The searing, wry memoir about a woman's fight for a new life after a devastating brain injury. When Sarah Vallance is thrown from a horse and suffers a jarring blow to the head, she believes she's walked away unscathed. The next morning, things take a sharp turn as she's led from work to the emergency room. By the end of the week, a neurologist delivers a devastating prognosis: Sarah suffered a traumatic brain injury that has caused her IQ to plummet, with no hope of recovery. Her brain has irrevocably changed. Afraid of judgment and deemed no longer fit for work, Sarah isolates herself from the outside world. She spends months at home, with her dogs as her only source of companionship, battling a personality she no longer recognizes and her shock and rage over losing simple functions she'd taken for granted. Her life is consumed by fear and shame until a chance encounter gives Sarah hope that her brain can heal. That conversation lights a small flame of determination, and Sarah begins to push back, painstakingly reteaching herself to read and write, and eventually reentering the workforce and a new, if unpredictable, life. In this highly intimate account of devastation and renewal, Sarah pulls back the curtain on life with traumatic brain injury, an affliction where the wounds are invisible and the lasting effects are often misunderstood. Over years of frustrating setbacks and uncertain triumphs, Sarah comes to terms with her disability and finds love with a woman who helps her embrace a new, accepting sense of self.

"What is going to happen to me?" Most patients ask this question during a clinical encounter with a health professional. As well as learning what problem they have (diagnosis) and what needs to be done about it (treatment), patients want to know about their future health and wellbeing (prognosis). Prognosis research can provide answers to this question and satisfy the need for individuals to understand the possible outcomes of their condition, with and without treatment. Central to modern medical practise, the topic of prognosis is the basis of decision making in healthcare and policy development. It translates basic and clinical science into practical care for patients and populations. Prognosis Research in Healthcare: Concepts, Methods and Impact provides a comprehensive overview of the field of prognosis and prognosis research and gives a global perspective on how prognosis research and prognostic information can improve the outcomes of healthcare. It details how to design, carry out, analyse and report prognosis studies, and how prognostic information can be the basis for tailored, personalised healthcare. In particular, the book discusses how information about the characteristics of people, their health, and environment can be used to predict an individual's future health. Prognosis Research in Healthcare: Concepts, Methods and Impact, addresses all types of prognosis research and provides a practical step-by-step guide to undertaking and interpreting prognosis research studies, ideal for medical students, health researchers, healthcare professionals and methodologists, as well as for guideline and policy makers in healthcare wishing to learn more about the field of prognosis.

This groundbreaking book explains prognosis from the perspective of doctors, examining why physicians are reluctant to predict the future, how doctors use prognosis, the symbolism it contains, and the emotional difficulties it involves. Drawing on his experiences as a doctor and sociologist, Nicholas Christakis interviewed scores of physicians and searched dozens of medical textbooks and medical school curricula for discussions of prognosis in an attempt to get to the core of this nebulous medical issue that, despite its importance, is only partially understood and rarely discussed. "Highly recommended for everyone from patients wrestling with their personal prognosis to any medical practitioner touched by this bioethical dilemma."—Library Journal, starred review "[T]he first full general discussion of prognosis ever written. . . . [A] manifesto for a form of prognosis that's equal parts prediction-an assessment of likely outcomes based on statistical averages-and prophecy, an intuition of what lies ahead."—Jeff Sharlet, Chicago Reader "[S]ophisticated, extraordinarily well supported, and compelling. . . . [Christakis] argues forcefully that the profession must take responsibility for the current widespread avoidance of prognosis and change the present culture. This prophet is one whose advice we would do well to heed."—James Tulsky, M.D., New England Journal of Medicine

This book serves as a clinical guide to help the practitioner improve endodontic treatment outcomes. It focuses on the various factors affecting the prognosis of endodontic treatments and on their impact on short-term and long-term results. The text incorporates up-to-date knowledge, techniques and treatment protocols. Each chapter has been carefully chosen to address either foundational knowledge or a select aspect of endodontic treatment. The authors analyze the knowledge accumulated from a large number of outcome studies and provide the reader with a critical appraisal indicating the strengths and weaknesses of those studies. This information is then used to make recommendations on how to predict the outcome of the intended treatment. The authors emphasize that the endodontic prognosis is a multifactorial phenomenon, underscoring how various factors, singularly and in combination, influence the treatment outcome. Readers are provided with tools to successfully assess the prognosis of the proposed treatment at the outset and to execute the planned treatment focused on optimal outcome.

Jim Moore’s poems “are chips of reality, obsidian flakes of the heart and mind” (Jane Hirshfield) In his eighth collection, the celebrated poet Jim Moore looks into unrelenting darkness where moments of tenderness and awe illuminate, at times suddenly like lightning in the night, at others, more quietly, as the steady glow of streetlights in a snowstorm. These are poems of both patience and urgency, of necessary attendance and helpless exuberance in the breathing world—something rare in contemporary poetry. Written in Minneapolis amid the COVID-19 pandemic’s masked and distanced loneliness, after the police murder of George Floyd, as an empire comes to an end, Prognosis turns toward the living moment as a surprising source of abundance. Here we find instances of essential human connection animated by a saving grace that pulls us back from depression and despair. Contemplating with playful wisdom what it is to brave the later years of one’s life, Moore revels in the possibilities of joy and mourns the limits of our capacity to greet the unknown with resolve and wonder. The prognosis Moore foresees demands continued stillness, continued movement: “Also known as going home,” he writes. “Also known as getting over yourself.”

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

This book describes how Cold War researchers used expert opinions to construct foreknowledge of geopolitical relevance. Focusing on the RAND Corporation, an American think tank with close relations to the armed forces, Dayé analyses the development of two techniques of prognosis, the Delphi technique and Political Gaming. Based on archival research and interviews, the chapters explore the history of this series of experiments to understand how contemporary social scientists conceived of one of the core categories of the Cold War, the expert, and uncover the systematic use of expert opinions to craft prognoses. This consideration of the expert’s role in Cold War society and what that can tell us about the role of the expert today will be of interest to students and scholars across the history of science, the sociology of knowledge, future studies, the history of the Cold War, social science methodology, and social policy.

This book presents the work of the RILEM Technical Committee 259-ISR. Addressing two complementary but fundamental issues: the kinetics of the reaction, and how this will affect the integrity of the structure (serviceability and strength), it also provides methodology for assessing past deterioration to enable readers to make engineering/science-based predictions concerning future expansion. The book is divided into six major topics: selection and interpretation of optimal monitoring system for structures undergoing expansion to monitor the progress of the swelling evolution and its consequences; development/refinement of current laboratory procedures to determine the kinetics of the reaction i.e. expansion vs (future) time, and to determine the kinetic characteristics of the time-dependent reaction to be used in a finite element simulation; extrapolation of results from structural component laboratory testing; selection of material properties based on data from existing structures affected by the alkali silica reaction or delayed ettringite formation; identification of critical features that should be present in a finite element code, development of test problems for validation, and a survey of relevant programs able to conduct a transient structural analysis of a structure undergoing chemically induced expansion; and lastly guidelines for finite element codes. The book is intended for practitioners responsible for concrete structures affected by the damaging alkali aggregate reaction, engineers dealing with aging structures, and researchers in the field.