This book describes the epidemiological and evolutionary consequences of the use of genetically modified (GM) mosquitoes as well as research orientations and ethical issues concerning the use of GM mosquitoes. It also includes discussion on transgenic mosquitoes for malaria control.

**The instant New York Times bestseller.** *An international bestseller.* Finalist for the Lane Anderson Award Finalist for the RBC Taylor Award “Hugely impressive, a major work.”—NPR A pioneering and groundbreaking work of narrative nonfiction that offers a dramatic new perspective on the history of humankind, showing how through millennia, the mosquito has been the single most powerful force in determining humanity’s fate Why was gin and tonic the cocktail of choice for British colonists in India and Africa? What does Starbucks have to thank for its global domination? What has protected the lives of popes for millennia? Why did Scotland surrender its sovereignty to England? What was George Washington's secret weapon during the American Revolution? The answer to all these questions, and many more, is the mosquito. Across our planet since the dawn of humankind, this nefarious pest, roughly the size and weight of a grape seed, has been at the frontlines of history as the grim reaper, the harvester of human populations, and the ultimate agent of historical change. As the mosquito transformed the landscapes of civilization, humans were unwittingly required to respond to its piercing impact and universal projection of power. The mosquito has determined the fates of empires and nations, razed and crippled economies, and decided the outcome of pivotal wars, killing nearly half of humanity along the way. She (only females bite) has dispatched an estimated 52 billion people from a total of 108 billion throughout our relatively brief existence. As the greatest purveyor of extermination we have ever known, she has played a greater role in shaping our human story than any other living thing with which we share our global village. Imagine for a moment a world without deadly mosquitoes, or any mosquitoes, for that matter? Our history and the world we know, or think we know, would be completely unrecognizable. Driven by surprising insights and fast-paced storytelling, The Mosquito is the extraordinary untold story of the mosquito’s reign through human history and her indelible impact on our modern world order.

Thoroughly reviews our current understanding of malarial biology Explores the subject with insights from post-genomic technologies Looks broadly at the disease, vectors of infection, and treatment and prevention strategies A timely publication with chapters written by global researchers leaders

Progress in Mosquito Research provides readers with the latest interdisciplinary reviews on the topic. It is an essential reference source for invertebrate physiologists, neurobiologists, entomologists, zoologists, and insect chemists, with Volume 51 focusing on recent progress in mosquito research. - Presents a comprehensive overview of recent progress in mosquito science - Written by leaders in their respective areas of mosquito research - Ideal resource for invertebrate physiologists, neurobiologists, entomologists, zoologists, and insect chemists

Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. - Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission - Provides a summary of the concepts of both population suppression and population replacement - Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

The “King of Sting” describes his adventures with insects and the pain scale that’s made him a scientific celebrity. Silver, Science (Adult Non-Fiction) Foreword INDIES Award 2017 Entomologist Justin O. Schmidt is on a mission. Some say it’s a brave exploration, others shake their heads in disbelief. His goal? To compare the impacts of stinging insects on humans, mainly using himself as the test case. In The Sting of the Wild, the colorful Dr. Schmidt takes us on a journey inside the lives of stinging insects. He explains how and why they attack and reveals the powerful punch they can deliver with a small venom gland and a “sting,” the name for the apparatus that delivers the venom. We learn which insects are the worst to encounter and why some are barely worth considering. The Sting of the Wild includes the complete Schmidt Sting Pain Index, published here for the first time. In addition to a numerical ranking of the agony of each of the eighty-three stings he’s sampled so far, Schmidt describes them in prose worthy of a professional wine critic: “Looks deceive. Rich and full-bodied in appearance, but flavorless” and “Pure, intense, brilliant pain. Like walking over flaming charcoal with a three-inch nail embedded in your heel.” Schmidt explains that, for some insects, stinging is used for hunting: small wasps, for example, can paralyze huge caterpillars for long enough to lay eggs inside them, so that their larvae emerge within a living feast. Others are used to kill competing insects, even members of their own species. Humans usually experience stings as defensive maneuvers used by insects to protect their nest mates. With colorful descriptions of each venom’s sensation and a story that leaves you tingling with awe, The Sting of the Wild’s one-of-a-kind style will fire your imagination.

Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.

This publication is intended to contribute to prevention and control of the morbidity and mortality associated with dengue and to serve as an authoritative reference source for health workers and researchers. These guidelines are not intended to replace national guidelines but to assist in the development of national or regional guidelines. They are expected to remain valid for five years (until 2014), although developments in research could change their validity.--Publisher's description.

Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.