Small Molecules In Oncology
Download Small Molecules In Oncology full books in PDF, epub, and Kindle. Read online free Small Molecules In Oncology ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads.
Author |
: Uwe M. Martens |
Publisher |
: Springer Science & Business |
Total Pages |
: 418 |
Release |
: 2014-04-22 |
ISBN-10 |
: 9783642544903 |
ISBN-13 |
: 3642544908 |
Rating |
: 4/5 (03 Downloads) |
Synopsis Small Molecules in Oncology by : Uwe M. Martens
Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.
Author |
: Uwe M. Martens |
Publisher |
: Springer |
Total Pages |
: 297 |
Release |
: 2018-08-01 |
ISBN-10 |
: 9783319914398 |
ISBN-13 |
: 3319914391 |
Rating |
: 4/5 (98 Downloads) |
Synopsis Small Molecules in Hematology by : Uwe M. Martens
This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title.
Author |
: Zhe-Sheng Chen |
Publisher |
: Frontiers Media SA |
Total Pages |
: 1123 |
Release |
: 2020-07-22 |
ISBN-10 |
: 9782889638840 |
ISBN-13 |
: 2889638847 |
Rating |
: 4/5 (40 Downloads) |
Synopsis Targeted Cancer Therapies, From Small Molecules to Antibodies by : Zhe-Sheng Chen
Author |
: Uwe Martens |
Publisher |
: Springer |
Total Pages |
: |
Release |
: 2018-10-06 |
ISBN-10 |
: 3030129489 |
ISBN-13 |
: 9783030129484 |
Rating |
: 4/5 (89 Downloads) |
Synopsis Small Molecules in Oncology and Hematology by : Uwe Martens
This two-volume set describes the most recent developments in the use of small molecules for targeted therapy in hematology and oncology. In each book a wide range of small molecules are covered. Those of most relevance in hematology include tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib, while, in addition to tyrosine kinase inhibitors, mTOR, MEK, PARP, and multikinase inhibitors and cell cycle and NTRK interacting agents are of particular interest in oncology. For each molecule, chemical structure, mechanism of action, drug targets, and drug interactions are described. The results of preclinical studies and clinical trials are reviewed, with presentation of the latest information on treatment applications. The extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. In presenting key advances in the field, this impressive set will be of interest and value for both researchers and clinicians.
Author |
: John Wing Shing Ho |
Publisher |
: World Scientific |
Total Pages |
: 170 |
Release |
: 2019-04-18 |
ISBN-10 |
: 9789814525640 |
ISBN-13 |
: 9814525642 |
Rating |
: 4/5 (40 Downloads) |
Synopsis Naturally Occurring Small Molecules For Disease And Cancer Treatment: Therapeutic Benefits In Combination Therapy by : John Wing Shing Ho
Western drugs and target medicines for disease treatment come with undesirable side effects that have limited their use in patients for an extended period of time. It is warranted to develop a treatment strategy with alternative medicines to reduce toxicity relating to drugs, in particular, cancer drugs. Thus, a combination therapy with herbal medicines provides a more effective treatment method for hard-to-treat diseases. The recent breakthroughs in naturally occurring small molecules from herbal medicines have provided experimental evidence and are clinically significant in treatment strategies.This unique volume presents the recent developments in the field of herbal medicines for the treatment of diseases and cancer. Recent progress on small molecules isolated from herbal medicines that exhibit therapeutic benefits in humans is highlighted. The book provides an overview of the significant discoveries and pioneering contributions of herbal medicines in combination with other drugs; the author's evaluation of the combination therapy in cancer treatment; and a recent discovery of crocodile tissue extract with pharmacological properties.
Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 226 |
Release |
: 2019-02-26 |
ISBN-10 |
: 9780128176627 |
ISBN-13 |
: 0128176628 |
Rating |
: 4/5 (27 Downloads) |
Synopsis Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy by :
Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy edited by Dr. Nagaraju, PhD., DSc. focuses on overriding the resistance from chemotherapeutic drugs with a broader range of treatment options. It particularly focuses on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways. This volume discusses topics such as pancreatic cancer biology, current therapeutic options, EMT, chemotherapy resistance mechanisms, and genetic manipulations and natural products to enhance the sensitivity of pancreatic cancer to chemotherapy. Additionally, it discusses small targeted molecules and pancreatic cancer trials, and nanotechnology-based drug delivery. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy is a valuable source for researchers and advanced students in cancer and oncology as well as clinicians and medical students who are interested in learning more about ways to break pancreatic cancer resistance to chemotherapy. Modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property by introducing new strategies and drugs Provides information about on-going research as well as clinical data on pancreatic cancer and detailed descriptions about therapeutic options for easy understanding Utilizes full color figures to help the understanding of the content and tables for easy comparison of information as well as quick access to it
Author |
: Zhe-Sheng Chen |
Publisher |
: Frontiers Media SA |
Total Pages |
: 428 |
Release |
: 2023-07-27 |
ISBN-10 |
: 9782832530030 |
ISBN-13 |
: 2832530036 |
Rating |
: 4/5 (30 Downloads) |
Synopsis Targeted cancer therapies, from small molecules to antibodies, volume II by : Zhe-Sheng Chen
Author |
: Khondaker Miraz Rahman |
Publisher |
: Royal Society of Chemistry |
Total Pages |
: 214 |
Release |
: 2018-09-06 |
ISBN-10 |
: 9781782621454 |
ISBN-13 |
: 1782621458 |
Rating |
: 4/5 (54 Downloads) |
Synopsis Small-Molecule Transcription Factor Inhibitors in Oncology by : Khondaker Miraz Rahman
This book highlights recent progress in the development of small-molecule inhibitors of oncogenic transcription factors and is relevant for postgraduates, researchers and practitioners.
Author |
: John Wing Shing Ho |
Publisher |
: |
Total Pages |
: 170 |
Release |
: 2019 |
ISBN-10 |
: 9814525634 |
ISBN-13 |
: 9789814525633 |
Rating |
: 4/5 (34 Downloads) |
Synopsis Naturally Occurring Small Molecules for Disease and Cancer Treatment by : John Wing Shing Ho
Author |
: Tod W. Speer |
Publisher |
: Lippincott Williams & Wilkins |
Total Pages |
: 564 |
Release |
: 2012-03-28 |
ISBN-10 |
: 9781451153262 |
ISBN-13 |
: 1451153260 |
Rating |
: 4/5 (62 Downloads) |
Synopsis Targeted Radionuclide Therapy by : Tod W. Speer
Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.