Reprogramming The Genome Crispr Cas Based Human Disease Therapy
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Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 394 |
Release |
: 2021-06-12 |
ISBN-10 |
: 9780323853248 |
ISBN-13 |
: 0323853242 |
Rating |
: 4/5 (48 Downloads) |
Synopsis Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy by :
Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy, presents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 is a key technology for targeted genome editing and regulation in a number of organisms including mammalian cells. It is a rapid, simple, and cost-effective solution. CRISPR-Cas system has recently gained much scientific and public attention. This volume covers CRISPR-Cas9 based mammalian genome editing, creating disease models, cancer therapy, neurological, heredity, blood disorders, defective gene correction, stem cells therapy, epigenetic modifications, patents, ethics, biosafety and regulatory issues challenges and opportunities. This book is a key source of information on mammalian genome editing available in a single volume. This book will be useful for beginners in mammalian genome editing and also students, researchers, scientists, policymakers, clinicians and stakeholders interested in genome editing in several areas. - Offers basic understanding and a clear picture of mammalian genome editing through CRISPR-Cas systems - Discusses how to create mammalian disease models, stem cell modification, epigenetic modifications, correction of defective gene in blood disorders, heredity, neurological disorders and many more - Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, molecular biology, translational sciences, neurobiology, neurology, cancer, stem cells, and many more
Author |
: Luis María Vaschetto |
Publisher |
: CRC Press |
Total Pages |
: 268 |
Release |
: 2022-01-31 |
ISBN-10 |
: 9781000540819 |
ISBN-13 |
: 1000540812 |
Rating |
: 4/5 (19 Downloads) |
Synopsis CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases by : Luis María Vaschetto
The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.
Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 560 |
Release |
: 2021-06-24 |
ISBN-10 |
: 9780323853026 |
ISBN-13 |
: 0323853021 |
Rating |
: 4/5 (26 Downloads) |
Synopsis Curing Genetic Diseases through Genome Reprogramming by :
Curing Genetic Diseases through Genome Reprogramming, Volume 182 captures an historic moment in the field of gene therapy—the dawn of a new age in which the dream of curing genetic diseases has become realizable. The volume presents the most clinically advanced gene therapy and genome editing approaches for the treatment of genetic diseases in specific organs, including difficult therapeutic targets, futuristic ideas of genetic interventions, and large scale human genome repair. An initial chapter addresses the complex ethical aspects involved in the very idea of modifying the human genome. - Provides a comprehensive view of gene therapy and genome editing technologies, including epigenetic editing - Describes the state-of-the-art and future directions for the treatment of genetic diseases, also considering economical aspects - Presents chapters that each give a thorough review of a specific disease, target organ or visionary approach, including ethical considerations
Author |
: |
Publisher |
: Elsevier |
Total Pages |
: 310 |
Release |
: 2024-09-11 |
ISBN-10 |
: 9780443315893 |
ISBN-13 |
: 0443315892 |
Rating |
: 4/5 (93 Downloads) |
Synopsis CRISPR-Cas-Based Genome Editing for Treating Human Diseases-Part A by :
CRISPR-Cas-Based Genome Editing for Treating Human Diseases-Part A, Volume 208 represents CRISPR-Cas systems for genome editing. Currently, CRISPR-Cas systems are proven a key technology for targeted genome editing, which is acting as a simple, rapid, and cost-effective solution. CRISPR-Cas9 system is being used in microbial genome editing, mammalian genome editing, disease models, and more. It has shown potential in human disease treatment. However, it is not easy to find CRISPR-Cas systems genome editing in a single source.This volume offers CRISPR-Cas systems for human diseases, bacterial disease, gut microbiome editing, viral disease, protozoan disease, fungal disease, stem cell therapy, CRISPR in epigenetics, CRISPR in cancer, autoimmune and blood disorders. In addition, it highlights a number of aspects of the CRISPR-Cas systems that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest. - Updares on CRISPR-Cas systems for human diseases, bacterial disease, gut microbiome editing, viral disease, protozoan disease and fungal disease - Discusses stem cell therapy, CRISPR in epigenetics, CRISPR in cancer, autoimmune and blood disorders - Includes commentary on CRISPR in autoimmune and blood disorders
Author |
: Rodolphe Barrangou |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 300 |
Release |
: 2012-12-13 |
ISBN-10 |
: 9783642346576 |
ISBN-13 |
: 364234657X |
Rating |
: 4/5 (76 Downloads) |
Synopsis CRISPR-Cas Systems by : Rodolphe Barrangou
CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.
Author |
: |
Publisher |
: Elsevier |
Total Pages |
: 308 |
Release |
: 2024-10 |
ISBN-10 |
: 9780443315886 |
ISBN-13 |
: 0443315884 |
Rating |
: 4/5 (86 Downloads) |
Synopsis CRISPR-Cas-Based Genome Editing for Treating Human Diseases-Part A by :
CRISPR-Cas-Based Genome Editing for Treating Human Diseases-Part A, Volume 208 represents CRISPR-Cas systems for genome editing. Currently, CRISPR-Cas systems are proven a key technology for targeted genome editing, which is acting as a simple, rapid, and cost-effective solution. CRISPR-Cas9 system is being used in microbial genome editing, mammalian genome editing, disease models, and more. It has shown potential in human disease treatment. However, it is not easy to find CRISPR-Cas systems genome editing in a single source. This volume offers CRISPR-Cas systems for human diseases, bacterial disease, gut microbiome editing, viral disease, protozoan disease, fungal disease, stem cell therapy, CRISPR in epigenetics, CRISPR in cancer, autoimmune and blood disorders. In addition, it highlights a number of aspects of the CRISPR-Cas systems that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest.
Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 244 |
Release |
: 2021-03-28 |
ISBN-10 |
: 9780323853224 |
ISBN-13 |
: 0323853226 |
Rating |
: 4/5 (24 Downloads) |
Synopsis Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part A by :
Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems, Part A presents a collation of chapters written by global, eminent scientists. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. Chapters in this release include An Introduction and applications of CRISPR-Cas Systems, History, evolution and classification of CRISPR-Cas associated systems, CRISPR based bacterial genome editing and removal of pathogens, CRISPR based genome editing and removal of human viruses, CRISPR based development of RNA editing and diagnostic platform, and much more. Additional sections cover Genome engineering in insects for control of vector borne diseases, Development of insect cell line using CRISPR technology, CRISPRing protozoan parasites to better understand the biology of diseases, CRISPR based genome editing of Caenorhabditis elegans, and a variety of other important topics. - Offers a basic understanding and clear picture of genome editing CRISPR-Cas systems in different organisms - Explains how to create an animal model for disease diagnosis/research and reprogram CRISPR for removal of virus, bacteria, fungi, protozoan, and many more - Discusses the advances, patents, applications, challenges and opportunities in CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, and many more
Author |
: The Royal Society |
Publisher |
: National Academies Press |
Total Pages |
: 239 |
Release |
: 2021-01-16 |
ISBN-10 |
: 9780309671132 |
ISBN-13 |
: 0309671132 |
Rating |
: 4/5 (32 Downloads) |
Synopsis Heritable Human Genome Editing by : The Royal Society
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Author |
: |
Publisher |
: Academic Press |
Total Pages |
: 200 |
Release |
: 2021-04-29 |
ISBN-10 |
: 9780323852982 |
ISBN-13 |
: 032385298X |
Rating |
: 4/5 (82 Downloads) |
Synopsis Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part B by :
Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems Part B, represents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. It is a simple, rapid, precise, and cost-effective tool for genome editing and regulation of a wide range of organisms. It has gained scientific and public attention worldwide. This volume mainly covers insect cell line, protozoans, zebrafish, drosophila, CRISPRi, patents as well as technology transfer, and many more. This book is a key source of information available in a single volume. This book will be useful for not only beginners in genome engineering, but also students, researchers, scientists, policymakers, and stakeholders interested in harnessing the potential of reprogramming of the genomes in several areas. - Offers basic understanding and a clear picture of genome editing CRISPR-Cas systems in different organisms - Explains how to create an animal model for disease diagnosis/research and reprogram CRISPR for insect cell line, protozoans, zebrafish, drosophila, and many more - Discusses the advances, patents, applications, challenges and opportunities in CRISPR-Cas9 systems in basic sciences, biomedicine, molecular biology and many more
Author |
: Stephen H. Tsang |
Publisher |
: Academic Press |
Total Pages |
: 138 |
Release |
: 2021-10-20 |
ISBN-10 |
: 9780128178775 |
ISBN-13 |
: 0128178779 |
Rating |
: 4/5 (75 Downloads) |
Synopsis CRISPR Genome Surgery in Stem Cells and Disease Tissues by : Stephen H. Tsang
CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature. - Provides a thorough review of CRISPR-Cas9, from discovery to therapy - Covers the latest advances in gene editing and its translational applications to various diseases - Written by global leaders in the fields of gene editing and stem cell therapy