Among the topics covered in Volume 49 are neurotransmitter transporters circadian rhythms, transgenic model for studying isles development, protein phosphateses, the androgen receptor, molecular genetics of steroid 5oz-reductases and benign and malignant prostatic neoplasms.

Recent Progress in Hormone Research, Volume 25 presents the proceedings of the 26th meeting of the Laurentian Hormone Conference held in Mont Tremblant, Quebec, Canada, on August 23-29, 1968. The book presents papers on reproductive endocrinology (i.e. a model for the regulation of ovulation in the rat; comparative aspects of uterine-luteal relationships), proinsulin (i.e. proinsulin and the biosynthesis of insulin), and the secretion of hormones by tumors of nonendocrine origin (i.e. clinical and laboratory studies of ectopic humoral syndromes). The text also includes papers on the ultrastructure of the endocrine glands; on the thyroid (i.e. studies of the thyroid iodide ""trap"" in human); on neuroendocrinology (i.e. the mammalian pineal as a neuroendocrine transducer), and on steroid hormones (i.e. metabolic events associated with steroid hydroxylation by the adrenal cortex; and steroid dynamics under steady-state conditions). Endocrinologists and people involved in hormone research will find the book invaluable.

Recent Progress in Hormone Research, Volume 29 covers the proceedings of the 1972 Laurentian Hormone Conference held in Mont Tremblant, Province of Quebec, Canada, on August 27-September 1, 1972. The book discusses the studies on sex differentiation in mammals; male pseudohermaphroditism in the laboratory Norway rat; and androgen metabolism and mechanism of action in male pseudohermaphroditism. The text also describes the mechanism of initiation of parturition in the ewe; the neurovascular regulation of the anterior hypophysis; and microtubules and beta cell secretion. The role of microtubules and microfilaments in thyroid secretion; the functional and morphological alterations produced in target cells by anti-inflammatory steroids; and protein kinases are also considered. The book further tackles the role of phospholipids in hormone activation of adenylate cyclise; the chemistry of growth hormone and the lactogenic hormones; and hormonal regulation of gene expression in mammary cells. The text then encompasses the endocrine and metabolic effects of experimental obesity in human; the studies on luteinizing hormone and its subunits; and chemical studies of luteinizing hormone from human and ovine pituitaries. The studies on the structure and function of interstitial cell-stimulating hormone are also looked into.

Recent Progress in Hormone Research, Volume 41 covers the proceedings of a Laurentian Hormone Conference held in late August 1984 at the Homestead in Hot Springs, Virginia. The book presents papers on the hormone-receptor interactions; the biosynthesis, secretion, metabolism, and mechanism of action of the steroid hormones; and the mechanisms of action of thyroid-stimulating hormone (TSH) and TRH. The text also includes papers on the molecular characterization of a brain specific mRNA; and the factors affecting changes in frequency and amplitude of GnRH pulses and the resulting functional consequences in various mammals including humans with disorders of fertility. Papers on the biological heritage of mammalian endocrinology, such as the actions of urotensin I in mammals and fishes; and the clinical implications of the glycosylation and posttranslational processing of the TSH are also encompassed. Endocrinologists, neuroscientists, biochemists, biophysicists, and scientists involved in hormone research will find the book invaluable.

Recent Progress in Hormone Research, Volume 35 presents the proceedings of the 1978 Laurentian Hormone Conference held from August 27 through September 1, 1978 at the Mont Tremblant Lodge, Mont Tremblant, Quebec, Canada. The book discusses the organization, structure, transcription, and regulation of the ovalbumin gene; vitellogenesis as a versatile model for hormonal regulation of gene expression; and thyroid hormone receptors and responses. The text also describes the circular dichroism of pituitary hormones; receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex; and estrogen and antiestrogen action in reproductive tissues and tumors. The effects of FSH on gonadal functions; the hormonal control of ovarian follicular development; and studies on atherogenesis and corneal transplantation using cultured vascular and corneal endothelia are also considered. The book further tackles the testis-organizing H-Y antigen and the primary sex-determining mechanism of mammals; the studies of the 3T3-L1 adipocyte-like cell line; and the hormonal interactions in the regulation of blood glucose. Endocrinologists, physiologists, gynecologists, and cell biologists will find the text invaluable.

Recent Progress in Hormone Research, Volume 27 covers the proceedings of the 1970 Laurentian Hormone Conference held in Mont Tremblant, Quebec, Canada on August 29-September 4, 1970. The book discusses the x-ray analysis and the structure of insulin; spontaneous hyperglycemia and/or obesity in laboratory rodents; and the biological properties of the growth hormone-like factor from the plerocercoid of Spirometra mansonoides. The text also describes studies on human chorionic gonadotropin; studies on the structure of thyrotropin and its relationship to luteinizing hormone; and ultimobranchial follicles in the thyroid glands of rats and mice. The use of antibodies for characterization of gonadotropins and steroids; the biosynthesis of pregnenolone; and the metabolism and protein binding of sex steroids in target organs are also considered. The book further tackles the regulation of gene expression in Escherichia coli by cyclic AMP; the mechanism of action of ACTH; and the role of vitamin D and its relationship to parathyroid hormone and calcitonin. The text then encompasses the production and secretion of testicular steroids; the factors affecting the secretion of steroids from the transplanted ovary in the sheep; and the pilot gland approach to the study of insulin secretory dynamics. The analysis of the response to ACTH by rat adrenal in a flowing system is also looked into. Biochemists, physiologists, pathologists, endocrinologists, people working in laboratories of cancer research, chemical crystallography, and molecular biophysics will find the book invaluable.

Recent Progress in Hormone Research: Volume IV is a collection of papers delivered at the 1948 Laurentian Hormone Conference held at Franconia, New Hampshire. This volume is composed of four parts encompassing 16 chapters that cover experimental works on the role of hormones in metabolism and the thyroid physiology and function. The opening part deals with some aspects of steroid hormone metabolism, including progesterone, estrogen, and androgen. This part emphasizes the clinical aspects of physiology and function of ovarian hormones. The subsequent part is devoted to the role of hormones in tissue and body metabolism. This part particularly describes the antihormone problem in endocrine therapy and the alterations in metabolism incident to administration of insulin, adrenalin, and thyroid substances. The metabolic changes under adrenal and pituitary hormone administration are also examined. These topics are followed by discussions on the neurohumoral-hypothalamic relationships, specifically the adrenal function in mental disease and effects of hypothalamic lesions on water and energy metabolism. The final part covers the conditions influencing the production and release of thyroid stimulating hormone by the anterior pituitary; the primary actions of the hormone on its target gland; a possible mode of action; and the factors that influence this hormone's action on the thyroid. This book will prove useful to endocrinologists.