This issue of Medical Clinics, guest edited by Drs. Marc Shalaby and Edward Bollard, is devoted to Quality Patient Care: Making Evidence-Based, High Value Choices. Articles in this issue include: Cardiovascular testing in asymptomatic patients: carotid duplex, cardiac stress testing, screen for PVD; Utility of echocardiogram in the evaluation of heart murmurs; Evidenced-based recommendations for the evaluation of palpitations in the primary care setting; Radiologic evaluation of common orthopedic complaints: low back pain, non-traumatic knee/shoulder/hip pain, and ankle injuries; Indications and usefulness of common injections for non-traumatic orthopedic complaints – shoulder, trochanteric bursa, epidural injections, tennis elbow, and knee; The evidence-based evaluation of chronic cough; Evaluation of uncomplicated headache; Evaluation of syncope; Pre-operative assessment: Cataract surgery, pre-operative EKG testing, screening for cardiopulmonary disease, urinalysis, coagulation studies, other lab assessments; The approach to occult GI bleed; The role of EGD surveillance for patients with Barrett’s esophagus; The evidence-based evaluation of iron deficiency anemia; Cancer screening in the elderly; Utilization and safety of common over the counter dietary/nutritional supplements, herbal agents and homeopathic compounds for disease prevention; Utilization of oxygen for the patient with dyspnea; IV fluids, enteral or parenteral nutrition; and Symptom control at the end of life.

This issue of Medical Clinics, guest edited by Drs. Scott Kahan and Robert Kushner, is devoted to Practice-Based Nutrition Care. Articles in this outstanding issue include: Principles and Practice of Nutrition Assessment in Primary Care; Principles and Practice of Nutrition Counseling and Behavioral Medicine in Primary Care; Nutrition for the Prevention of Chronic Disease; Nutrition Recommendations in Pregnancy and Lactation; Nutrition Recommendations in Children; Nutrition Recommendations in Elderly and Aging; Nutrition Interventions for Cardiovascular Disease; Nutrition Interventions for Renal Disease; Nutrition Interventions for Diabetes Mellitus and Metabolic Syndrome; Nutrition Interventions for Chronic Liver Disease and NAFLD; Nutrition Interventions for Obesity; and Nutrition Interventions for Cancers.

This issue of Medical Clinics of North America, guest edited by Drs. Douglas Paauw and Kim O'Connor, is devoted to Pharmacologic Therapy. Articles in this issue include: Pharmacologic Therapies for Autoimmune and Rheumatologic Conditions; Pharmacologic Therapies for Ophthalmologic Conditions; Pharmacologic Therapies for Neurologic Conditions; Pharmacologic Therapies for Cardiac Conditions; Pharmacologic Therapies in Men’s Health; Pharmacologic Therapies in Anticoagulation; Pharmacologic Therapies in Women’s Health: Menopause Treatment and Contraception; Pharmacologic Therapies in GI disease; Pharmacologic Therapies in Pulmonology and Allergy; Pharmacologic Therapies for Substance Abuse; Pharmacologic Therapies in Infectious Disease; Pharmacologic Therapies for HIV; Pharmacologic Therapies in Type 2 DM; Pharmacologic Therapies in Musculoskeletal Conditions; and Osteoporosis Treatment.

This issue of Medical Clinics, guest edited by Dr. Thomas G. DeLoughery, is devoted to anemia. Articles in this issue include: Anemia: Evaluation and Diagnostic Tests; Anemia of Chronic Disease; B12/Folate Deficiency; Iron Deficiency; Myelodysplasia; Autoimmune Hemolytic Anemia; Congenital Hemolytic Anemia; Sickle Cell Disease; Thrombotic Microangiopathy; Unusual Anemias; and Transfusion Therapy.

This issue of Medical Clinics of North America, guest edited by Paul S. Pottinger and Christopher A. Sanford, is devoted to Travel and Adventure Medicine. Articles in this issue include: Immunizations; Malaria; Personal Protection Measures; Traveler’s Diarrhea; Urban Medicine and Trauma; Care of the Healthcare Provider; Evaluation of the Ill Returned Traveler; The Ethics of Medical Volunteerism; High-Altitude Medicine; Dive Medicine; Wilderness Medicine, Including First Aid & Hypo/Hyperthermia; The Medical Kit; Adventure Sports: Spelunking, water exposures; and Resources for the Provider and Opportunities in Further Training in Travel and Adventure Medicine.

This issue of Medical Clinics, guest edited by Dr. Edward Frohlich, is devoted to Hypertension. Articles in this outstanding issue include The Kidney in Hypertension; Heart: Fibrosis, Apoptosis, and Cardiac Failure; Myocardial Ischemia; Oxidative Stress and Hypertensive Diseases; Adherence to Antihypertensive Therapy; Aging and Hypertension; Target Organs and Microbiological Considerations in Hypertensive Diseases; Obesity and Sodium Considerations; Diabetes, Hypertension and Cardiorenal Syndrome; Renal Arterial Disease; Cardiac Transplantation and Hypertensive Diseases; Cardiac Failure: Old and New Challenges; Diastolic Dysfunction and Hypertension; Stiffening of Large Arteries; Genetics and Mechanisms; New Guidelines for Hypertensive Diseases; and Local Renin Angiotensin Systems.

This issue of Medical Clinics of North America, guest edited by Drs. David A. Sass and Alden M. Doyl, is devoted to Care of the Liver and Kidney Transplant Recipient. Articles in this issue include: Liver and kidney transplantation: a half-century historical perspective; From Child’s-Pugh to MELD: Deciding who really needs a liver transplant; When to consider renal transplantation in your advanced CKD patients; Management of the liver transplant recipient: approach to allograft dysfunction; Acute and chronic allograft dysfunction in renal transplant recipients; The ABC's of Immunosuppression: a primer for the primary care physician; Managing cardiovascular risk in the post solid organ transplant recipient; Diabetes care after transplant: definitions, risk factors, and clinical management; De novo malignancies after transplantation: risk and surveillance strategies; Metabolic bone disease in the post-transplant population: preventative and therapeutic measures; Infectious complications and vaccinations in the post-transplant population; Selection and post-operative care of the living donor; and Long-term functional recovery, quality of life and pregnancy following solid organ transplantation.

This issue of Anesthesiology Clinics focuses on Preoperative Patient Evaluation and is edited by Dr. Zdravka Zafirova and Dr. Richard Urman. Article topics include: Designing and Running a Preoperative Clinic; Preoperative Laboratory Testing; Patients with Cardiac Disease Undergoing Noncardiac Surgery; Preoperative Evaluation and Estimation of Pulmonary Risk; Stratification and Risk Reduction of Perioperative Acute Kidney Injury; Anticoagulants and Hematologic Disorders and Anemia; Nutrition and Prehabilitation; Perioperative Management of Diabetes and Other Endocrine Conditions; Preoperative Management of the Geriatric Patient, including Frailty and Cognitive Impairment Assessment; Management of Challenging Pharmacological Issues, including Chronic Pain and Substance Abuse Disorders; Assessment of the Pregnant Patient; Genomics Testing and Personalized Medicine in the Preoperative Setting; Shared Decision Making; Preoperative Management of Medications; Perioperative Surgical Home Models; and Preoperative Evaluation of the Pediatric Patient.

Evidence base in 2015 remains a subject of controversy for surgeons related to its application in surgery that cannot be approached as it is in medical evidence. Academic surgeons acknowledge that evidence base is necessary and private practitioners know it is woven into the fabric of their practice. Dr. Lisa Ishii and Dr. Travis Tollefson, editors of this publication, are at the forefront of clinical use of and research into evidence based surgery. The Oxford Centre system of evidence is used for this issue. Currently, evidence is dominant in the reconstructive aspect, moreso than the cosmetic aspect; as such, this resource focuses on the nerve and microvascular procedures. Topics include Facial vascular anomalies, Cleft lip and palate; Trauma; Facial reanimation; System reviews and metanalyses; and Skin care, Laser treatments; and Rhinoplasty. Audience for this resource is facial plastic surgeons, otolaryngologists, plastic surgeons, laser therapists, dermatologists, and skin researchers.

This issue of Neurosurgery Clinics, edited by Alejandro A. Rabinstein, will focus on Neurocritical Care. Topics will include Anoxic-Ischemic Brain Injury, Practical Approach to Posttraumatic Intracranial Hypertension According to Pathophysiologic Reasoning, Management of Traumatic Brain Injury: An Update, Cortical Spreading Depression and Ischemia in Neurocritical Patients, Targeted Temperature Management in Brain-Injured Patients, Herpes Virus Encephalitis in Adults: Current Knowledge and Old Myths, Primary Acute Neuromuscular Respiratory Failure, Intensive Care Unit–Acquired Weakness, Recent Advances in the Acute Management of Intracerebral Hemorrhage, New Developments in Refractory Status Epilepticus, Acute Cardiac Complications in Critical Brain Disease, Nosocomial Infections in the Neurointensive Care Unit, Neurologic Complications of Solid Organ Transplantation, and Shared Decision Making in Neurocritical Care.