Teaches Students How to Perform Spatio-Temporal Analyses within Epidemiological StudiesSpatio-Temporal Methods in Environmental Epidemiology is the first book of its kind to specifically address the interface between environmental epidemiology and spatio-temporal modeling. In response to the growing need for collaboration between statisticians and

Spatio-Temporal Methods in Environmental Epidemiology with R, like its First Edition, explores the interface between environmental epidemiology and spatio-temporal modeling. It links recent developments in spatio-temporal theory with epidemiological applications. Drawing on real-life problems, it shows how recent advances in methodology can assess the health risks associated with environmental hazards. The book's clear guidelines enable the implementation of the methodology and estimation of risks in practice. New additions to the Second Edition include: a thorough exploration of the underlying concepts behind knowledge discovery through data; a new chapter on extracting information from data using R and the tidyverse; additional material on methods for Bayesian computation, including the use of NIMBLE and Stan; new methods for performing spatio-temporal analysis and an updated chapter containing further topics. Throughout the book there are new examples, and the presentation of R code for examples has been extended. Along with these additions, the book now has a GitHub site (https://spacetime-environ.github.io/stepi2) that contains data, code and further worked examples. Features: • Explores the interface between environmental epidemiology and spatio­-temporal modeling • Incorporates examples that show how spatio-temporal methodology can inform societal concerns about the effects of environmental hazards on health • Uses a Bayesian foundation on which to build an integrated approach to spatio-temporal modeling and environmental epidemiology • Discusses data analysis and topics such as data visualization, mapping, wrangling and analysis • Shows how to design networks for monitoring hazardous environmental processes and the ill effects of preferential sampling • Through the listing and application of code, shows the power of R, tidyverse, NIMBLE and Stan and other modern tools in performing complex data analysis and modeling Representing a continuing important direction in environmental epidemiology, this book – in full color throughout – underscores the increasing need to consider dependencies in both space and time when modeling epidemiological data. Readers will learn how to identify and model patterns in spatio-temporal data and how to exploit dependencies over space and time to reduce bias and inefficiency when estimating risks to health.

The world is becoming increasingly complex, with larger quantities of data available to be analyzed. It so happens that much of these "big data" that are available are spatio-temporal in nature, meaning that they can be indexed by their spatial locations and time stamps. Spatio-Temporal Statistics with R provides an accessible introduction to statistical analysis of spatio-temporal data, with hands-on applications of the statistical methods using R Labs found at the end of each chapter. The book: Gives a step-by-step approach to analyzing spatio-temporal data, starting with visualization, then statistical modelling, with an emphasis on hierarchical statistical models and basis function expansions, and finishing with model evaluation Provides a gradual entry to the methodological aspects of spatio-temporal statistics Provides broad coverage of using R as well as "R Tips" throughout. Features detailed examples and applications in end-of-chapter Labs Features "Technical Notes" throughout to provide additional technical detail where relevant Supplemented by a website featuring the associated R package, data, reviews, errata, a discussion forum, and more The book fills a void in the literature and available software, providing a bridge for students and researchers alike who wish to learn the basics of spatio-temporal statistics. It is written in an informal style and functions as a down-to-earth introduction to the subject. Any reader familiar with calculus-based probability and statistics, and who is comfortable with basic matrix-algebra representations of statistical models, would find this book easy to follow. The goal is to give as many people as possible the tools and confidence to analyze spatio-temporal data.

Progressively more and more attention has been paid to how location affects health outcomes. The area of disease mapping focusses on these problems, and the Bayesian paradigm has a major role to play in the understanding of the complex interplay of context and individual predisposition in such studies of disease. Using R for Bayesian Spatial and Spatio-Temporal Health Modeling provides a major resource for those interested in applying Bayesian methodology in small area health data studies. Features: Review of R graphics relevant to spatial health data Overview of Bayesian methods and Bayesian hierarchical modeling as applied to spatial data Bayesian Computation and goodness-of-fit Review of basic Bayesian disease mapping models Spatio-temporal modeling with MCMC and INLA Special topics include multivariate models, survival analysis, missing data, measurement error, variable selection, individual event modeling, and infectious disease modeling Software for fitting models based on BRugs, Nimble, CARBayes and INLA Provides code relevant to fitting all examples throughout the book at a supplementary website The book fills a void in the literature and available software, providing a crucial link for students and professionals alike to engage in the analysis of spatial and spatio-temporal health data from a Bayesian perspective using R. The book emphasizes the use of MCMC via Nimble, BRugs, and CARBAyes, but also includes INLA for comparative purposes. In addition, a wide range of packages useful in the analysis of geo-referenced spatial data are employed and code is provided. It will likely become a key reference for researchers and students from biostatistics, epidemiology, public health, and environmental science.

This handbook focuses on the enormous literature applying statistical methodology and modelling to environmental and ecological processes. The 21st century statistics community has become increasingly interdisciplinary, bringing a large collection of modern tools to all areas of application in environmental processes. In addition, the environmental community has substantially increased its scope of data collection including observational data, satellite-derived data, and computer model output. The resultant impact in this latter community has been substantial; no longer are simple regression and analysis of variance methods adequate. The contribution of this handbook is to assemble a state-of-the-art view of this interface. Features: An internationally regarded editorial team. A distinguished collection of contributors. A thoroughly contemporary treatment of a substantial interdisciplinary interface. Written to engage both statisticians as well as quantitative environmental researchers. 34 chapters covering methodology, ecological processes, environmental exposure, and statistical methods in climate science.

Presents an overview of the complex biological systems used within a global public health setting and features a focus on malaria analysis Bridging the gap between agent-based modeling and simulation (ABMS) and geographic information systems (GIS), Spatial Agent-Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology provides a useful introduction to the development of agent-based models (ABMs) by following a conceptual and biological core model of Anopheles gambiae for malaria epidemiology. Using spatial ABMs, the book includes mosquito (vector) control interventions and GIS as two example applications of ABMs, as well as a brief description of epidemiology modeling. In addition, the authors discuss how to most effectively integrate spatial ABMs with a GIS. The book concludes with a combination of knowledge from entomological, epidemiological, simulation-based, and geo-spatial domains in order to identify and analyze relationships between various transmission variables of the disease. Spatial Agent-Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology also features: Location-specific mosquito abundance maps that play an important role in malaria control activities by guiding future resource allocation for malaria control and identifying hotspots for further investigation Discussions on the best modeling practices in an effort to achieve improved efficacy, cost-effectiveness, ecological soundness, and sustainability of vector control for malaria An overview of the various ABMs, GIS, and spatial statistical methods used in entomological and epidemiological studies, as well as the model malaria study A companion website with computer source code and flowcharts of the spatial ABM and a landscape generator tool that can simulate landscapes with varying spatial heterogeneity of different types of resources including aquatic habitats and houses Spatial Agent-Based Simulation Modeling in Public Health: Design, Implementation, and Applications for Malaria Epidemiology is an excellent reference for professionals such as modeling and simulation experts, GIS experts, spatial analysts, mathematicians, statisticians, epidemiologists, health policy makers, as well as researchers and scientists who use, manage, or analyze infectious disease data and/or infectious disease-related projects. The book is also ideal for graduate-level courses in modeling and simulation, bioinformatics, biostatistics, public health and policy, and epidemiology.

This book provides a practical, comprehensive and up-to-date overview of the use of spatial statistics in epidemiology - the study of the incidence and distribution of diseases. Used appropriately, spatial analytical methods in conjunction with GIS and remotely sensed data can provide significant insights into the biological patterns and processes that underlie disease transmission. In turn, these can be used to understand and predict disease prevalence. This user-friendly text brings together the specialised and widely-dispersed literature on spatial analysis to make these methodological tools accessible to epidemiologists for the first time. With its focus is on application rather than theory, Spatial Analysis in Epidemiology includes a wide range of examples taken from both medical (human) and veterinary (animal) disciplines, and describes both infectious diseases and non-infectious conditions. Furthermore, it provides worked examples of methodologies using a single data set from the same disease example throughout, and is structured to follow the logical sequence of description of spatial data, visualisation, exploration, modelling and decision support. This accessible text is aimed at graduate students and researchers dealing with spatial data in the fields of epidemiology (both medical and veterinary), ecology, zoology and parasitology, environmental science, geography and statistics.

Geospatial health data are essential to inform public health and policy. These data can be used to quantify disease burden, understand geographic and temporal patterns, identify risk factors, and measure inequalities. Geospatial Health Data: Modeling and Visualization with R-INLA and Shiny describes spatial and spatio-temporal statistical methods and visualization techniques to analyze georeferenced health data in R. The book covers the following topics: Manipulate and transform point, areal, and raster data, Bayesian hierarchical models for disease mapping using areal and geostatistical data, Fit and interpret spatial and spatio-temporal models with the Integrated Nested Laplace Approximations (INLA) and the Stochastic Partial Differential Equation (SPDE) approaches, Create interactive and static visualizations such as disease maps and time plots, Reproducible R Markdown reports, interactive dashboards, and Shiny web applications that facilitate the communication of insights to collaborators and policy makers. The book features fully reproducible examples of several disease and environmental applications using real-world data such as malaria in The Gambia, cancer in Scotland and USA, and air pollution in Spain. Examples in the book focus on health applications, but the approaches covered are also applicable to other fields that use georeferenced data including epidemiology, ecology, demography or criminology. The book provides clear descriptions of the R code for data importing, manipulation, modeling and visualization, as well as the interpretation of the results. This ensures contents are fully reproducible and accessible for students, researchers and practitioners.

Handbook of Spatial Epidemiology explains how to model epidemiological problems and improve inference about disease etiology from a geographical perspective. Top epidemiologists, geographers, and statisticians share interdisciplinary viewpoints on analyzing spatial data and space-time variations in disease incidences. These analyses can provide imp