This book presents the latest advances in the field of regenerative medicine in plastic surgery. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner.The first part introduces readers to essential principles of skin and soft tissue regeneration, e.g. the possibility of using mesenchymal stem cells for wound healing. Since bone serves as a supportive tissue in most of the body, bone regeneration is an important aspect of regenerative medicine; accordingly, the second part discusses the novel bone implants, activated bone grafts and bone tissue engineering. The book’s third part, focusing on cartilage regeneration, includes chapters on e.g. stem cells and ear regeneration. In turn, part four addresses muscle and tendon regeneration: from tendon to bone and tendon to muscle, as well as aging in the realm of muscle regeneration. Lastly, part five highlights nerve regeneration, deepening surgeons’ knowledge to help them successfully treat injuries to the peripheral neural system. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "With beautiful clinical images and artwork, this book will be a central companion to both practicing plastic surgeons who wish to remain abreast of oncoming technologic advances and regenerative medicine researchers who wish to understand the current state of the art of surgical reconstruction." - Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine

This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields." - Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine

This book presents the state-of-art in regenerative procedures currently applied by aesthetic physicians, plastic surgeons and dermatologists. It is divided into two parts, the first of which provides a detailed introduction to aesthetic medicine and the aging process. The second part, in turn, addresses the current status of techniques and technologies with regard to autologous grafts, covering fat transfer, blood grafts, skin grafts and stem cells. The book examines the surgical applications of these grafts, as well as potential side effects and limitations. Therapy combinations and outcomes round out the coverage. Aesthetic physicians, plastic surgeons and dermatologists interested in performing regenerative procedures for aesthetic purposes will find this book to be a valuable guide.

This book is unique in focusing expressly on regenerative medicine in the aesthetic field. With the aid of more than 400 color pictures, it provides step-by-step descriptions of procedures that can be performed easily in the private practice. The number of people pursuing anti-aging and cosmetic procedures in order to achieve a youthful, healthy, or simply improved aspect is continually increasing. At the same time the available techniques and materials have undergone rapid innovation in terms of both safety and quality. The practitioner no longer looks just at the correction or camouflage of an unwanted feature but rather also aims to address the aging process itself. Regenerative medicine appears to provide a unique and unlimited opportunity in this context. Autologous fat grafting, adipose-derived stem cells, and autologous platelet-rich plasma represent just some of the attractive options that can be used for volume restoration and facial rejuvenation.

Physicians are now in a position pro-actively to use stem cells and their growth factors to regenerate the human body. Within the field of aesthetics, regenerative medicine is being used to reverse the ageing of tissues and to repair scarring to an unprecedented level. This highly illustrated text from an internationally recognized expert in cosmetic procedures documents the procedures and results for patients.

"Regenerating damaged organs and tissues, an act that once was considered magic, is currently entrusted to the surgeons who have allowed us to move from replacement and reconstructive plastic surgery to regenerative plastic surgery, through autologous and allogeneic cell-based therapies and growth factors. The enthusiasm for regenerative plastic surgery and for the treatment of some pathologies addressed by it, such as breast reconstruction, hemifacial atrophy, burns, scars, and aesthetic improvements such as breast and buttock augmentation, face rejuvenation and hair regrowth, has led the author, Professor Pietro Gentile, to rigorously investigate the possible new minimally invasive strategies based on adipose-derived stem cells, human follicle stem cells and growth factors contained in platelet-rich plasma. This book reports on the latest knowledge regarding the treatment of soft and bone tissue defects. Therefore, the goal of this text is to introduce and definitively establish this new and interesting field of plastic surgery, called regenerative plastic surgery"--

3D Bioprinting for Reconstructive Surgery: Techniques and Applications examines the combined use of materials, procedures and tools necessary for creating structural tissue constructs for reconstructive purposes. Offering a broad analysis of the field, the first set of chapters review the range of biomaterials which can be used to create 3D-printed tissue constructs. Part Two looks at the techniques needed to prepare biomaterials and biological materials for 3D printing, while the final set of chapters examines application-specific examples of tissues formed from 3D printed biomaterials. 3D printing of biomaterials for tissue engineering applications is becoming increasingly popular due to its ability to offer unique, patient-specific parts—on demand—at a relatively low cost. This book is a valuable resource for biomaterials scientists, biomedical engineers, practitioners and students wishing to broaden their knowledge in the allied field. - Discusses new possibilities in tissue engineering with 3D printing - Presents a comprehensive coverage of the materials, techniques and tools needed for producing bioprinted tissues - Reviews emerging technologies in addition to commercial techniques

"New techniques in regenerative facial surgery are among the hottest topics in the world of aesthetics. Yet the terminology has been confusing, and no standards of treatment have been introduced into the field. Nanofat, injectable tissue replacement and regeneration, stromal vascular fraction, exosomes, platelet-rich plasma, and mechanical devices that minimally manipulate fat and blood to retrieve certain cells and cell-matrix aggregates are used in the management of facial aging. What all regenerative treatments have in common is the creation to some degree of neoangiogenesis, collagen and elastin remodeling, and immune modulation of inflammation. Regenerative facial surgery aims to restore and reconstruct youth by anatomic repositioning to address laxity, facial fat grafting to target volume losses, and a variety of newer, regenerative strategies to reverse sun damage and skin aging. The rapidly rising use of these promising techniques in facial surgery requires knowledge of how the facial anatomy changes during the aging process, how to diagnose the precise areas of fat and bone loss, and how to combine these exciting new regenerative approaches alone and in combination with skin care, lasers, energy-based devices, and surgery to not only aesthetically benefit the patient, but also to regenerate tissues, slow, and possibly even reverse some of the components of facial aging. This unique book brings readers the essentials of the clinical practice of regenerative facial surgery by some of the field's earliest pioneers"--

Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis and Poland syndrome. In addition, potential risks and complications are identified. The book has been written by leading experts and will be an invaluable source of information for students, beginners and experienced surgeons in a range of specialties.

Patient specific and disease specific stem cell lines have already introduced groundbreaking advances into the research and practice of ophthalmology. This volume provides a comprehensive and engaging overview of the latest innovations in the field. Twelve chapters discuss the fastest growing areas in ophthalmological stem cell research, from disease modelling, drug screening and gene targeting to clinical genetics and regenerative treatments. Innovative results from stem cell research of the past decade are pointing the way toward practicable treatments for retinitis pigmentosa, age related macular degeneration, and Stargardt disease. What future directions will stem cell research take? Researchers, graduate students, and fellows alike will find food for thought in this insightful guide tapping into the collective knowledge of leaders in the field. Stem Cells in Ophthalmology is part of the Stem Cells in Regenerative Medicine series dedicated to discussing current challenges and future directions in stem cell research.