Protein Conformational Dynamics
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Author |
: Ke-li Han |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 488 |
Release |
: 2014-01-20 |
ISBN-10 |
: 9783319029702 |
ISBN-13 |
: 3319029703 |
Rating |
: 4/5 (02 Downloads) |
Synopsis Protein Conformational Dynamics by : Ke-li Han
This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events.
Author |
: Ferruccio Palazzesi |
Publisher |
: |
Total Pages |
: |
Release |
: 2015 |
ISBN-10 |
: OCLC:935751619 |
ISBN-13 |
: |
Rating |
: 4/5 (19 Downloads) |
Synopsis Protein Conformational Dynamics: a Computational Study by : Ferruccio Palazzesi
Author |
: Dennis R. Livesay |
Publisher |
: Humana |
Total Pages |
: 0 |
Release |
: 2016-08-23 |
ISBN-10 |
: 1493963074 |
ISBN-13 |
: 9781493963072 |
Rating |
: 4/5 (74 Downloads) |
Synopsis Protein Dynamics by : Dennis R. Livesay
In Protein Dynamics: Methods and Protocols, expert researchers in the field detail both experimental and computational methods to interrogate molecular level fluctuations. Chapters detail best-practice recipes covering both experimental and computational techniques, reflecting modern protein research. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Dynamics: Methods and Protocols describes the most common and powerful methods used to characterize protein dynamics.
Author |
: Rahul Banerjee |
Publisher |
: |
Total Pages |
: 217 |
Release |
: 2014 |
ISBN-10 |
: 1321153163 |
ISBN-13 |
: 9781321153163 |
Rating |
: 4/5 (63 Downloads) |
Synopsis Protein Conformational Dynamics in a Two-component Signal Transduction System by : Rahul Banerjee
Author |
: Jeffrey Alan Hanson |
Publisher |
: |
Total Pages |
: 488 |
Release |
: 2009 |
ISBN-10 |
: UCAL:C3519051 |
ISBN-13 |
: |
Rating |
: 4/5 (51 Downloads) |
Synopsis Bridging the Gap Between Protein Structure and Dynamics by : Jeffrey Alan Hanson
Author |
: Robert M. Culik |
Publisher |
: |
Total Pages |
: 183 |
Release |
: 2014 |
ISBN-10 |
: OCLC:890960546 |
ISBN-13 |
: |
Rating |
: 4/5 (46 Downloads) |
Synopsis Infrared Measurements of Protein Conformational Dynamics by : Robert M. Culik
Author |
: |
Publisher |
: Elsevier |
Total Pages |
: 368 |
Release |
: 2013-08-14 |
ISBN-10 |
: 9780124116276 |
ISBN-13 |
: 0124116272 |
Rating |
: 4/5 (76 Downloads) |
Synopsis Dynamics of Proteins and Nucleic Acids by :
Published continuously since 1944, Advances in Protein Chemistry and Structural Biology has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. - Covers reviews of methodology and research in all aspects of protein chemistry - Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics
Author |
: Robel Birru Yirdaw |
Publisher |
: |
Total Pages |
: 151 |
Release |
: 2012 |
ISBN-10 |
: OCLC:798817471 |
ISBN-13 |
: |
Rating |
: 4/5 (71 Downloads) |
Synopsis Conformational Dynamics of Proteins by Fluorescence Fluctuation Spectroscopy by : Robel Birru Yirdaw
Author |
: Derek J. Chadwick |
Publisher |
: John Wiley & Sons |
Total Pages |
: 282 |
Release |
: 2008-04-30 |
ISBN-10 |
: 9780470514153 |
ISBN-13 |
: 0470514159 |
Rating |
: 4/5 (53 Downloads) |
Synopsis Protein Conformation by : Derek J. Chadwick
How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the protein folding problem and various aspects for future progress.
Author |
: Rory Sleno |
Publisher |
: |
Total Pages |
: |
Release |
: 2017 |
ISBN-10 |
: OCLC:1013747727 |
ISBN-13 |
: |
Rating |
: 4/5 (27 Downloads) |
Synopsis Shedding a New Light on Protein Conformational Dynamics by : Rory Sleno
"As key effector units of the cell, understanding structure and function relationships of proteins are integral to explaining physiology and, in turn, pathophysiology. With the cost of drug development soaring and success dwindling, new ways to probe protein function will be at the forefront of innovation. A protein's function is the product of its conformational dynamics, where distinct 3-dimensional conformations of a protein dictate its various effects on the cell. Though highly valuable technologies capable of reporting on protein conformation currently exist, X-ray crystallography and nuclear magnetic resonance among others, their capacity to report on dynamic events and/or in physiologically relevant assay conditions are limited.This thesis describes the development and application of biosensors capable of reporting on protein conformation in live human cells. Biosensors were developed for two classes of protein targets, ion channels - Kir3, and G protein-coupled receptors (GPCR) - FP and AT1R, together representing the targets of a majority of current prescription drugs. The biosensor design was based on bioluminescence resonance energy transfer (BRET) and required the insertion of a bioluminescent protein and a short peptide sequences within the protein of interest. Due to the specific affinity for the peptide sequence of an organic fluorophore, fluorescein biarsenical hairpin binder (FlAsH), the latter could be used as a resonance energy transfer acceptor to probe the different conformations of the protein of interest without disrupting its function.Both panels of biosensors successfully reported on ligand-induced conformational rearrangements in the target proteins and correlated with functional effects. The GPCR biosensors were further applied to enrich our understanding of receptor dimerization and allosteric communication between proteins, in this case, the FP/AT1R heterodimer." --