Recent Trends In Cancer Biology Spotlight On Signaling Cascades And Micrornas
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Author |
: Sundas Fayyaz |
Publisher |
: Springer |
Total Pages |
: 310 |
Release |
: 2018-03-07 |
ISBN-10 |
: 9783319715537 |
ISBN-13 |
: 3319715534 |
Rating |
: 4/5 (37 Downloads) |
Synopsis Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs by : Sundas Fayyaz
Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.
Author |
: DKV Prasad |
Publisher |
: Springer Nature |
Total Pages |
: 183 |
Release |
: 2022-06-07 |
ISBN-10 |
: 9789811691867 |
ISBN-13 |
: 981169186X |
Rating |
: 4/5 (67 Downloads) |
Synopsis Role of MicroRNAs in Cancers by : DKV Prasad
This book discusses the potential roles of miRNA as a crucial regulator in cancer biology. It examines the regulation of drug resistance by miRNAs in cancers and the mechanism of their deregulated expression. The book discusses the role and molecular mechanism of miRNA in regulating cellular proliferation and cell cycle. It analyses circulating miRNAs as biomarkers for cancer diagnosis and prognosis. It also analyzes the role of miRNA as a modulator of the development and function of tumor-associated immune cells. It explores the cross-talk between miRNA and reactive oxygen species (ROS) in pathogenesis, cancer therapeutic tolerance, and resistance. It provides insights into the role of miRNA in cancer angiogenesis, metastasis and describes strategies and associated challenges of miRNA-based therapies.
Author |
: David M. Terrian |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 330 |
Release |
: 2008-02-05 |
ISBN-10 |
: 9781592593569 |
ISBN-13 |
: 1592593569 |
Rating |
: 4/5 (69 Downloads) |
Synopsis Cancer Cell Signaling by : David M. Terrian
Cells respond to environmental cues through a complex and dynamic network of signaling pathways that normally maintain a critical balance between cellular proliferation, differentiation, senescence, and death. One current research challenge is to identify those aberrations in signal transd- tion that directly contribute to a loss of this division-limited equilibrium and the progression to malignant transformation. The study of cell-signaling m- ecules in this context is a central component of cancer research. From the knowledge of such targets, investigators have been able to productively advance many insightful hypotheses about how a particular cancer cell may misinterpret, or respond inappropriately to, growth regulatory cues in their environment. Despite these key insights, the rapidly evolving nature of cell signaling research in cancer has necessitated a continuous revision of these theoretical constructs and the updating of methods used in their study. One contemporary example of the evolution of this field is provided by an analysis of the Human Genome Project data, which reveal a previously unsuspected diversity in the multigene families encoding for most signaling pathway int- mediates. In assessing the usefulness of a particular methodological approach, therefore, we will need to keep in mind that there is a premium on those p- tocols that can be easily adapted for the analysis of multiple members within a gene family. Cancer Cell Signaling: Methods and Protocols brings together several such methods in cell signaling research that are scientifically grounded within the cancer biology field.
Author |
: Suresh Alahari |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 149 |
Release |
: 2012-08-01 |
ISBN-10 |
: 9789400746558 |
ISBN-13 |
: 9400746555 |
Rating |
: 4/5 (58 Downloads) |
Synopsis MicroRNA in Cancer by : Suresh Alahari
The field of microRNA biology is really emerging in the last couple of years. Several investigators highlighted the importance of miRNAs in cancer. Although there is so much literature on microRNAs exist, a comprehensive book is still not available. Thus this book will be a great use to the scientists in the field of cancer biology. In addition, this book will be a good source of information for undergraduate, graduate students who want to develop their research careers in cancer biology.
Author |
: Sadegh Babashah |
Publisher |
: Springer |
Total Pages |
: 449 |
Release |
: 2014-07-08 |
ISBN-10 |
: 9783319037257 |
ISBN-13 |
: 3319037250 |
Rating |
: 4/5 (57 Downloads) |
Synopsis MicroRNAs: Key Regulators of Oncogenesis by : Sadegh Babashah
Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs have a crucial function in oncogenesis by regulating cell proliferation and apoptosis as oncogenes or tumor suppressors. The expression signatures of miRNAs provide exciting opportunities in the diagnosis, prognosis and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in oncogenesis, the potential of using these small RNAs as therapeutic targets opens up new opportunities for cancer therapy by either inhibiting or augmenting their activity.
Author |
: Zhe-Sheng Chen |
Publisher |
: Frontiers Media SA |
Total Pages |
: 393 |
Release |
: 2022-06-06 |
ISBN-10 |
: 9782889763344 |
ISBN-13 |
: 288976334X |
Rating |
: 4/5 (44 Downloads) |
Synopsis Chemo-Radiation-Resistance in Cancer Therapy by : Zhe-Sheng Chen
Author |
: Aamir Ahmad |
Publisher |
: Springer Nature |
Total Pages |
: 427 |
Release |
: 2019-08-27 |
ISBN-10 |
: 9783030203016 |
ISBN-13 |
: 3030203018 |
Rating |
: 4/5 (16 Downloads) |
Synopsis Breast Cancer Metastasis and Drug Resistance by : Aamir Ahmad
Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.
Author |
: Dragos Cretoiu |
Publisher |
: Frontiers Media SA |
Total Pages |
: 260 |
Release |
: 2020-12-29 |
ISBN-10 |
: 9782889662890 |
ISBN-13 |
: 2889662896 |
Rating |
: 4/5 (90 Downloads) |
Synopsis MicroRNA Signaling by : Dragos Cretoiu
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author |
: Thorsten Cramer |
Publisher |
: Springer |
Total Pages |
: 272 |
Release |
: 2016-08-24 |
ISBN-10 |
: 9783319421186 |
ISBN-13 |
: 3319421182 |
Rating |
: 4/5 (86 Downloads) |
Synopsis Metabolism in Cancer by : Thorsten Cramer
This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
Author |
: William J. Gradishar |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 230 |
Release |
: 2000-08-31 |
ISBN-10 |
: 0792378903 |
ISBN-13 |
: 9780792378907 |
Rating |
: 4/5 (03 Downloads) |
Synopsis Advances in Breast Cancer Management, 2nd edition by : William J. Gradishar
The optimal management of breast cancer patients relies on the expertise of a team of medical specialists including radiologists, surgeons, radiation therapists and medical oncologists. Much of the progress in breast cancer management made over the last several years reflects the translation of observations made in the laboratory to the clinic. Critically evaluating the impact of new treatment approaches relies on a commitment to well-designed clinical trials. In this volume, Advances in Breast Cancer Management, a renowned group of breast cancer experts have been asked to provide their perspective on management issues that directly effect patients on a day-to-day basis. Dr. Melody Cobleigh discusses the consequences of estrogen deprivation and the ways of ameliorating secondary symptoms and the potential long-term morbidity. Drs. Haigh and Guiliano review the sentinel lymph node biopsy technique including results from their extensive experience. Dr. Abram Recht places into perspective the potential benefit of post-mastectomy radiotherapy and reviews recent trials that address this issue. Dr. Dennis Slamon takes from us from the laboratory to the clinic in explaining the development of Herceptin as a paradigm for therapy targeted to specific molecular characteristics of breast cancer tumor cells. Drs. Nieto, Shpall, Crump and Pritchard offer different perspectives on the future of high-dose chemotherapy with stem cell transplantation as a treatment for breast cancer patients. Drs.