This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.

Describes the current status and potential of synthetic chemistry designed to use and to generate fewer hazardous substances. Examines new techniques for carrying out transformations in environmentally benign solvent systems. Presents research results on the replacement of hazardous feedstocks with biologically derived, innocuous feedstocks; of hazardous reagents with visible light; and of phosgene, benzene, and halogens in a variety of industrially important reactions. Provides examples of how alternative synthetic design for pollution prevention has been made commercially viable. Describes how to conduct a source-reduction assessment and analyzes computer-assisted synthetic design.

This handbook is the first to cover all aspects of stability testing in pharmaceutical development. Written by a group of international experts, the book presents a scientific understanding of regulations and balances methodologies and best practices.

"Completely revised and expanded throughout. Presents a comprehensive integrated, sequenced approach to drug dosage formulation, design, and evaluation. Indentifies the pharmacodynamic and physicochemical factors influencing drug action through various routes of administration."

How do we know if we're following our true callings? How do we sharpen our senses to cut through the distractions of everyday reality and hear the calls that are beckoning us? is the first book to examine the many kinds of calls we receive and the great variety of channels through which they come to us. A calling may be to do something (change careers, go back to school, have a child) or to be something (more creative, less judgmental, more loving). While honoring a calling's essential mystery, this book also guides readers to ask and answer the fundamental questions that arise from any calling: How do we recognize it? How do we distinguish the true call from the siren song? How do we handle our resistance to a call? What happens when we say yes? What happens when we say no? Drawing on the hard-won wisdom and powerful stories of people who have followed their own calls, Gregg Levoy shows us the many ways to translate a calling into action. In a style that is poetic, exuberant, and keenly insightful, he presents an illuminating and ultimately practical inquiry into how we listen and respond to our calls, whether at work or at home, in our relationships or in service. Callings is a compassionate guide to discovering your own callings and negotiating the tight passages to personal power and authenticity.

This volume consists of papers based on presentations given at a roundtable on “New Directions for Historical Linguistics: Impact and Synthesis, 50 Years Later,” held at the 23rd International Conference on Historical Linguistics in 2017, as well as an introduction by the editors.

Delivering an encompassing overview of the factors, varieties, and applications determining product containment, this concise reference provides authoritative information on containment processes. It reviews the historical context, definition, evolution, and application of containment technology, analyzes a variety of containment techniques in new