The legend of the Holy Grail is far from unknown, but this is the first time the quest has been given the punk rock treatment. "Rat Scabies and the Holy Grail" is a psychedelic, Pythonesque road trip, a testimony to the sometimes odd nature of friendship, and a rich historical yarn.

The legend of the Holy Grail is far from unknown, but this is the first time the quest has been given the punk rock treatment.

Christopher Dawes lives in a quiet English village. His neighbor is Rat Scabies, former drummer with the Damned, best noted for setting his drums on fire while still playing them at a live concert. Life with Rat as a neighbor isn't run-of-the-mill, but things turn even stranger when Rat announces that he (and Christopher) are going on a search for the Holy Grail. The saga begins in Rennes-le-Chateau in France, where in 1891 a local priest discovered a treasure whose mystery remains unsolved. Once Christopher and Rat have written a list of things to do ("Buy metal detectors!"), they need only unravel a tale involving the Cathars, the Knights Templar, the Man in the Iron Mask, and Louis XIV—and along the way, visit Paris, Rome, Glastonbury, and Tintagel—and perhaps join the Masons (Rat thinks they know something). The legend of the Holy Grail is far from unknown, but this is the first time the quest has been given the punk rock treatment. Rat Scabies and the Holy Grail is a psychedelic, Pythonesque road trip, a testimony to the sometimes odd nature of friendship, and a rich historical yarn.

Therapeutic breakthroughs in medicine are usually accompanied by a wealth of data. Often they result in a change of disease treatment paradigms. Tacrolimus ointment is the first in the new class of steroid-free Topical Immunomodulators (TIMs), and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of T-cell mediated inflammatory skin diseases such as atopic dermatitis. This book gives an easy-to-read overview of the discovery and the development of Tacrolimus ointment for the treatment of atopic dermatitis. Summarising the largest clinical trial program ever conducted in dermatology for a new treatment with more than 13000 patients, it offers a detailed insight into the efficacy and safety profile of Tacrolimus ointment. Based on this large body of data and extensive personal experience, the authors offer practical and hands-on guidance for the physician as to when and how to use Tacrolimus ointment in daily practice.

The follow-up to the bestseller The Holy Blood and The Holy Grail

Are you a witless cretin with no reason to live? Would you like to know more about every piece of knowledge ever? Do you have cash? Then congratulations, because just in time for the death of the print industry as we know it comes the final book ever published, and the only one you will ever need: The Onion's compendium of all things known. Replete with an astonishing assemblage of facts, illustrations, maps, charts, threats, blood, and additional fees to edify even the most simple-minded book-buyer, The Onion Book of Known Knowledge is packed with valuable information -- such as the life stages of an Aunt; places to kill one's self in Utica, New York; and the dimensions of a female bucket, or "pail." With hundreds of entries for all 27 letters of the alphabet, The Onion Book of Known Knowledge must be purchased immediately to avoid the sting of eternal ignorance.

A “thought-provoking and powerful” study that reframes everything you’ve been taught about addiction and recovery—from the New York Times–bestselling author of The Myth of Normal (Bruce Perry, author of The Boy Who Was Raised as a Dog). A world-renowned trauma expert combines real-life stories with cutting-edge research to offer a holistic approach to understanding addiction—its origins, its place in society, and the importance of self-compassion in recovery. Based on Gabor Maté’s two decades of experience as a medical doctor and his groundbreaking work with people with addiction on Vancouver’s skid row, this #1 international bestseller radically re-envisions a much misunderstood condition by taking a compassionate approach to substance abuse and addiction recovery. In the same vein as Bessel van der Kolk’s The Body Keeps the Score, In the Realm of Hungry Ghosts traces the root causes of addiction to childhood trauma and examines the pervasiveness of addiction in society. Dr. Maté presents addiction not as a discrete phenomenon confined to an unfortunate or weak-willed few, but as a continuum that runs throughout—and perhaps underpins—our society. It is not a medical “condition” distinct from the lives it affects but rather the result of a complex interplay among personal history, emotional and neurological development, brain chemistry, and the drugs and behaviors of addiction. Simplifying a wide array of brain and addiction research findings from around the globe, the book avoids glib self-help remedies, instead promoting a thorough and compassionate self-understanding as the first key to healing and wellness. Dr. Maté argues persuasively against contemporary health, social, and criminal justice policies toward addiction and how they perpetuate the War on Drugs. The mix of personal stories—including the author’s candid discussion of his own “high-status” addictive tendencies—and science with positive solutions makes the book equally useful for lay readers and professionals.

Adolescent endometriosis is a previously overlooked disease in children, the true prevalence of which is still unknown but has been estimated between 19-73%. There are numerous initial challenges faced by adolescents suffering from delayed or undiagnosed endometriosis apart from experiencing chronic pain, such as: school/work absenteeism, false diagnoses/treatments, erroneous physician referrals, unnecessary radiological studies, radiation exposure, and emergency room visits as well as early exposure to narcotic pain medications and subsequent drug tolerance, resistance or even addiction. This text presents a clear history of physician and patient understanding and awareness of endometriosis in adolescents. It lays the groundwork for this condition with background information on endometriosis in general followed by a more focused look at endometriosis in adolescents. Leading experts in the field provide chapters on the different locations where endometriotic lesions can present in adolescents as well as identified risk factors and concomitant diseases of which it is important to be aware. In addition to the clinical presentation, this book also provides information on breaking down existing barriers, such as stigma, and current activism and awareness of this condition. Adolescent Endometriosis is a first-of-its-kind text that focuses exclusively on endometriosis in the adolescent population. Written by experts in the field, this book is a comprehensive resource for clinicians in all medical disciplines that treat adolescent age girls.

Autism spectrum disorders (ASD) constitute a major public health problem, affecting one in every 150 children and their families. Unfortunately, there is little understanding of the causes of ASD, and, despite their broad societal impact, many people believe that the overall research program for autism is incomplete, particularly as it relates to the role of environmental factors. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders, in response to a request from the U.S. Secretary of Health and Human Services, hosted a workshop called "Autism and the Environment: Challenges and Opportunities for Research." The focus was on improving the understanding of the ways in which environmental factors such as chemicals, infectious agents, or physiological or psychological stress can affect the development of the brain. Autism and the Environment documents the concerted effort which brought together the key public and private stakeholders to discuss potential ways to improve the understanding of the ways that environmental factors may affect ASD. The presentations and discussions from the workshop that are described in this book identify a number of promising directions for research on the possible role of different environmental agents in the etiology of autism.

Now in paperback, this first oral history of the most nihilistic of all pop movements brings the sound of the punk generation chillingly to life with 50 new pages of depraved testimony. "Please Kill Me" reads like a fast-paced novel, but the tragedies it contains are all too human and all too real. photos.