Simultaneous Statistical Inference, which was published originally in 1966 by McGraw-Hill Book Company, went out of print in 1973. Since then, it has been available from University Microfilms International in xerox form. With this new edition Springer-Verlag has republished the original edition along with my review article on multiple comparisons from the December 1977 issue of the Journal of the American Statistical Association. This review article covered developments in the field from 1966 through 1976. A few minor typographical errors in the original edition have been corrected in this new edition. A new table of critical points for the studentized maximum modulus is included in this second edition as an addendum. The original edition included the table by K. C. S. Pillai and K. V. Ramachandran, which was meager but the best available at the time. This edition contains the table published in Biometrika in 1971 by G. 1. Hahn and R. W. Hendrickson, which is far more comprehensive and therefore more useful. The typing was ably handled by Wanda Edminster for the review article and Karola Decleve for the changes for the second edition. My wife, Barbara, again cheerfully assisted in the proofreading. Fred Leone kindly granted permission from the American Statistical Association to reproduce my review article. Also, Gerald Hahn, Richard Hendrickson, and, for Biometrika, David Cox graciously granted permission to reproduce the new table of the studentized maximum modulus. The work in preparing the review article was partially supported by NIH Grant ROI GM21215.

This monograph will provide an in-depth mathematical treatment of modern multiple test procedures controlling the false discovery rate (FDR) and related error measures, particularly addressing applications to fields such as genetics, proteomics, neuroscience and general biology. The book will also include a detailed description how to implement these methods in practice. Moreover new developments focusing on non-standard assumptions are also included, especially multiple tests for discrete data. The book primarily addresses researchers and practitioners but will also be beneficial for graduate students.

Multiple Comparisons introduces simultaneous statistical inference and covers the theory and techniques for all-pairwise comparisons, multiple comparisons with the best, and multiple comparisons with a control. The author describes confidence intervals methods and stepwise exposes abuses and misconceptions, and guides readers to the correct method for each problem. Discussions also include the connections with bioequivalence, drug stability, and toxicity studies Real data sets analyzed by computer software packages illustrate the applications presented.

Simultaneous confidence bands enable more intuitive and detailed inference of regression analysis than the standard inferential methods of parameter estimation and hypothesis testing. Simultaneous Inference in Regression provides a thorough overview of the construction methods and applications of simultaneous confidence bands for various inferentia

We live in a new age for statistical inference, where modern scientific technology such as microarrays and fMRI machines routinely produce thousands and sometimes millions of parallel data sets, each with its own estimation or testing problem. Doing thousands of problems at once is more than repeated application of classical methods. Taking an empirical Bayes approach, Bradley Efron, inventor of the bootstrap, shows how information accrues across problems in a way that combines Bayesian and frequentist ideas. Estimation, testing and prediction blend in this framework, producing opportunities for new methodologies of increased power. New difficulties also arise, easily leading to flawed inferences. This book takes a careful look at both the promise and pitfalls of large-scale statistical inference, with particular attention to false discovery rates, the most successful of the new statistical techniques. Emphasis is on the inferential ideas underlying technical developments, illustrated using a large number of real examples.

Quantum statistical inference, a research field with deep roots in the foundations of both quantum physics and mathematical statistics, has made remarkable progress since 1990. In particular, its asymptotic theory has been developed during this period. However, there has hitherto been no book covering this remarkable progress after 1990; the famous textbooks by Holevo and Helstrom deal only with research results in the earlier stage (1960s-1970s).This book presents the important and recent results of quantum statistical inference. It focuses on the asymptotic theory, which is one of the central issues of mathematical statistics and had not been investigated in quantum statistical inference until the early 1980s. It contains outstanding papers after Holevo's textbook, some of which are of great importance but are not available now.The reader is expected to have only elementary mathematical knowledge, and therefore much of the content will be accessible to graduate students as well as research workers in related fields. Introductions to quantum statistical inference have been specially written for the book. Asymptotic Theory of Quantum Statistical Inference: Selected Papers will give the reader a new insight into physics and statistical inference.

Theory of Statistical Inference is designed as a reference on statistical inference for researchers and students at the graduate or advanced undergraduate level. It presents a unified treatment of the foundational ideas of modern statistical inference, and would be suitable for a core course in a graduate program in statistics or biostatistics. The emphasis is on the application of mathematical theory to the problem of inference, leading to an optimization theory allowing the choice of those statistical methods yielding the most efficient use of data. The book shows how a small number of key concepts, such as sufficiency, invariance, stochastic ordering, decision theory and vector space algebra play a recurring and unifying role. The volume can be divided into four sections. Part I provides a review of the required distribution theory. Part II introduces the problem of statistical inference. This includes the definitions of the exponential family, invariant and Bayesian models. Basic concepts of estimation, confidence intervals and hypothesis testing are introduced here. Part III constitutes the core of the volume, presenting a formal theory of statistical inference. Beginning with decision theory, this section then covers uniformly minimum variance unbiased (UMVU) estimation, minimum risk equivariant (MRE) estimation and the Neyman-Pearson test. Finally, Part IV introduces large sample theory. This section begins with stochastic limit theorems, the δ-method, the Bahadur representation theorem for sample quantiles, large sample U-estimation, the Cramér-Rao lower bound and asymptotic efficiency. A separate chapter is then devoted to estimating equation methods. The volume ends with a detailed development of large sample hypothesis testing, based on the likelihood ratio test (LRT), Rao score test and the Wald test. Features This volume includes treatment of linear and nonlinear regression models, ANOVA models, generalized linear models (GLM) and generalized estimating equations (GEE). An introduction to decision theory (including risk, admissibility, classification, Bayes and minimax decision rules) is presented. The importance of this sometimes overlooked topic to statistical methodology is emphasized. The volume emphasizes throughout the important role that can be played by group theory and invariance in statistical inference. Nonparametric (rank-based) methods are derived by the same principles used for parametric models and are therefore presented as solutions to well-defined mathematical problems, rather than as robust heuristic alternatives to parametric methods. Each chapter ends with a set of theoretical and applied exercises integrated with the main text. Problems involving R programming are included. Appendices summarize the necessary background in analysis, matrix algebra and group theory.

Adopting a unifying theme based on maximum statistics, Multiple Comparisons Using R describes the common underlying theory of multiple comparison procedures through numerous examples. It also presents a detailed description of available software implementations in R. The R packages and source code for the analyses are available at http://CRAN.R-project.org After giving examples of multiplicity problems, the book covers general concepts and basic multiple comparisons procedures, including the Bonferroni method and Simes’ test. It then shows how to perform parametric multiple comparisons in standard linear models and general parametric models. It also introduces the multcomp package in R, which offers a convenient interface to perform multiple comparisons in a general context. Following this theoretical framework, the book explores applications involving the Dunnett test, Tukey’s all pairwise comparisons, and general multiple contrast tests for standard regression models, mixed-effects models, and parametric survival models. The last chapter reviews other multiple comparison procedures, such as resampling-based procedures, methods for group sequential or adaptive designs, and the combination of multiple comparison procedures with modeling techniques. Controlling multiplicity in experiments ensures better decision making and safeguards against false claims. A self-contained introduction to multiple comparison procedures, this book offers strategies for constructing the procedures and illustrates the framework for multiple hypotheses testing in general parametric models. It is suitable for readers with R experience but limited knowledge of multiple comparison procedures and vice versa. See Dr. Bretz discuss the book.

In this definitive book, D. R. Cox gives a comprehensive and balanced appraisal of statistical inference. He develops the key concepts, describing and comparing the main ideas and controversies over foundational issues that have been keenly argued for more than two-hundred years. Continuing a sixty-year career of major contributions to statistical thought, no one is better placed to give this much-needed account of the field. An appendix gives a more personal assessment of the merits of different ideas. The content ranges from the traditional to the contemporary. While specific applications are not treated, the book is strongly motivated by applications across the sciences and associated technologies. The mathematics is kept as elementary as feasible, though previous knowledge of statistics is assumed. The book will be valued by every user or student of statistics who is serious about understanding the uncertainty inherent in conclusions from statistical analyses.

A coherent, unified set of statistical methods, based on ranks, for analyzing data resulting from various experimental designs. Uses MINITAB, a statistical computing system for the implementation of the methods. Assesses the statistical and stability properties of the methods through asymptotic efficiency and influence curves and tolerance values. Includes exercises and problems.