data, hypothesis testing, generalized linear models, survival analysis, network analysis, time-series analysis, spectral analysis, spatial statistics, unsupervised and supervised learning, natural language processing, prospective trial design, pharmacokinetic and pharmacodynamic modeling, and randomized clinical trials. Features: Provides a comprehensive introduction to statistical methods employed in epilepsy research Divided into four parts: Basic Processing Methods for Data Analysis; Statistical Models for Epilepsy Data Types; Machine Learning Methods; and Clinical Studies Covers methodological and practical aspects, as well as worked-out examples with R and Python code provided in the online supplement Includes contributions by experts in the field https://github.com/sharon-chiang/Statistics-Epilepsy-Book/ The handbook targets clinicians, graduate students, medical students, and researchers who seek to conduct quantitative epilepsy research. The topics covered extend broadly to quantitative research in other neurological specialties and provide a valuable reference for the field of neurology.

This book has been prepared to help psychiatrists expand their knowledge of statistical methods and fills the gaps in their applications as well as introduces data analysis software. The book emphasizes the classification of fundamental statistical methods in psychiatry research that are precise and simple. Professionals in the field of mental heal

Survival Analysis with Interval-Censored Data: A Practical Approach with Examples in R, SAS, and BUGS provides the reader with a practical introduction into the analysis of interval-censored survival times. Although many theoretical developments have appeared in the last fifty years, interval censoring is often ignored in practice. Many are unaware of the impact of inappropriately dealing with interval censoring. In addition, the necessary software is at times difficult to trace. This book fills in the gap between theory and practice. Features: -Provides an overview of frequentist as well as Bayesian methods. -Include a focus on practical aspects and applications. -Extensively illustrates the methods with examples using R, SAS, and BUGS. Full programs are available on a supplementary website. The authors: Kris Bogaerts is project manager at I-BioStat, KU Leuven. He received his PhD in science (statistics) at KU Leuven on the analysis of interval-censored data. He has gained expertise in a great variety of statistical topics with a focus on the design and analysis of clinical trials. Arnošt Komárek is associate professor of statistics at Charles University, Prague. His subject area of expertise covers mainly survival analysis with the emphasis on interval-censored data and classification based on longitudinal data. He is past chair of the Statistical Modelling Society and editor of Statistical Modelling: An International Journal. Emmanuel Lesaffre is professor of biostatistics at I-BioStat, KU Leuven. His research interests include Bayesian methods, longitudinal data analysis, statistical modelling, analysis of dental data, interval-censored data, misclassification issues, and clinical trials. He is the founding chair of the Statistical Modelling Society, past-president of the International Society for Clinical Biostatistics, and fellow of ISI and ASA.

The book's website (with databases and other support materials) can be accessed here. Praise for the Second Edition: The second edition introduces an especially broad set of statistical methods ... As a lecturer in both transportation and marketing research, I find this book an excellent textbook for advanced undergraduate, Master’s and Ph.D. students, covering topics from simple descriptive statistics to complex Bayesian models. ... It is one of the few books that cover an extensive set of statistical methods needed for data analysis in transportation. The book offers a wealth of examples from the transportation field. —The American Statistician Statistical and Econometric Methods for Transportation Data Analysis, Third Edition offers an expansion over the first and second editions in response to the recent methodological advancements in the fields of econometrics and statistics and to provide an increasing range of examples and corresponding data sets. It describes and illustrates some of the statistical and econometric tools commonly used in transportation data analysis. It provides a wide breadth of examples and case studies, covering applications in various aspects of transportation planning, engineering, safety, and economics. Ample analytical rigor is provided in each chapter so that fundamental concepts and principles are clear and numerous references are provided for those seeking additional technical details and applications. New to the Third Edition Updated references and improved examples throughout. New sections on random parameters linear regression and ordered probability models including the hierarchical ordered probit model. A new section on random parameters models with heterogeneity in the means and variances of parameter estimates. Multiple new sections on correlated random parameters and correlated grouped random parameters in probit, logit and hazard-based models. A new section discussing the practical aspects of random parameters model estimation. A new chapter on Latent Class Models. A new chapter on Bivariate and Multivariate Dependent Variable Models. Statistical and Econometric Methods for Transportation Data Analysis, Third Edition can serve as a textbook for advanced undergraduate, Masters, and Ph.D. students in transportation-related disciplines including engineering, economics, urban and regional planning, and sociology. The book also serves as a technical reference for researchers and practitioners wishing to examine and understand a broad range of statistical and econometric tools required to study transportation problems.

Requiring only introductory statistics and basic mathematics, this textbook avoids jargon and provides worked examples, data sets and R code, and review exercises. Designed for advanced undergraduates and postgraduates studying biostatistics and experiment design in biology-related fields, it applies statistical concepts to biological scenarios.

Available in English for the first time, this classic and influential book by the late Kohei Ohtsu presents real examples of ships in motion under irregular ocean waves, how to understand the characteristics of fluctuations of stochastic phenomena through spectral analysis methods and statistical modeling. It also explains how to realize prediction and optimal control based on time series models. In recent years, the need to improve safety and reduce environmental impact in ship operations has been increasing, and the statistical methods presented in this book will be increasingly needed in the future. In addition, the recent development of innovative AI technology and highspeed communications will make it possible to adapt this method not only to ship monitoring and control, but also to any field that involves irregular fluctuations, and it is expected to contribute to solving issues that have been difficult to solve in the past. Part 1 describes classical spectral method for the analysis of stochastic phenomena. In Part 2, this book explains methods to construct time series models using the information criterion, to capture the characteristics of ship and engine motions using the model, to design a model-based monitoring system that informs navigators operating the ship and managers ashore. Furthermore, it explains statistical control method to design an autopilot system and the governor of a marine engine, while showing actual examples. Part 3 presents the basic knowledge necessary for understanding these topics of the book, namely, the basic theory of ship motion, probability and statistics, Kalman filter and statistical optimal control theory.

This book collects important advances in methodology and data analysis for directional statistics. It is the companion book of the more theoretical treatment presented in Modern Directional Statistics (CRC Press, 2017). The field of directional statistics has received a lot of attention due to demands from disciplines such as life sciences or machine learning, the availability of massive data sets requiring adapted statistical techniques, and technological advances. This book covers important progress in bioinformatics, biology, astrophysics, oceanography, environmental sciences, earth sciences, machine learning and social sciences.