This book reviews current design paths for soft sensors, and guides readers in evaluating different choices. The book presents case studies resulting from collaborations between the authors and industrial partners. The solutions presented, some of which are implemented on-line in industrial plants, are designed to cope with a wide range of applications from measuring system backup and what-if analysis through real-time prediction for plant control to sensor diagnosis and validation.

This book reviews current design paths for soft sensors, and guides readers in evaluating different choices. The book presents case studies resulting from collaborations between the authors and industrial partners. The solutions presented, some of which are implemented on-line in industrial plants, are designed to cope with a wide range of applications from measuring system backup and what-if analysis through real-time prediction for plant control to sensor diagnosis and validation.

Advanced Control and Supervision of Mineral Processing Plants describes the use of dynamic models of mineral processing equipment in the design of control, data reconciliation and soft-sensing schemes; through examples, it illustrates tools integrating simulation and control system design for comminuting circuits and flotation columns. Coverage is given to the design of soft sensors based on either single-point measurements or more complex measurements like images. Issues concerning data reconciliation and its employment in the creation of instrument architecture and fault diagnosis are surveyed. In consideration of the widespread use of distributed control and information management systems in mineral processing, the book describes the platforms and toolkits available for implementing such systems. Applications of the techniques described in real plants are used to highlight their benefits; information for all of the examples, together with supporting MATLAB® code can be found at www.springer.com/978-1-84996-105-9.

Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.

Early and accurate fault detection and diagnosis for modern chemical plants can minimize downtime, increase the safety of plant operations, and reduce manufacturing costs. This book presents the theoretical background and practical techniques for data-driven process monitoring. It demonstrates the application of all the data-driven process monitoring techniques to the Tennessee Eastman plant simulator, and looks at the strengths and weaknesses of each approach in detail. A plant simulator and problems allow readers to apply process monitoring techniques.

In the manufacture of bio-therapeutics the importance of a well-known process is key for a high product titer and low batch to batch variations. Soft sensors are based on the concept that online sensor signals can be used as inputs to mathematical models to derive new valuable process information. This information could then be used for better monitoring and control of the bioprocess. The aim of the present thesis has been to develop soft sensor solutions for upstream bioprocessing and demonstrate their usefulness in improving robustness and increase the batch-to-batch reproducibility in bioprocesses. The thesis reviews the potential and possibilities with soft sensors for use in production of bio-therapeutics to realize FDA´s process analytical technology (PAT) initiative. Modelling and hardware sensor alternatives which could be used in a soft sensor setup are described and critically analyzed. Different soft sensor approaches to control glucose feeding in fed-batch cultures of Escherichia coli are described. Measurements of metabolic fluxes and specific carbon dioxide production was used as control parameters to increase product yield and decrease the variability of produced recombinant proteins. Metabolic heat signals were used in uninduced cultures to estimate and control the specific growth rate at a desired level and thereby also estimate the biomass concentration online. The introduction of sequential filtering of the signal enabled this method to be used in a down-scaled system. The risk and high impact of contaminations in cell cultures are also described. An in situ microscope (ISM) was used as an online tool to estimate cell concentration and also to determine cell diameter size which enabled the detection of contaminant cells at an early stage. The work presented in this thesis supports the idea that soft sensors can be a useful tool in the strive towards robust and reliable bioprocesses, to ensure high product quality and increased economic profit.

Over the last few years, interest in the industrial applications of AI and learning systems has surged. This book covers the recent developments and provides a broad perspective of the key challenges that characterize the field of Industry 4.0 with a focus on applications of AI. The target audience for this book includes engineers involved in automation system design, operational planning, and decision support. Computer science practitioners and industrial automation platform developers will also benefit from the timely and accurate information provided in this work. The book is organized into two main sections comprising 12 chapters overall: •Digital Platforms and Learning Systems •Industrial Applications of AI

Condition modelling and control is a technique used to enable decision-making in manufacturing processes of interest to researchers and practising engineering. Condition Monitoring and Control for Intelligent Manufacturing will be bought by researchers and graduate students in manufacturing and control and engineering, as well as practising engineers in industries such as automotive and packaging manufacturing.

Written for industrial and academic researchers and development scientists in the life sciences industry, Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts is a guide to the tools, approaches, and useful developments in bioprocessing. This important guide: • Summarizes state-of-the-art bioprocessing methods and reviews applications in life science industries • Includes illustrative case studies that review six milestone bio-products • Discuses a wide selection of host strain types and disruptive bioprocess technologies

With increasing demands for efficiency and product quality plus progress in the integration of automatic control systems in high-cost mechatronic and safety-critical processes, the field of supervision (or monitoring), fault detection and fault diagnosis plays an important role. The book gives an introduction into advanced methods of fault detection and diagnosis (FDD). After definitions of important terms, it considers the reliability, availability, safety and systems integrity of technical processes. Then fault-detection methods for single signals without models such as limit and trend checking and with harmonic and stochastic models, such as Fourier analysis, correlation and wavelets are treated. This is followed by fault detection with process models using the relationships between signals such as parameter estimation, parity equations, observers and principal component analysis. The treated fault-diagnosis methods include classification methods from Bayes classification to neural networks with decision trees and inference methods from approximate reasoning with fuzzy logic to hybrid fuzzy-neuro systems. Several practical examples for fault detection and diagnosis of DC motor drives, a centrifugal pump, automotive suspension and tire demonstrate applications.