This new, revised and updated edition takes into account the most recent advances in the understanding of human pathophysiology. The book presents the complex basic principles of vascular hemodynamics and its pathophysiologie in a direct and effective way, stressing the importance of the mechanical properties of large arteries in the origin of blood pressure. The readily understandable text, supported by helpful images, describes the elements that define blood pressure and explains such important concepts as pulse wave velocity, central blood pressure, reflected waves, and pulse pressure amplification. Entirely new chapters are included on the sympathetic nervous system and arterial stiffness and on the role played by arterial stiffness in influencing blood pressure variability. The book will enable the physician to answer some of the key questions encountered when addressing the problem of arterial hypertension in everyday clinical practice: How is blood pressure generated? How should blood pressure values be interpreted? Is systolic blood pressure of greater importance than diastolic blood pressure?

This new, revised and updated edition takes into account the most recent advances in the understanding of human pathophysiology. The book presents the complex basic principles of vascular hemodynamics and its pathophysiologie in a direct and effective way, stressing the importance of the mechanical properties of large arteries in the origin of blood pressure. The readily understandable text, supported by helpful images, describes the elements that define blood pressure and explains such important concepts as pulse wave velocity, central blood pressure, reflected waves, and pulse pressure amplification. Entirely new chapters are included on the sympathetic nervous system and arterial stiffness and on the role played by arterial stiffness in influencing blood pressure variability. The book will enable the physician to answer some of the key questions encountered when addressing the problem of arterial hypertension in everyday clinical practice: How is blood pressure generated? How should blood pressure values be interpreted? Is systolic blood pressure of greater importance than diastolic blood pressure?

Early Vascular Aging (EVA): New Directions in Cardiovascular Protection, Second Edition continues to be the most comprehensive and authoritative resource on premature alterations in artery structure and function. The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. This second edition contains completely updated content with expanded coverage of basic and translational research, systematic reviews of the most prominent literature, discussion of applicability of new evidence and more. Written by an international team of clinicians and researchers, this is a valuable resource to basic and translational scientists, clinical researchers and clinicians in the cardiovascular field interested in prevention, diagnosis and treatment of EVA. - Contains all the relevant information available on the main paradigm shifts in vascular aging research, from different fields of knowledge (from basic biology to epidemiology) - Reviews the most prominent evidence produced on early vascular aging (EVA), highlighting recent research advances, clinical applications, and research opportunities - Formulates, in each chapter, a set of research questions that need to be addressed, challenging the vast research community to take on new directions and collaborations

Recently, several studies have shown the crucial role of viscoelastic properties of the aorta and large arteries in determining blood pressure values. A good knowledge of cardiovascular pathophysiology and vascular hemodynamics is necessary to understand these phenomena. However, available texts on this topic are very complex and difficult for medical practitioners to understand. The aim of this book is to enable the reader to comprehend the relation between cardiovascular pathophysiology and vascular hemodynamics and to become familiar with the more recent guidelines. While very complex physical concepts are involved, care has been taken to ensure that the explanations are as straightforward as possible. Complex analyses are presented separately and can be skipped by the reader without impairment of understanding. It is envisaged that the knowledge imparted will prove invaluable in improving the approach to hypertensive patients.

One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.

APlusPhysics: Your Guide to Regents Physics Essentials is a clear and concise roadmap to the entire New York State Regents Physics curriculum, preparing students for success in their high school physics class as well as review for high marks on the Regents Physics Exam. Topics covered include pre-requisite math and trigonometry; kinematics; forces; Newton's Laws of Motion, circular motion and gravity; impulse and momentum; work, energy, and power; electrostatics; electric circuits; magnetism; waves; optics; and modern physics. Featuring more than five hundred questions from past Regents exams with worked out solutions and detailed illustrations, this book is integrated with the APlusPhysics.com website, which includes online question and answer forums, videos, animations, and supplemental problems to help you master Regents Physics essentials. "The best physics books are the ones kids will actually read." Advance Praise for APlusPhysics Regents Physics Essentials: "Very well written... simple, clear engaging and accessible. You hit a grand slam with this review book." -- Anthony, NY Regents Physics Teacher. "Does a great job giving students what they need to know. The value provided is amazing." -- Tom, NY Regents Physics Teacher. "This was tremendous preparation for my physics test. I love the detailed problem solutions." -- Jenny, NY Regents Physics Student. "Regents Physics Essentials has all the information you could ever need and is much easier to understand than many other textbooks... it is an excellent review tool and is truly written for students." -- Cat, NY Regents Physics Student

Humans receive the vast majority of sensory perception through the eyes and ears. This non-technical book examines the everyday physics behind hearing and vision to help readers understand more about themselves and their physical environment. It begins wit

MICHEL E. SAFAR and MICHAEL F. O'ROURKE One of the principal problems of hypertension is the precise definition of blood pressure as a cardiovascular risk factor. Clinicians indicate peak systolic pressure and end diastolic pressure in the brachial artery as the principal criteria for blood pressure measurement. Consequently, these values are as indicators for clinical management and therapeutic adjustment. This used methodology, based on indirect blood pressure measurements at the site of the brachial artery relates only to the highest and lowest pressure in that vessel, and does not give any information of the blood pressure curve itself; this carries more information than peak systolic pressure and end diastolic pressure. As a first step in better analysis of the blood pressure curve, research workers in experimental hypertension defined in addition to peak systolic pressure and end diastolic, another blood pressure value, mean arterial pressure, i. e. the average pressure throughout the cardiac cycle, and about which pressure fluctuates. This is the pressure recorded by Hales [1] and by Poiseuille [2] in their pioneering studies. By application of Poiseuille's Law, this definition of mean arterial pressure led to the concept that increased mean arterial pressure (and therefore hypertension) was related, at any given value of cardiac output, to an increase in vascular resistance, i. e. to a reduc tion in the caliber of the small arteries.

This book is the first comprehensive overview of the emerging field of cuffless blood pressure monitoring. Increasing clinical evidence proves that longitudinal measurements of blood pressure allow for earlier detection and better management of multiple medical conditions and for superior prediction of cardiovascular events. Unfortunately, today’s clinical and industry standards for blood pressure monitoring still require the inflation of a pneumatic cuff around a limb each time a measurement is taken. Over the last decades clinicians, scientists and device manufacturers have explored the feasibility of technologies that reduce or even completely eliminate the need of cuffs, initiating the era of cuffless blood pressure monitoring. Among the existing literature, this book is intended to be a practical guide to navigate across this emerging field. The chapters of the handbook have been elaborated by experts and key opinion leaders in the domain, and will guide the reader along the clinical, scientific, technical, and regulatory aspects of cuffless blood pressure monitoring.