Functional imaging of the brain is one of the most rapidly advancing areas of neuroscience and Positron Emission Tomography (PET) plays a major role in this progress. This book provides a comprehensive overview of the current status of PET and state-of-the-art neuroimaging. It is comprised of summaries of the presentations by experts in the field. Topics covered include radiotracer selection, advances in instrumentation, image reconstruction and data analysis, and statistical mapping of brain activity. This book focuses on the accuracy of the functional image and the strategies for addressing clinical, scientific, and diagnostic questions.Covers the PET imaging process from tracer selection to analysis and interpretationContains 79 concise reports with abundant illustrationsThe definitive state-of-the-art book for functional neuroscience with PET

PET and SPECT in Psychiatry showcases the combined expertise of renowned authors whose dedication to the investigation of psychiatric disease through nuclear medicine technology has achieved international recognition. The classical psychiatric disorders as well as other subjects – such as suicide, sleep, eating disorders, and autism – are discussed and the latest results in functional neuroimaging are detailed. Most chapters are written jointly by a clinical psychiatrist and a nuclear medicine expert to ensure a multidisciplinary approach. This state of the art compendium will be valuable to all who have an interest in the field of neuroscience, from the psychiatrist and the radiologist/nuclear medicine specialist to the interested general practitioner and cognitive psychologist. It is the first volume of a trilogy on PET and SPECT imaging in the neurosciences; other volumes will focus on PET and SPECT in neurology and PET and SPECT of neurobiological systems.

Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. - A focused introduction to imaging healthy and diseased brains - Focuses on the primary neurotransmitter release - Includes sigma, acetylcholine, opioid, and dopamine receptors - Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease

Among all the clinical indications for which radiologists, nuclear medicine phy- cians, neurologists, neurosurgeons, psychiatrists (and others examining disorders of the brain) order and read brain PET scans, demand is greatest for those pertaining to dementia and related disorders. This demand is driven by the sheer prevalence of those conditions, coupled with the fact that the differential diagnosis for causes of cognitive impairment is wide and often difficult to distinguish clinically. The conceptual framework by which evaluation and management of dementia is guided has evolved considerably during the last decade. Although we still are far from having ideal tests or dramatic cures for any of the established causes of dementia, our options have expanded with respect to both the diagnostic and the- peutic tools now available. In the first chapter of this book, the contribution and limitations of different elements of the clinical examination for diagnosis of cog- tive symptoms are described, and the roles of structural and functional neuroim- ing in the clinical workup are given context.

Addresses the methodological issues related to the tracer kinetics and image analysis in brain PET. The book should provide non-expert readers with the full methodological scope of brain PET and expert readers with the future direction of PET.

Physiological Imaging of the Brain with PET provides the latest techniques and applications for PET as a tool to study the physiology of the brain, and is sponsored by the International Society of Cerebral Blood Flow and Metabolism. It covers all of the fundamental disciplines of PET in one volume. Written by international experts in brain imaging, it is a useful reference for the active brain PET scientist, and a valuable introduction to students, clinicians, and researchers who wish to take advantage of the capabilities of this technique to study the normal and diseased brain. Key Features * Provides the latest techniques and applications of positron emission tomography (PET) * Covers all fundamental disciplines of PET in one volume * Serves as a comprehensive resource for students, clinicians and new researchers

This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain. - Authored by international authorities in PET - Provides the latest up-to-date techniques and applications - Covers all fundamental disciplines of PET in one volume - A comprehensive resource for students, clinicians, and new PET researchers

Neuroimaging and Neurophysiology in Psychiatry is an invaluable guide through the methods and applications of neuroimaging and neurophysiology.

In an age where the amount of data collected from brain imaging is increasing constantly, it is of critical importance to analyse those data within an accepted framework to ensure proper integration and comparison of the information collected. This book describes the ideas and procedures that underlie the analysis of signals produced by the brain. The aim is to understand how the brain works, in terms of its functional architecture and dynamics. This book provides the background and methodology for the analysis of all types of brain imaging data, from functional magnetic resonance imaging to magnetoencephalography. Critically, Statistical Parametric Mapping provides a widely accepted conceptual framework which allows treatment of all these different modalities. This rests on an understanding of the brain's functional anatomy and the way that measured signals are caused experimentally. The book takes the reader from the basic concepts underlying the analysis of neuroimaging data to cutting edge approaches that would be difficult to find in any other source. Critically, the material is presented in an incremental way so that the reader can understand the precedents for each new development. This book will be particularly useful to neuroscientists engaged in any form of brain mapping; who have to contend with the real-world problems of data analysis and understanding the techniques they are using. It is primarily a scientific treatment and a didactic introduction to the analysis of brain imaging data. It can be used as both a textbook for students and scientists starting to use the techniques, as well as a reference for practicing neuroscientists. The book also serves as a companion to the software packages that have been developed for brain imaging data analysis. - An essential reference and companion for users of the SPM software - Provides a complete description of the concepts and procedures entailed by the analysis of brain images - Offers full didactic treatment of the basic mathematics behind the analysis of brain imaging data - Stands as a compendium of all the advances in neuroimaging data analysis over the past decade - Adopts an easy to understand and incremental approach that takes the reader from basic statistics to state of the art approaches such as Variational Bayes - Structured treatment of data analysis issues that links different modalities and models - Includes a series of appendices and tutorial-style chapters that makes even the most sophisticated approaches accessible

Praise for this book:Sure to be a hit -- just like the first edition...All the chapters are well written and the accuracy of information is impressive...[we] cannot recommend the book strongly enough.--RAD MagazineReturning in a second edition, this practical book presents oncological and nononcological applications for PET and PET/CT for the full range of scenarios frequently encountered in the professional setting. Placing special emphasis on PET/CT correlation and FDG oncological imaging, it opens with a thorough introduction to fundamental science and clinical basics. Each chapter in the Oncological Applications section of the book describes the role of PET and PET/CT in the management of specific diseases, providing succinct descriptions of indications and comparisons with other imaging modalities. Highlights: New chapters covering PET/CT for pediatric patients; the use of FDG PET in the evaluation of infection and inflammation; and the role of PET and PET/CT in radiation therapy planning; and FDG biology More than 500 high-quality images, including state-of-the-art color PET/CT images Pearls and pitfalls that emphasize critical concepts Discussion of normal variations and benign findings Thorough review of the current literature on PET/CT This compact book provides readers with the tools to sharpen their assessment and decision-making skills. Organized efficiently to enable rapid reference to key concepts, this concise text is ideal for residents and practitioners in radiology, nuclear medicine, oncology, radiation oncology, and nuclear medicine technology.