Packed with real-world examples, this book illustrates the 12 principles of green chemistry. These diverse case studies demonstrate to scientists and students that beyond the theory, the challenges of green chemistry in pharmaceutical discovery and development remain an ongoing endeavor. By informing and welcoming additional practitioners to this m

Packed with real-world examples, this book illustrates the 12 principles of green chemistry. These diverse case studies demonstrate to scientists and students that beyond the theory, the challenges of green chemistry in pharmaceutical discovery and development remain an ongoing endeavor. By informing and welcoming additional practitioners to this mission, the negative environmental impact of pharmaceutical products will continue to be minimized. Green chemistry is the methodology by which chemical production in this industry can become more efficient, adding environmental stewardship to the noble mission of treating human disease.

In recent years the need for sustainable process design and alternative reaction routes to reduce industry?s impact on the environment has gained vital importance. The book begins with a general overview of new trends in designing industrial chemical processes which are environmentally friendly and economically feasible. Specific examples written by experts from industry cover the possibilities of running industrial chemical processes in a sustainable manner and provide an up-to-date insight into the main concerns, e.g., the use of renewable raw materials, the use of alternative energy sources in chemical processes, the design of intrinsically safe processes, microreactor and integrated reaction/ separation technologies, process intensification, waste reduction, new catalytic routes and/or solvent and process optimization.

An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.

Mimicking nature's efficiency and sustainability in organic chemistry is a major goal for future chemists; redox reactions are a key element in a variety of fields ranging from synthesis and catalysis to materials chemistry and analytical applications. Sustainability is increasingly becoming a consideration in synthesis and functional chemistry and an essential element for the next generation of chemistry in academia and industry. This book represents a compilation of the latest advancements in functional redox chemistry and demonstrates its importance in achieving a more sustainable future. This book is an ideal companion for any postgraduate students or researchers interested in sustainability in academia and industry.

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. - Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability - Reflects on techniques for a broad range of compounds and materials - Highlights sustainable and green chemistry pathways for molecular synthesis

Synthesis of Metal-Organic Frameworks via Water-Based Routes: A Green and Sustainable Approach describes a sustainable approach for the synthesis of metal-organic frameworks. Bringing together chapters on the aqueous synthesis and stability of metal-organic frameworks, as well as the applications of water stable metal-organic frameworks, this timely book shows how green processing technology utilizing water as a main solvent for the synthesis of metal-organic frameworks can eliminate solvent consumption, lower investment costs and reduce energy requirements. Providing quantitative descriptions and reliable guidelines, the book summarizes the fundamental approaches and principles to prepare metal-organic frame works, highlighting the most exciting preparations and applications. - Includes the role of water in metal organic synthesis - Describes various methods of metal-organic framework preparation - Covers the industrial aspects of water-based metal-organic frameworks and potential applications

This unique volume describes advances in the field of mechanochemistry, in particular the scaling up of mechanochemical processes. Scalable techniques employed to carry out solvent-free synthesis are evaluated. Comparability to continuous flow chemistry, the current industrial benchmark for continuous efficient chemical synthesis, is presented.The book concludes that mechanochemical synthesis can be scaled up into a continuous, sustainable process. It demonstrates that large-scale mechanochemistry can meet industrial demands, especially in the pharmaceutical industry. Features Mechanochemistry is rapidly developing as a multidisciplinary science on the borderline between chemistry, materials science and environmental science This unique text focuses on mechanochemistry with the ability to scale up and illustrates how mechanochemical synthesis is no longer an obstacle This timely book highlights recent advancements describing what can be achieved in chemical synthesis Mechanochemistry enables the synthesis of multiple polymorphic crystalline forms in the production of drugs in the form of tablets or granules in capsules

Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.

Environmental sustainability creates both tremendous business opportunities and formidable threats to established companies across virtually all industry sectors. Yet many companies tackle the issue in a superficial or passive way, rather than considering fundamental changes to their existing business models. By ignoring the opportunities of Green Business Model Transformations, companies exclude themselves from a large variety of potential means to create economic value. In addition to ordinary product and process innovations, they can change “the rules of the game” within an industry towards environmental sustainability. Green Business Model Transformations, however, are challenging ventures: New, green business models with all their uncertainties and inherent complex systemic characteristics are difficult to design, assess, and implement successfully, particularly in the context of established companies that often entail complex structures and considerable inertia. As a result, there is a great need for guidance in management practice. This publication addresses this need with a general approach to Managing Green Business Model Transformations that is based on a broad theoretical foundation, illustrated by many real-world examples from various industry sectors.