Proteolytic Signaling In Health And Disease
Download Proteolytic Signaling In Health And Disease full books in PDF, epub, and Kindle. Read online free Proteolytic Signaling In Health And Disease ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads.
Author |
: Andre Zelanis |
Publisher |
: Academic Press |
Total Pages |
: 308 |
Release |
: 2021-10-13 |
ISBN-10 |
: 9780323856973 |
ISBN-13 |
: 0323856977 |
Rating |
: 4/5 (73 Downloads) |
Synopsis Proteolytic Signaling in Health and Disease by : Andre Zelanis
In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called ‘protease web’, and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events. Examines biological events triggered by proteolytic enzyme activity across human development and pathologies Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types Features methods and protocols supporting further study of proteolytic signaling events Includes chapter contributions from international leaders in the field
Author |
: Sajal Chakraborti |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 407 |
Release |
: 2013-12-04 |
ISBN-10 |
: 9781461492337 |
ISBN-13 |
: 1461492335 |
Rating |
: 4/5 (37 Downloads) |
Synopsis Proteases in Health and Disease by : Sajal Chakraborti
In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.
Author |
: |
Publisher |
: |
Total Pages |
: 0 |
Release |
: 2002 |
ISBN-10 |
: 0815332181 |
ISBN-13 |
: 9780815332183 |
Rating |
: 4/5 (81 Downloads) |
Synopsis Molecular Biology of the Cell by :
Author |
: Michele Reboud-Ravaux |
Publisher |
: Springer |
Total Pages |
: 0 |
Release |
: 2012-11-05 |
ISBN-10 |
: 3642627145 |
ISBN-13 |
: 9783642627149 |
Rating |
: 4/5 (45 Downloads) |
Synopsis Protein Degradation in Health and Disease by : Michele Reboud-Ravaux
Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.
Author |
: Wolfgang B. Liedtke, MD, PH.D. |
Publisher |
: CRC Press |
Total Pages |
: 502 |
Release |
: 2006-09-29 |
ISBN-10 |
: 9781420005844 |
ISBN-13 |
: 1420005847 |
Rating |
: 4/5 (44 Downloads) |
Synopsis TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by : Wolfgang B. Liedtke, MD, PH.D.
Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st
Author |
: S.H. Fatemi |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 473 |
Release |
: 2008-06-04 |
ISBN-10 |
: 9780387767611 |
ISBN-13 |
: 0387767614 |
Rating |
: 4/5 (11 Downloads) |
Synopsis Reelin Glycoprotein by : S.H. Fatemi
Reelin glycoprotein is a serine protease with important roles in embryogenesis and during adult life. This comprehensive and integrative book examines the role that reelin plays in the etiology of various neuropsychiatric disorders, including schizophrenia and autism. The book provides an unprecedented analysis of this emerging and novel protein by examining evidence from genetic, neuroanatomic, biochemical, and behavioral studies.
Author |
: Enrico Di Cera |
Publisher |
: Academic Press |
Total Pages |
: 335 |
Release |
: 2011-03-07 |
ISBN-10 |
: 9780123855053 |
ISBN-13 |
: 0123855055 |
Rating |
: 4/5 (53 Downloads) |
Synopsis Proteases in Health and Disease by : Enrico Di Cera
Proteases occur naturally in all organisms. They are enzymes that are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments. - Discusses new discoveries, approaches, and ideas - Contributions from leading scholars and industry experts - Reference guide for researchers involved in molecular biology and related fields
Author |
: Klaudia Brix |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 568 |
Release |
: 2014-01-21 |
ISBN-10 |
: 9783709108857 |
ISBN-13 |
: 3709108853 |
Rating |
: 4/5 (57 Downloads) |
Synopsis Proteases: Structure and Function by : Klaudia Brix
Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic agents is extremely promising. Approaching proteolysis as the most important, irreversible post-translational protein modification essentially requires an integrated effort of complementary research disciplines. In fact, proteolytic enzymes seem as diverse as the scientists working with these intriguing proteins. This book reflects the efforts of many in this exciting field of research where team and network formations are essential to move ahead.
Author |
: Niels Behrendt |
Publisher |
: John Wiley & Sons |
Total Pages |
: 419 |
Release |
: 2012-07-10 |
ISBN-10 |
: 9783527329915 |
ISBN-13 |
: 3527329919 |
Rating |
: 4/5 (15 Downloads) |
Synopsis Matrix Proteases in Health and Disease by : Niels Behrendt
Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition. With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.
Author |
: Mercedes Diaz-Mendoza |
Publisher |
: Frontiers Media SA |
Total Pages |
: 157 |
Release |
: 2020-01-24 |
ISBN-10 |
: 9782889633999 |
ISBN-13 |
: 2889633993 |
Rating |
: 4/5 (99 Downloads) |
Synopsis Plant Proteases by : Mercedes Diaz-Mendoza
Plant proteases are involved in most aspects of plant physiology and development, playing key roles in the generation of signaling molecules and as regulators of essential cellular processes such as cell division and metabolism. They take part in important pathways like protein turnover by the degradation of misfolded proteins and the ubiquitin-proteasome pathway, and they are responsible for post-translational modifications of proteins by proteolysis at highly specific sites. Proteases are also implicated in a great variety of environmentally controlled processes, including mobilization of storage proteins during seed germination, development of seedlings, senescence, programmed cell death and defense mechanisms against pests and pathogens. However, in spite of their importance, little is known about the functions and mode of actions of specific plant proteases. This Research Topic collects contributions covering diverse aspects of plant proteases research.