This book constitutes the thoroughly refereed post-conference proceedings of the Third International Workshop on Spatio-temporal Image Analysis for Longitudinal and Time-Series Image Data, STIA 2014, held in conjunction with MICCAI 2014 in Boston, MA, USA, in September 2014. The 7 papers presented in this volume were carefully reviewed and selected from 15 submissions. They are organized in topical sections named: longitudinal registration and shape modeling, longitudinal modeling, reconstruction from longitudinal data, and 4D image processing.

This book constitutes the refereed proceedings of the Second International Workshop on Spatio-temporal Image Analysis for Longitudinal and Time-Series Image Data, STIA 2012, held in conjunction with MICCAI 2012 in Nice, France, in October 2012. The 13 papers presented in this volume were carefully reviewed and selected from 22 submissions. They are organized in topical sections named: longitudinal registration and transport; spatio-temporal analysis for shapes; spatio-temporal analysis under appearance changes; and spatio-temporal analysis for biology.

Image sequence processing is becoming a tremendous tool to analyze spatio-temporal data in all areas of natural science. It is the key to studythe dynamics of of complex scientific phenomena. Methods from computer science and the field of application are merged establishing new interdisciplinary research areas. This monograph emerged from scientific applications and thus is an example for such an interdisciplinaryapproach. It is addressed both to computer scientists and to researchers from other fields who are applying methods of computer vision. The results presented are mostly from environmental physics (oceanography) but they will be illuminating and helpful for researchers applying similar methods in other areas.

Change Detection and Image Time Series Analysis 2 presents supervised machine-learning-based methods for temporal evolution analysis by using image time series associated with Earth observation data. Chapter 1 addresses the fusion of multisensor, multiresolution and multitemporal data. It proposes two supervised solutions that are based on a Markov random field: the first relies on a quad-tree and the second is specifically designed to deal with multimission, multifrequency and multiresolution time series. Chapter 2 provides an overview of pixel based methods for time series classification, from the earliest shallow learning methods to the most recent deep-learning-based approaches. Chapter 3 focuses on very high spatial resolution data time series and on the use of semantic information for modeling spatio-temporal evolution patterns. Chapter 4 centers on the challenges of dense time series analysis, including pre processing aspects and a taxonomy of existing methodologies. Finally, since the evaluation of a learning system can be subject to multiple considerations, Chapters 5 and 6 offer extensive evaluations of the methodologies and learning frameworks used to produce change maps, in the context of multiclass and/or multilabel change classification issues.

The three-volume set LNCS 8673, 8674, and 8675 constitutes the refereed proceedings of the 17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014, held in Boston, MA, USA, in September 2014. Based on rigorous peer reviews, the program committee carefully selected 253 revised papers from 862 submissions for presentation in three volumes. The 100 papers included in the second volume have been organized in the following topical sections: biophysical modeling and simulation; atlas-based transfer of boundary conditions for biomechanical simulation; temporal and motion modeling; computer-aided diagnosis; pediatric imaging; endoscopy; ultrasound imaging; machine learning; cardiovascular imaging; intervention planning and guidance; and brain.

Change Detection and Image Time Series Analysis 1 presents a wide range of unsupervised methods for temporal evolution analysis through the use of image time series associated with optical and/or synthetic aperture radar acquisition modalities. Chapter 1 introduces two unsupervised approaches to multiple-change detection in bi-temporal multivariate images, with Chapters 2 and 3 addressing change detection in image time series in the context of the statistical analysis of covariance matrices. Chapter 4 focuses on wavelets and convolutional-neural filters for feature extraction and entropy-based anomaly detection, and Chapter 5 deals with a number of metrics such as cross correlation ratios and the Hausdorff distance for variational analysis of the state of snow. Chapter 6 presents a fractional dynamic stochastic field model for spatio temporal forecasting and for monitoring fast-moving meteorological events such as cyclones. Chapter 7 proposes an analysis based on characteristic points for texture modeling, in the context of graph theory, and Chapter 8 focuses on detecting new land cover types by classification-based change detection or feature/pixel based change detection. Chapter 9 focuses on the modeling of classes in the difference image and derives a multiclass model for this difference image in the context of change vector analysis.

Brain Mapping: A Comprehensive Reference, Three Volume Set offers foundational information for students and researchers across neuroscience. With over 300 articles and a media rich environment, this resource provides exhaustive coverage of the methods and systems involved in brain mapping, fully links the data to disease (presenting side by side maps of healthy and diseased brains for direct comparisons), and offers data sets and fully annotated color images. Each entry is built on a layered approach of the content – basic information for those new to the area and more detailed material for experienced readers. Edited and authored by the leading experts in the field, this work offers the most reputable, easily searchable content with cross referencing across articles, a one-stop reference for students, researchers and teaching faculty. Broad overview of neuroimaging concepts with applications across the neurosciences and biomedical research Fully annotated color images and videos for best comprehension of concepts Layered content for readers of different levels of expertise Easily searchable entries for quick access of reputable information Live reference links to ScienceDirect, Scopus and PubMed

Several recent papers underline methodological points that limit the validity of published results in imaging studies in the life sciences and especially the neurosciences (Carp, 2012; Ingre, 2012; Button et al., 2013; Ioannidis, 2014). At least three main points are identified that lead to biased conclusions in research findings: endemic low statistical power and, selective outcome and selective analysis reporting. Because of this, and in view of the lack of replication studies, false discoveries or solutions persist. To overcome the poor reliability of research findings, several actions should be promoted including conducting large cohort studies, data sharing and data reanalysis. The construction of large-scale online databases should be facilitated, as they may contribute to the definition of a “collective mind” (Fox et al., 2014) facilitating open collaborative work or “crowd science” (Franzoni and Sauermann, 2014). Although technology alone cannot change scientists’ practices (Wicherts et al., 2011; Wallis et al., 2013, Poldrack and Gorgolewski 2014; Roche et al. 2014), technical solutions should be identified which support a more “open science” approach. Also, the analysis of the data plays an important role. For the analysis of large datasets, image processing pipelines should be constructed based on the best algorithms available and their performance should be objectively compared to diffuse the more relevant solutions. Also, provenance of processed data should be ensured (MacKenzie-Graham et al., 2008). In population imaging this would mean providing effective tools for data sharing and analysis without increasing the burden on researchers. This subject is the main objective of this research topic (RT), cross-listed between the specialty section “Computer Image Analysis” of Frontiers in ICT and Frontiers in Neuroinformatics. Firstly, it gathers works on innovative solutions for the management of large imaging datasets possibly distributed in various centers. The paper of Danso et al. describes their experience with the integration of neuroimaging data coming from several stroke imaging research projects. They detail how the initial NeuroGrid core metadata schema was gradually extended for capturing all information required for future metaanalysis while ensuring semantic interoperability for future integration with other biomedical ontologies. With a similar preoccupation of interoperability, Shanoir relies on the OntoNeuroLog ontology (Temal et al., 2008; Gibaud et al., 2011; Batrancourt et al., 2015), a semantic model that formally described entities and relations in medical imaging, neuropsychological and behavioral assessment domains. The mechanism of “Study Card” allows to seamlessly populate metadata aligned with the ontology, avoiding fastidious manual entrance and the automatic control of the conformity of imported data with a predefined study protocol. The ambitious objective with the BIOMIST platform is to provide an environment managing the entire cycle of neuroimaging data from acquisition to analysis ensuring full provenance information of any derived data. Interestingly, it is conceived based on the product lifecycle management approach used in industry for managing products (here neuroimaging data) from inception to manufacturing. Shanoir and BIOMIST share in part the same OntoNeuroLog ontology facilitating their interoperability. ArchiMed is a data management system locally integrated for 5 years in a clinical environment. Not restricted to Neuroimaging, ArchiMed deals with multi-modal and multi-organs imaging data with specific considerations for data long-term conservation and confidentiality in accordance with the French legislation. Shanoir and ArchiMed are integrated into FLI-IAM1, the national French IT infrastructure for in vivo imaging.