Signal Transduction And Human Disease
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Author |
: Toren Finkel |
Publisher |
: John Wiley & Sons |
Total Pages |
: 490 |
Release |
: 2003-07-18 |
ISBN-10 |
: 9780471448372 |
ISBN-13 |
: 0471448370 |
Rating |
: 4/5 (72 Downloads) |
Synopsis Signal Transduction and Human Disease by : Toren Finkel
This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.
Author |
: Ari Sitaramayya |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 429 |
Release |
: 2009-12-02 |
ISBN-10 |
: 9783642021121 |
ISBN-13 |
: 3642021123 |
Rating |
: 4/5 (21 Downloads) |
Synopsis Signal Transduction: Pathways, Mechanisms and Diseases by : Ari Sitaramayya
Providing an overview of recent developments in the field of signal transduction, this volume emphasizes direct clinical significance. As such, topics like nuclear receptors, apoptosis, growth factors, cell cycles and cancer are examined.
Author |
: Nariyoshi Shinomiya |
Publisher |
: Springer |
Total Pages |
: 0 |
Release |
: 2018-03-01 |
ISBN-10 |
: 9811072957 |
ISBN-13 |
: 9789811072956 |
Rating |
: 4/5 (57 Downloads) |
Synopsis Regulation of Signal Transduction in Human Cell Research by : Nariyoshi Shinomiya
This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders. Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on. This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area. This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.
Author |
: Lorenzo F. Greco |
Publisher |
: |
Total Pages |
: 0 |
Release |
: 2008 |
ISBN-10 |
: 1604563389 |
ISBN-13 |
: 9781604563382 |
Rating |
: 4/5 (89 Downloads) |
Synopsis Signal Transduction by : Lorenzo F. Greco
Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, auto-immune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms. This book presents the latest research in the field.
Author |
: Paul Greengard |
Publisher |
: Academic Press |
Total Pages |
: 336 |
Release |
: 1998-07 |
ISBN-10 |
: 0120361310 |
ISBN-13 |
: 9780120361311 |
Rating |
: 4/5 (10 Downloads) |
Synopsis Signal Transduction in Health and Disease by : Paul Greengard
This volume contains papers presented at the Ninth International Conference on Second Messengers and Phosphoproteins. Written by leading scientists - including two Nobel Laureates - the papers highlight contemporary advances in the rapidly evolving field of signal transduction. The findings presented are of vital significance to researchers in virtually all biomedical fields, including pharmacology, molecular biology, cell biology, biochemistry, the neurosciences, and physiology. The contributors offer new insights into fundamental cell signalling mechanisms and explore the role of these mechanisms in physiological and pathophysiological responses in a variety of systems. Coverage includes many topics that are currently under intensive study, such as growth factors and special signalling systems; protein phosphatases and metabolic pathways; calcium and ion channels; cyclic GMP and cyclic AMP; and receptors and G proteins.
Author |
: Gavin McAlpine |
Publisher |
: Nova Publishers |
Total Pages |
: 256 |
Release |
: 2007 |
ISBN-10 |
: 1600213766 |
ISBN-13 |
: 9781600213762 |
Rating |
: 4/5 (66 Downloads) |
Synopsis Focus on Signal Transduction Research by : Gavin McAlpine
Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.
Author |
: Anastasia P. Nesterova |
Publisher |
: Elsevier |
Total Pages |
: 734 |
Release |
: 2019-10-18 |
ISBN-10 |
: 9780128170878 |
ISBN-13 |
: 0128170875 |
Rating |
: 4/5 (78 Downloads) |
Synopsis Disease Pathways by : Anastasia P. Nesterova
Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. - Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. - Disease pathways are based on computational models from Elsevier's Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. - Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.
Author |
: Edward Bittar |
Publisher |
: Elsevier |
Total Pages |
: 269 |
Release |
: 2005-10-07 |
ISBN-10 |
: 9780080458601 |
ISBN-13 |
: 0080458602 |
Rating |
: 4/5 (01 Downloads) |
Synopsis Caveolae and Lipid Rafts: Roles in Signal Transduction and the Pathogenesis of Human Disease by : Edward Bittar
Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.
Author |
: Jennifer N. Meyers |
Publisher |
: Nova Publishers |
Total Pages |
: 270 |
Release |
: 2007 |
ISBN-10 |
: 1600213758 |
ISBN-13 |
: 9781600213755 |
Rating |
: 4/5 (58 Downloads) |
Synopsis Trends in Signal Transduction Research by : Jennifer N. Meyers
Signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. In many transduction processes, an increasing number of enzymes and other molecules become engaged in the events that proceed from the initial stimulus. Responses of cells to environmental signals, toxins and stressors have profound implications for diverse aspects of human health and disease including development, cystic fibrosis, diabetes, asthma, heart, autoimmune diseases and cancer. The delineation of the signal transduction pathways affected in these and other complex human diseases are likely to present new avenues for therapeutic intervention and understanding of human disease mechanisms.
Author |
: Jonathan W. Boyd |
Publisher |
: John Wiley & Sons |
Total Pages |
: 336 |
Release |
: 2019-04-16 |
ISBN-10 |
: 9781119060260 |
ISBN-13 |
: 1119060265 |
Rating |
: 4/5 (60 Downloads) |
Synopsis Cellular Signal Transduction in Toxicology and Pharmacology by : Jonathan W. Boyd
Covering a key topic due to growing research into the role of signaling mechanisms in toxicology, this book focuses on practical approaches for informatics, big data, and complex data sets. Combines fundamentals / basics with experimental applications that can help those involved in preclinical drug studies and translational research Includes detailed presentations of study methodology and data collection, analysis, and interpretation Discusses tools like experimental design, sample handling, analytical measurement techniques