Chronic kidney disease (CKD) is a global health burden with associated high economic costs to the health system. Main factors are the increasing number of patients with diabetes and hypertension and the aging of the population. CKD has been associated with increased risks of cardiovascular morbidity, premature mortality, and/or decreased quality of life. In this new volume, renowned Japanese scientists present their recent research results. Papers cover various aspects of kidney diseases such as cystic kidney diseases, treatment of lupus nephritis, renal anemia and iron metabolism, cell sheet engineering, frailty and outcomes of dialysis patients, and the socioeconomics of rituximab in nephrotic syndrome. Due to the wide range of topics presented, this book will be of interest to readers from various clinical and research settings connected with the care of CKD patients.

Known worldwide, chronic kidney disease (CKD) is a disease that affects up to 4% of the population with increasing figures also in the developing countries. Life expectancy of patients affected by CKD is shortened compared to the overall population, and only a minority of patients reach end-stage renal disease (ESRD) with the need for dialysis or renal transplantation; death overtakes dialysis. In the 13 chapters, this book sheds light on the different aspects related to pathophysiology and clinical aspects of CKD, providing interesting insights into not only inflammation and cardiovascular risk but also the interplay of hormones and the functional aspects of endothelial function. In addition, chapters dealing with genetic aspects of polycystic kidney disease and also the clinical handling of patients with CKD and peritoneal dialysis will be beneficial for the open-minded reader.

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Chinese, Asian and global perspectives Chronic kidney disease is a global major health issue that ultimately leads to end-stage renal disease, a devastating condition requiring costly renal replacement therapy. Given this background, extensive understanding of the pathogenesis of the disease and exploring novel therapeutic targets will help to alleviate disease progression, improve prognosis and reduce its impact on the global economic burden. Currently, primary glomerulonephritis is the leading cause of chronic kidney disease and end-stage renal disease in China and many other countries. Recently, there has been much progress with regard to pathogenesis as well as treatment of primary glomerulonephritis. Clinical data from Chinese studies have significantly contributed to the making of international guidelines and histological classifications of the disease. This book focuses on the cutting-edge knowledge and provides up-to-date information on primary glomerulonephritis. Topics covered are IgA nephropathy, focal segmental glomerulosclerosis, membranous nephropathy, membranoproliferative glomerulonephritis, and crescentic glomerulonephritis.

IgA nephropathy is the most common primary glomerulonephritis in developed countries. The primary defect lies in the abnormalities of the IgA molecule. The disease affects all ages, mainly in the young adults, and may recur in a transplanted kidney.This outstanding volume provides a comprehensive overview of the advances in this disease over the last ten years. It covers the genetics, epidemiology, clinicopathological features, pathogenesis, prognostic mechanisms, and treatment of this unique disease. Twenty-seven chapters are written by 43 experts from 13 countries; these experts have been providing forefront scientific findings to the scientific community for the last 20 years. The book covers all clinical, pathological and molecular aspects of IgA nephropathy. This is an essential source of reference for nephrologists, internists, pathologists, and molecular biologists. It is also suitable reading for graduate students or research scientists in the field of kidney diseases.

In recent decades, we have enhanced our understanding of the pathophysiology and genetics of rare and common causes of kidney stones. With our evolving understanding of the epidemiology, biology, and genetics of nephrolithiasis and the advances in therapeutic technologies, we have made significant progress in patient care. Furthermore, advances in the medical management and surgical technologies have allowed us to embellish the optimal outcomes in the management of complex kidney stone disease.

This companion to Brenner and Rector's The Kidney offers a state-of-the-art summary of the most recent advances in renal genetics. Molecular and Genetic Basis for Renal Disease provides the nephrologist with a comprehensive look at modern investigative tools in nephrology research today, and reviews the molecular pathophysiology of the nephron as well as the most common genetic and acquired renal diseases. A comprehensive clinical review of Medelian renal disease is also be included. Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders.

Based on careful analysis of burden of disease and the costs ofinterventions, this second edition of 'Disease Control Priorities in Developing Countries, 2nd edition' highlights achievable priorities; measures progresstoward providing efficient, equitable care; promotes cost-effectiveinterventions to targeted populations; and encourages integrated effortsto optimize health. Nearly 500 experts - scientists, epidemiologists, health economists,academicians, and public health practitioners - from around the worldcontributed to the data sources and methodologies, and identifiedchallenges and priorities, resulting in this integrated, comprehensivereference volume on the state of health in developing countries.

Acute renal failure is undoubtedly one of the marize in one volume the recent advances on patho most interesting and frequent syndromes observed physiology of acute renal failure, the clinical aspects by clinicians. A great number of factors may of the various forms (even those which have been acutely impair renal function, but the pathoge disregarded in other surveys), the diagnostic tests netic mechanism by which this occurs is fre available today in our clinical practice, the general quently unknown. Even the pathophysiology of and specific therapeutic measures and (very impor ischaemic!toxic forms of acute renal failure re tant, indeed), some useful suggestions for preven mains controversial despite the huge number of tion. experimental and clinical studies. The contributors have provided clear, complete Medical management of patients with acute renal and up-to-date chapters. I am deeply grateful to failure has greatly improved in recent years, partic them all. ularly with the use of different types of dialytic I like to express my sincere thanks to Dr. A.J.