The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.

Succeeding in Life and Career is an advanced comprehensive text designed to help teens adjust to change, achieve career readiness, and fulfill their potential. The 21st century challenges pose unique demands on young people learning to manage their lives and prepare for successful futures, and the text addresses these challenges. It encourages students to hone critical-thinking, problem-solving, and decision-making skills and apply them to situations in the real world. Succeeding in Life and Career also helps teens acquire relationship, resource management, and healthy living skills. Unit One is devoted solely to career preparation, employability skills, teamwork, leadership, and entrepreneurship. Eight Career Discovery two-page spreads explore the 16 career clusters. They identify popular career choices as well as the education, training, skills, and personal qualities needed for success in those fields. The nutrition information reflects USDA's MyPlate food guidance system, and the information on lifespan development covers all age categories. Engaging features appear throughout to help students develop life and work skills, healthy lifestyle and wellness choices, a commitment to community service, financial literacy, and knowledge of sustainable living. Chapter activities encourage students to explore text concepts further through cocurricular and technology challenges, FCCLA participation, portfolio development, and journal writing. Hundreds of special features, experiments, color photographs, illustrations, tables, and charts expand key concepts and make learning interesting and fun.