Solvent Extraction in Biotechnology deals with the reco- very and purification of primary and secondary metabolites by solvent extraction. In the first part the reaction engineering principles: definitions, thermodynamic fundamentals, and system models, the kinetics of mass transfer between two phases without and with chemical reaction as well as extraction equipment, which are important for downstream processing in biotechnology, are considered in detail. The special part of the book describes the recovery of low-molecular metabolites: alcohols, acids and antibiotics with organic solvents, carrier-modifier-solvent systems, supercritical gases as well as with liquid membrane techniques. Several practical examples are given for the recovery of different metabolites as well as for the calculation of the extraction processes necessary for equipment design. Besides solvent extraction, novel separation techniques with liquid membrane, microemulsion and reversed micelles are also presented. This book will introduce the biochemical engineer and process engineer to the recovery of products from complex cultivation broths by modern techniques of solvent extraction and help them with process design.

The main challenge in modern solvent extraction separation is that most techniques are mainly empirical, specific and particular for narrow fields of practice and require a large degree of experimentation. This concise and modern book provides a complete overview of both solvent extraction separation techniques and the novel and unified competitive complexation/solvation theory. This novel and unified technique presented in the book provides a key for a preliminary quantitative prediction of suitable extraction systems without experimentation, thus saving researchers time and resources. - Analyzes and compares both classical and new competitive models and techniques - Offers a novel and unified competitive complexation / solvation theory that permits researchers to standardize some parameters, which decreases the need for experimentation at R&D - Presents examples of applications in multiple disciplines such as chemical, biochemical, radiochemical, pharmaceutical and analytical separation - Written by an outstanding scientist who is prolific in the field of separation science

Conference proceedings from ISEC 93. Published on behalf of the Society for Chemistry in Industry.

Subcritical water is a green extraction solvent compared to conventional extraction solvents. While experimental results on subcritical water extraction (SWE) technology have been published piecemeal, there has been no comprehensive review of the state of the art. Green Extraction in Separation Technology fills that gap, serving to cover extracting with subcritical water as an environmentally friendly solvent. FEATURES Presents new technologies for extracting natural compounds from plants and compares the advantages and disadvantages versus SWE Explains research on SWE over the last 15 years Offers an overview of the solubility of different compounds in SWE and related theoretical content Discusses modeling of SWE and describes the development of a new model for this process This monograph is aimed at researchers and advanced students in chemical and biochemical engineering.

A complete and up-to-date presentation of the fundamental theoretical principles and many applications of solvent extraction, this enhanced Solvent Extraction Principles and Practice, Second Edition includes new coverage of the recent developments in solvent extraction processes, the use of solvent extraction in analytical applications and waste re

This book describes separation and purification techniquesùadsorption, ion exchange and liquid chromatography on solid supportsùused for fermentation and biochemical feedstreams. Emphasis is placed on basic sorption theory, laboratory evaluation techniques, sorptive materials and their characteristics, scale-up of laboratory techniques, and their industrial applications. Each chapter contains specific examples illustrating the use of purification techniques in biotechnology processes.

The term “natural products” spans an extremely large and diverse range of chemical compounds derived and isolated from biological sources. Our interest in natural products can be traced back thousands of years for their usefulness to humankind, and this continues to the present day. Compounds and extracts derived from the biosphere have found uses in medicine, agriculture, cosmetics, and food in ancient and modern societies around the world. Therefore, the ability to access natural products, understand their usefulness, and derive applications has been a major driving force in the field of natural product research. The first edition of Natural Products Isolation provided readers for the first time with some practical guidance in the process of extraction and isolation of natural products and was the result of Richard Cannell’s unique vision and tireless efforts. Unfortunately, Richard Cannell died in 1999 soon after completing the first edition. We are indebted to him and hope this new edition pays adequate tribute to his excellent work. The first edition laid down the “ground rules” and established the techniques available at the time. Since its publication in 1998, there have been significant developments in some areas in natural product isolation. To capture these developments, publication of a second edition is long overdue, and we believe it brings the work up to date while still covering many basic techniques known to save time and effort, and capable of results equivalent to those from more recent and expensive techniques.

The current book gives an excellent insight into downstream processing technology and explains how to establish a successful strategy for an efficient recovery, isolation and purification of biosynthetic products. In addition to the overview of purification steps and unit operations, the authors provide practical information on capital and operating costs related to downstream processing.

This book presents a complete picture of the current state-of-the-art in alternative and green solvents used for laboratory and industrial natural product extraction in terms of the latest innovations, original methods and safe products. It provides the necessary theoretical background and details on extraction, techniques, mechanisms, protocols, industrial applications, safety precautions and environmental impacts. This book is aimed at professionals from industry, academicians engaged in extraction engineering or natural product chemistry research, and graduate level students. The individual chapters complement one another, were written by respected international researchers and recognized professionals from the industry, and address the latest efforts in the field. It is also the first sourcebook to focus on the rapid developments in this field.