Slow Transmissible Diseases of the Nervous System

The term "unconventional virus" refers to virus-like agents that differ from conventional viruses in significant respects--resistance to agents that inactivate normal viruses, for example. Certain rare and fatal neurological disorders, such as the Creutzfeldt-Jacob syndrome and the Gerstmann-Straussler syndrome, are clearly produced by virus-like infectious agents, but the nature of these agents is not understood. This volume brings together the latest information on one such disease: Scrapie, a disease occurring in sheep. It discusses the nature of this infectious agent and insights gained through new techniques in molecular genetics. The work as a whole focuses on the implications of animal data for research on human disorders, such as the possible connection between unconventional viruses and Alzheimer's Disease. The discussions represent the work of specialists from a broad spectrum of fields including virology, neuropathology, and molecular biology.

Received document entitled: SERVICE OF COPY OF FIRST AMENDED COMPLAINT IN FEDERAL DISTRICT COURT

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

An updated volume focusing on human virology and incorporating knowledge that has been gained in recent years, including contemporary information on the molecular biology of viruses.

The highly anticipated second edition is now completely revised & expanded to provide thorough, encyclopedic coverage of pathophysiology, diagnosis, & surgical management of all disorders as it remains gold-standard in the specialty. 450 chapters encompass the entire field of neurosurgery, & since each chapter focuses on specific topic in a concise format, the reader can review a subject quickly yet thoroughly.