Receptor Endocytosis and Signalling in Health and Disease, Part B, Volume 196 highlights the different aspects of receptor endocytosis and signaling, covering several receptors which are associated with different organs and that play a key role in normal functioning in the body, including somatostatin, Mas receptor, AMPA, Dopamine, 5-HT1-2, GABA, GPCR, nuclear receptor, Integrin, BCR, CRHR1, etc. Chapters in this new release include Internalization of somatostatin receptors in brain and periphery, Mas receptor, signaling and trafficking in health and disease, Endocytosis of AMPA receptors: Role in neurological conditions, Endocytosis of dopamine receptor: Signaling in brain, and more. Additional chapters cover Endocytosis of LXRs: Signalling in liver, Endocytosis of LDL receptor: Importance in cardiovascular diseases, Advances in the molecular level understanding of G-protein-coupled receptor, Nuclear receptor: Structure and function, Integrin receptor trafficking in health and disease, B Cell Receptor (BCR) endocytosis,CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling, and much more. - Provides information on the structure and function of nuclear receptors - Discusses the basic pathways involved in receptor internalization, subcellular trafficking, metabolic degradation, and signaling - Includes a wide range of neurological receptors and their roles

Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field. Chapters in this release include An overview on receptor endocytosis and signaling, Signaling molecules: Importance in health and disease conditions, Emerging tools for studying of receptor endocytosis and signaling, Endocytosis of EGFR: Signalling in cancer, Endocytosis of AT1 and AT2 receptors: Signalling in the kidney, Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants, Endocytosis of Insulin receptor: Signalling in the regulation of glucose homeostasis, Endocytosis of VEGFR: Role in the regulation of angiogenesis, and more. Other sections in this new release include Lymphocyte and monocyte/macrophage receptors mediating immune recognition of tumors, Lymphocyte and monocyte/macrophage receptors triggering immune suppression of tumor immunity, Prion receptors and prion internalization and intra- and inter-cellular transport, Multifunctional role of the ubiquitin proteasome pathway in phagocytosis, Adrenoceptors and SCD1 in adipocytes/adipose tissues: the expression and variation in health and obesity, Frizzled receptors and SFRP5 in lipid metabolism: current findings and potential applications. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Progress in Molecular Biology and Translational Science series - Includes the latest information on Receptor Endocytosis and Signaling in Health and Disease

Progress in Molecular Biology and Translational Science, Volume 159, provides the most topical, informative and exciting monographs available on a wide variety of research topics related to prions, viruses, bacteria and eukaryotes. The series includes in-depth knowledge on molecular biological aspects of organismal physiology, along with insights on how this knowledge may be applied to understand and ameliorate human disease. New chapters in this release discuss timely topics, such as Targeting recently deorphanized GPR83 for the treatment of infection, stress, and drug addiction, Arrestin Structure-Function, Arrestins in the Cardiovascular System, Analysis of biased agonism, and more. - Includes comprehensive coverage of molecular biology - Presents ample use of tables, diagrams, schemata, and color figures to enhance the reader's ability to rapidly grasp the information provided - Contains contributions from renowned experts in the field

In this book, skilled experts provide the most up-to-date, step-by-step laboratory protocols for examining molecular machinery and biological functions of exocytosis and endocytosis in vitro and in vivo. The book is insightful to both newcomers and seasoned professionals. It offers a unique and highly practical guide to versatile laboratory tools developed to study various aspects of intracellular vesicle trafficking in simple model systems and living organisms.

This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Receptor Endocytosis and Signalling in Health and Disease, Part B, Volume 196 highlights the different aspects of receptor endocytosis and signaling, covering several receptors which are associated with different organs and that play a key role in normal functioning in the body, including somatostatin, Mas receptor, AMPA, Dopamine, 5-HT1-2, GABA, GPCR, nuclear receptor, Integrin, BCR, CRHR1, etc. Chapters in this new release include Internalization of somatostatin receptors in brain and periphery, Mas receptor, signaling and trafficking in health and disease, Endocytosis of AMPA receptors: Role in neurological conditions, Endocytosis of dopamine receptor: Signaling in brain, and more. Additional chapters cover Endocytosis of LXRs: Signalling in liver, Endocytosis of LDL receptor: Importance in cardiovascular diseases, Advances in the molecular level understanding of G-protein-coupled receptor, Nuclear receptor: Structure and function, Integrin receptor trafficking in health and disease, B Cell Receptor (BCR) endocytosis,CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling, and much more.

This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Receptor Endocytosis and Signalling in Health and Disease, Part B, Volume 196 highlights the different aspects of receptor endocytosis and signaling, covering several receptors which are associated with different organs and that play a key role in normal functioning in the body, including somatostatin, Mas receptor, AMPA, Dopamine, 5-HT1-2, GABA, GPCR, nuclear receptor, Integrin, BCR, CRHR1, etc. Chapters in this new release include Internalization of somatostatin receptors in brain and periphery, Mas receptor, signaling and trafficking in health and disease, Endocytosis of AMPA receptors: Role in neurological conditions, Endocytosis of dopamine receptor: Signaling in brain, and more. Additional chapters cover Endocytosis of LXRs: Signalling in liver, Endocytosis of LDL receptor: Importance in cardiovascular diseases, Advances in the molecular level understanding of G-protein-coupled receptor, Nuclear receptor: Structure and function, Integrin receptor trafficking in health and disease, B Cell Receptor (BCR) endocytosis,CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling, and much more.