Role of RNA in Molecular Diagnostics of Cancer
Author | : Cesar Wong |
Publisher | : Frontiers Media SA |
Total Pages | : 130 |
Release | : 2020-07-01 |
ISBN-10 | : 9782889638130 |
ISBN-13 | : 2889638138 |
Rating | : 4/5 (30 Downloads) |
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Author | : Cesar Wong |
Publisher | : Frontiers Media SA |
Total Pages | : 130 |
Release | : 2020-07-01 |
ISBN-10 | : 9782889638130 |
ISBN-13 | : 2889638138 |
Rating | : 4/5 (30 Downloads) |
Author | : Andreas Keller |
Publisher | : John Wiley & Sons |
Total Pages | : 390 |
Release | : 2015-01-12 |
ISBN-10 | : 9783527335565 |
ISBN-13 | : 3527335560 |
Rating | : 4/5 (65 Downloads) |
By integrating technology, supporting infrastructure and efficient application, the all-in-one guide presents molecular diagnostics as an essential component of modern, personalized clinical practice. It considers all important aspects, from the hardware and software needed, to recent improvements in blood- and non-blood-based biomarker tests. Chapters on ethical challenges and a look at current trends and the latest innovations are also included. Bridging the gap between industry and academia, this is a highly useful resource for practitioners as well as for developers of modern, DNA- and RNA-based molecular diagnostics.
Author | : P.B. Raghavendra |
Publisher | : Academic Press |
Total Pages | : 300 |
Release | : 2018-01-02 |
ISBN-10 | : 9780128136805 |
ISBN-13 | : 0128136804 |
Rating | : 4/5 (05 Downloads) |
Advances in Cell and Molecular Diagnostics brings the scientific advances in the translation and validation of cellular and molecular discoveries in medicine into the clinical diagnostic setting. It enumerates the description and application of technological advances in the field of cellular and molecular diagnostic medicine, providing an overview of specialized fields, such as biomarker, genetic marker, screening, DNA-profiling, NGS, cytogenetics, transcriptome, cancer biomarkers, prostate specific antigen, and biomarker toxicologies. In addition, it presents novel discoveries and clinical pathologic correlations, including studies in oncology, infectious diseases, inherited diseases, predisposition to disease, and the description or polymorphisms linked to disease states. This book is a valuable resource for oncologists, practitioners and several members of the biomedical field who are interested in understanding how to apply cutting-edge technologies into diagnostics and healthcare. - Encompasses the current scientific advances in the translation and validation of cellular and molecular discoveries into the clinical diagnostic setting - Explains the application of cellular and molecular diagnostics methodologies in clinical trials - Focuses on translating preclinical tests to the bedside in order to help readers apply the most recent technologies to healthcare
Author | : Jane Y. Wu |
Publisher | : Springer Science & Business Media |
Total Pages | : 256 |
Release | : 2013-03-12 |
ISBN-10 | : 9783642316593 |
ISBN-13 | : 364231659X |
Rating | : 4/5 (93 Downloads) |
Accumulating evidence supports the role of defects in post-transcriptional gene regulation in the development of cancer. RNA and Cancer examines the recent advances in our understanding of post-transcriptional gene regulation, especially RNA processing and its role in cancer development and treatment. A particular focus is mRNA splicing, but other topics such as microRNAs, mRNA stability, the perinucleolar compartment, and oligonucleotide therapeutics are also covered in detail. All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers to the benefit of patients.
Author | : Nader Rifai |
Publisher | : Elsevier |
Total Pages | : 424 |
Release | : 2018-06-13 |
ISBN-10 | : 9780128160626 |
ISBN-13 | : 0128160624 |
Rating | : 4/5 (26 Downloads) |
Principles and Applications of Molecular Diagnostics serves as a comprehensive guide for clinical laboratory professionals applying molecular technology to clinical diagnosis. The first half of the book covers principles and analytical concepts in molecular diagnostics such as genomes and variants, nucleic acids isolation and amplification methods, and measurement techniques, circulating tumor cells, and plasma DNA; the second half presents clinical applications of molecular diagnostics in genetic disease, infectious disease, hematopoietic malignancies, solid tumors, prenatal diagnosis, pharmacogenetics, and identity testing. A thorough yet succinct guide to using molecular testing technology, Principles and Applications of Molecular Diagnostics is an essential resource for laboratory professionals, biologists, chemists, pharmaceutical and biotech researchers, and manufacturers of molecular diagnostics kits and instruments. - Explains the principles and tools of molecular biology - Describes standard and state-of-the-art molecular techniques for obtaining qualitative and quantitative results - Provides a detailed description of current molecular applications used to solve diagnostics tasks
Author | : Christoph Wagener |
Publisher | : Springer Science & Business Media |
Total Pages | : 214 |
Release | : 2012-12-06 |
ISBN-10 | : 9783642775215 |
ISBN-13 | : 3642775217 |
Rating | : 4/5 (15 Downloads) |
Present and potential future applications of new diagnostic strategies basedon the direct or indirect detection of cancer genes are delineated in this volume. Among the methodological aspects covered are enzymatic target amplification by the polymerase chain reaction and related techniques, DNA fingerprinting, transfer of putative cancer genes in appropriate receipient cells, and recent developments inthe application of monoclonal antibodies in immunohistochemistry and immunoscintigraphy. The diagnostic and functional implications of mutations in cancer genes such as ras and p53 are described. The characterization of cancer genes and their products is correlated with growth control anddissemination of tumour cells by in vitro or clinical evidence. The contributions in the present volume uptdate the information available on established or newly described cancer genes, and may help manage the transition from basic research to clinical practice.
Author | : Dongfeng Tan |
Publisher | : Lippincott Williams & Wilkins |
Total Pages | : 2177 |
Release | : 2012-12-07 |
ISBN-10 | : 9781469820644 |
ISBN-13 | : 1469820641 |
Rating | : 4/5 (44 Downloads) |
The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.
Author | : Subash Gupta |
Publisher | : Academic Press |
Total Pages | : 479 |
Release | : 2022-01-19 |
ISBN-10 | : 9780128245514 |
ISBN-13 | : 0128245514 |
Rating | : 4/5 (14 Downloads) |
Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types. - Presents a beginning chapter summary to help readers understand the content thoroughly - Encompasses detailed description of information from clinical studies on noncoding RNAs in cancer therapy - Discusses one cancer type per chapter making the content easy to reference
Author | : Volker A. Erdmann |
Publisher | : Springer |
Total Pages | : 353 |
Release | : 2015-06-10 |
ISBN-10 | : 9783319173054 |
ISBN-13 | : 3319173057 |
Rating | : 4/5 (54 Downloads) |
The aim of molecular diagnostics is preferentially to detect a developing disease before any symptoms appear. There has been a significant increase, fueled by technologies from the human genome project, in the availability of nucleic acid sequence information for all living organisms including bacteria and viruses. When combined with a different type of instrumentation applied, the resulting diagnostics is specific and sensitive. Nucleic acid-based medical diagnosis detects specific DNAs or RNAs from the infecting organism or virus and a specific gene or the expression of a gene associated with a disease. Nucleic acid approaches also stimulate a basic science by opening lines of inquiry that will lead to greater understanding of the molecules at the center of life. One can follow Richard Feynman’s famous statement “What I cannot create, I do not understand.”
Author | : George P. Patrinos |
Publisher | : Academic Press |
Total Pages | : 526 |
Release | : 2016-10-27 |
ISBN-10 | : 9780128029886 |
ISBN-13 | : 0128029889 |
Rating | : 4/5 (86 Downloads) |
Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. - Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories - Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression - Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field