“Zeti Hunt,” part two! Now that Zavok has his pack, it’s time for them to make a big move. But Jewel the Beetle, newly appointed Restoration leader, has called on Sonic, Tails, and the Chaotix to run interference. Will they be able to stop the Zeti and make it home in time for spaghetti!?

"In Every Kingdom There Must Exist A Little Chaos!": Be careful who you trust, Sonic! As time runs out for the ailing King Acorn, the Freedom Fighters desperately search for a cure to the crystalization process that is slowly devouring the king's body! Hoping that a chaos emerald can reverse the deadly effects, the gang must turn to the only one they know with a chaos emerald on hand -- KNUCKLES THE ECHIDNA! But will the guardian of the floating island feel so generous? Yeah, right!

"Unsung Heroes," Part Two. When Sonic is away, the Secret Freedom Fighters make evil pay! Deep under the city, in the scar left by the Battle Bird Armada, the evil wizard Ixis Naugus is shaping the earth to his whim. Elias, the deposed king, must lead his squad of Secret Freedom Fighters to find out what's going on! But with Naugus able to control the stones and shadows, will Elias' team emerge alive?

Development of the Nervous System presents a broad and basic treatment of the established and evolving principles of neural development as exemplified by key experiments and observations from past and recent times. The text is organized ontogenically. It begins with the emergence of the neural primordium and takes a chapter-by-chapter approach in succeeding events in neural development: patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, neuron survival and death, synapse formation and developmental plasticity. Finally, in the last chapter, with the construction phase nearing completion, we examine the emergence of behavior. This new edition reflects the complete modernization of the field that has been achieved through the intensive application of molecular, genetic, and cell biological approaches. It is richly illustrated with color photographs and original drawings. Combined with the clear and concise writing, the illustrations make this a book that is well suited to students approaching this intriguing field for the first time. - Thorough survey of the field of neural development - Concise but complete, suitable for a one semester course on upper level undergraduate or graduate level - Focus on fundamental principles of organogenesis in the nervous system - Integrates information from a variety of model systems, relating them to human nervous system development, including disorders of development - Systematically develops knowledge from the description of key experiments and results - Organized ontologically - Carefully edited to be presented in one voice - New edition thoroughly updated and revised to include major new findings - All figures in full color, updated and revised - Specific attention on revising the chapter on cognitive and behavioral development to provide a foundation and outlook towards those very fast moving areas - Instructor website with figure bank and test questions

Evolutionary Neuroscience is a collection of articles in brain evolution selected from the recent comprehensive reference, Evolution of Nervous Systems (Elsevier, Academic Press, 2007). The selected chapters cover a broad range of topics from historical theory to the most recent deductions from comparative studies of brains. The articles are organized in sections focused on theories and brain scaling, the evolution of brains from early vertebrates to present-day fishes, amphibians, reptiles and birds, the evolution of mammalian brains, and the evolution of primate brains, including human brains. Each chapter is written by a leader or leaders in the field, and has been reviewed by other experts. Specific topics include brain character reconstruction, principles of brain scaling, basic features of vertebrate brains, the evolution of the major sensory systems, and other parts of brains, what we can learn from fossils, the origin of neocortex, and the evolution of specializations of human brains. The collection of articles will be interesting to anyone who is curious about how brains evolved from the simpler nervous systems of the first vertebrates into the many different complex forms now found in present-day vertebrates. This book would be of use to students at the graduate or undergraduate levels, as well as professional neuroscientists, cognitive scientists, and psychologists. Together, the chapters provide a comprehensive list of further reading and references for those who want to inquire further. - The most comprehensive, authoritative and up-to-date single volume collection on brain evolution - Full color throughout, with many illustrations - Written by leading scholars and experts

Now in its 10th edition, Sleisenger and Fordtran?s Gastrointestinal and Liver Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of gastroenterology and hepatology. Overcome your most complex clinical challenges and make optimal use of the newest techniques, technologies, and treatments?with superb guidance from hundreds of world-renowned authorities. Meticulous updates throughout include the latest approaches and improvements in gastrointestinal and liver disease diagnosis and therapy as well as hundreds of images and 35 new procedural videos. "..one of the most valuable clinical resources in the dynamic field of gastroenterology and hepatology." Reviewed by Brindusa Diaconu on behalf of the Journal of Gastrointestinal and Liver Diseases, July 2015 "..an engaging, educational yet clinically orientated textbook which is relevant to modern clinical practice." Reviewed by Dr Harry Brown on behalf of glycosmedia.com, April 2015 "I can personally attest to the remarkable advances that have been made, as I was author of the chapter on eosinophilic gastroenteritis in the second edition of the textbook, and reading the same chapter in the tenth edition underscores the important advances that have been made in our understanding of the molecular basis as well as the pathophysiology of this and related disorders." Foreword by Norton J. Greenberger, MD Boston, Massachusetts, June 2015 Consult this title on your favorite e-reader. Get the essential gastroenterology information you need from one authoritative source with an outstanding global reputation for excellence. Zero in on the key information you need to know with a consistent, full-color chapter design. Stay up to date with emerging and challenging topics: enteric microbiota and probiotics; fecal microbiota transplantation; Clostridium difficile colitis; and factitious gastrointestinal diseases. Incorporate the latest findings and improvements in care for liver disease patients—from diagnosis and treatment through post-treatment strategies and management of complications. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.

Focusing on the problems that brains help organisms solve, Neurobiology: A Functional Approach asks not only how the nervous system works but also why it works as it does. This text introduces readers to neurobiology through an evolutionary, organismal, and experimental perspective. With a strong emphasis on neural circuits and systems, it bridges the gap between the cellular and molecular end and the cognitive end of the neuroscience spectrum, allowing students to grasp the full breadth of the subject. Neurobiology covers not only what neuroscientists have learned about the brain in terms of facts and ideas, but also how they have learned it through key experiments.

In the rapidly-evolving landscape of neurosciences, it is no easy task to select a limited array of topics to present in a text such as this. The current volume takes as its purpose to provide a representative survey of the current science of brain repair for those seeking to establish a foundation in the field or to replenish a prior knowledge base that may have lapsed in its currency. It also hopes to offer insights into what remains elusive to our collective investigations, defining the “frontiers” of brain repair for those that are currently immersed in the exciting intersection of biological advances and neuroscientific discoveries. In Chapter 1 the fundamentals of imaging transplanted cells is discussed with emphasis on animal models as well as the horizon for clinical trials. Then, detailed methods on the culture of neural stem cells is reviewed as a foundation for approaching therapeutic goals. Chapter 3 presents the broad scope of animal models that serve as the foundation for developmental and pre-clinical investigation, with mention of recent genetically engineered mouse models that represent the best models for studying disease development and treatment. Chapter 4 provides background on the delivery techniques to animals and patients that are available, providing vital information on the subtleties of technique necessary for optimal cellular grafting. Chapters 5 and 6 discuss new and evolving information on the origins of brain tumors and the indelible role of stromal and microenvironmental influences on oncogenesis and tumor progression. Subsequently, the utility of neural stem cells as cellular vehicles to deliver chemotherapeutics to broad neuropathology is reviewed. In Chapter 8 the scope of treating brain tumors is expanded beyond stem cells, to present the best biological interventions to improve upon current treatment options for brain malignancy. The last two chapters present a comprehensive review on stem cell and gene therapy options for treating cerebrovascular and neurovascular pathology. In amassing this collection, my intention has been to provide the reader with a broad introduction into molecular imaging, stem cell biology, cell therapy, animal models, central nervous system malignancies, stroke, and neurodegeneration. My hope is that Frontiers of Brain Repair will be the intellectual soil from which a deeply rooted and well-nourished vintage of neuroscience will arise.

The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation plays in adaptive evolution, developmental biology and susceptibility to disease. The book sheds light on gene regulation across evolutionary timelines, illuminating new areas of focus and future research. Chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time, and in response to environmental and local conditions, epigenetics in adaptive evolution, and adaptive gene regulation in healthy processes and developmental biology, and in disease biology. Throughout the book, a comparative approach is adopted across organisms to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology. - Reviews key elements in the regulation of gene expression and modes of studying gene regulation across evolutionary timelines - Adopts a cross-species view, synthesizing recent sequencing and GWAS studies across organisms to draw out fresh meaning and highlight pathways for future research - Considers altered gene expression associated with developmental defects and disease, as well as healthy biology and physiology, and our adaptive response to disease influence

Already known as the reference of choice for expert coverage on the structure and function of the human brain and the nervous system, Nolte’s The Human Brain continues to impress with essential updates throughout this new edition. It includes a new chapter on formation, modification, and repair of connections, with coverage of learning and memory, as well as the coming revolution of ways to fix damaged nervous systems, trophic factors, stem cells, and more. 550 full-color illustrations—more than 650 in all—support the text and depict every nuance of brain function. But, best of all, your purchase now includes access to Student Consult, including all of the book’s illustrations, video clips, and additional software, plus many other exclusive features at www.studentconsult.com. Features a single-authored approach for a more consistent, readable text. Discusses all key topics in functional neuroanatomy and neuroscience, giving you well-rounded coverage of this complex subject. Includes clinical examples throughout for a real-life perspective. Uses summary statement headings that speed you to the information you need. Presents chapter outlines that encourage you to stay organized and focused. Incorporates 3-dimensional brain images and more than 650 illustrations that add increased visual clarity and a greater understanding of every concept. Includes a glossary of key terms that elucidates every part of the text. Features updates throughout, as well as many new illustrations using the most current neuroimaging techniques, reflecting recent developments and changes in understanding to acquaint you with the very latest knowledge in the field. Discusses the hot topic of neural plasticity in a new chapter on formation, modification, and repair of connections, with coverage of learning and memory, as well as the coming revolution in ways to fix damaged nervous systems, trophic factors, stem cells, and more. Uses chapter outlines, offering you a focused approach to study. Offers unlimited access to the Student Consult, withvideo clips and additional software at www.studentconsult.com, so you can consult it anywhere you go...perform quick searches...add your own notes and bookmarks...follow Integration Links to related bonus content from other Student Consult titles...and reference all of the other Student Consult titles you own online, too—all in one place!