This volume contains a selection of papers presented at the Second Seattle Symposium in Biostatistics: Analysis of Correlated Data. The symposium was held in 2000 to celebrate the 30th anniversary of the University of Washington School of Public Health and Community Medicine. It featured keynote lectures by Norman Breslow, David Cox and Ross Prentice and 16 invited presentations by other prominent researchers. The papers contained in this volume encompass recent methodological advances in several important areas, such as longitudinal data, multivariate failure time data and genetic data, as well as innovative applications of the existing theory and methods. This volume is a valuable reference for researchers and practitioners in the field of correlated data analysis.

A state of the art volume on statistical causality Causality: Statistical Perspectives and Applications presents a wide-ranging collection of seminal contributions by renowned experts in the field, providing a thorough treatment of all aspects of statistical causality. It covers the various formalisms in current use, methods for applying them to specific problems, and the special requirements of a range of examples from medicine, biology and economics to political science. This book: Provides a clear account and comparison of formal languages, concepts and models for statistical causality. Addresses examples from medicine, biology, economics and political science to aid the reader's understanding. Is authored by leading experts in their field. Is written in an accessible style. Postgraduates, professional statisticians and researchers in academia and industry will benefit from this book.

Space, structure, and randomness: these are the three key concepts underlying Georges Matheron’s scientific work. He first encountered them at the beginning of his career when working as a mining engineer, and then they resurfaced in fields ranging from meteorology to microscopy. What could these radically different types of applications possibly have in common? First, in each one only a single realisation of the phenomenon is available for study, but its features repeat themselves in space; second, the sampling pattern is rarely regular, and finally there are problems of change of scale. This volume is divided in three sections on random sets, geostatistics and mathematical morphology. They reflect his professional interests and his search for underlying unity. Some readers may be surprised to find theoretical chapters mixed with applied ones. We have done this deliberately. GM always considered that the distinction between the theory and practice was purely academic. When GM tackled practical problems, he used his skill as a physicist to extract the salient features and to select variables which could be measured meaningfully and whose values could be estimated from the available data. Then he used his outstanding ability as a mathematician to solve the problems neatly and efficiently. It was his capacity to combine a physicist’s intuition with a mathematician’s analytical skills that allowed him to produce new and innovative solutions to difficult problems. The book should appeal to graduate students and researchers working in mathematics, probability, statistics, physics, spatial data analysis, and image analysis. In addition it will be of interest to those who enjoy discovering links between scientific disciplines that seem unrelated at first glance. In writing the book the contributors have tried to put GM’s ideas into perspective. During his working life, GM was a genuinely creative scientist. He developed innovative concepts whose usefulness goes far beyond the confines of the discipline for which they were originally designed. This is why his work remains as pertinent today as it was when it was first written.

This book offers a new, fairly efficient, and robust alternative to analyzing multivariate data. The analysis of data based on multivariate spatial signs and ranks proceeds very much as does a traditional multivariate analysis relying on the assumption of multivariate normality; the regular L2 norm is just replaced by different L1 norms, observation vectors are replaced by spatial signs and ranks, and so on. A unified methodology starting with the simple one-sample multivariate location problem and proceeding to the general multivariate multiple linear regression case is presented. Companion estimates and tests for scatter matrices are considered as well. The R package MNM is available for computation of the procedures. This monograph provides an up-to-date overview of the theory of multivariate nonparametric methods based on spatial signs and ranks. The classical book by Puri and Sen (1971) uses marginal signs and ranks and different type of L1 norm. The book may serve as a textbook and a general reference for the latest developments in the area. Readers are assumed to have a good knowledge of basic statistical theory as well as matrix theory. Hannu Oja is an academy professor and a professor in biometry in the University of Tampere. He has authored and coauthored numerous research articles in multivariate nonparametrical and robust methods as well as in biostatistics.

Random Effect and Latent Variable Model Selection In recent years, there has been a dramatic increase in the collection of multivariate and correlated data in a wide variety of ?elds. For example, it is now standard pr- tice to routinely collect many response variables on each individual in a study. The different variables may correspond to repeated measurements over time, to a battery of surrogates for one or more latent traits, or to multiple types of outcomes having an unknown dependence structure. Hierarchical models that incorporate subje- speci?c parameters are one of the most widely-used tools for analyzing multivariate and correlated data. Such subject-speci?c parameters are commonly referred to as random effects, latent variables or frailties. There are two modeling frameworks that have been particularly widely used as hierarchical generalizations of linear regression models. The ?rst is the linear mixed effects model (Laird and Ware , 1982) and the second is the structural equation model (Bollen , 1989). Linear mixed effects (LME) models extend linear regr- sion to incorporate two components, with the ?rst corresponding to ?xed effects describing the impact of predictors on the mean and the second to random effects characterizing the impact on the covariance. LMEs have also been increasingly used for function estimation. In implementing LME analyses, model selection problems are unavoidable. For example, there may be interest in comparing models with and without a predictor in the ?xed and/or random effects component.

The application and interpretation of statistics are central to ecological study and practice. Ecologists are now asking more sophisticated questions than in the past. These new questions, together with the continued growth of computing power and the availability of new software, have created a new generation of statistical techniques. These have resulted in major recent developments in both our understanding and practice of ecological statistics. This novel book synthesizes a number of these changes, addressing key approaches and issues that tend to be overlooked in other books such as missing/censored data, correlation structure of data, heterogeneous data, and complex causal relationships. These issues characterize a large proportion of ecological data, but most ecologists' training in traditional statistics simply does not provide them with adequate preparation to handle the associated challenges. Uniquely, Ecological Statistics highlights the underlying links among many statistical approaches that attempt to tackle these issues. In particular, it gives readers an introduction to approaches to inference, likelihoods, generalized linear (mixed) models, spatially or phylogenetically-structured data, and data synthesis, with a strong emphasis on conceptual understanding and subsequent application to data analysis. Written by a team of practicing ecologists, mathematical explanations have been kept to the minimum necessary. This user-friendly textbook will be suitable for graduate students, researchers, and practitioners in the fields of ecology, evolution, environmental studies, and computational biology who are interested in updating their statistical tool kits. A companion web site provides example data sets and commented code in the R language.

This account of recent works on weakly dependent, long memory and multifractal processes introduces new dependence measures for studying complex stochastic systems and includes other topics such as the dependence structure of max-stable processes.

Population growth and global health disparities for many reproductive and perinatal outcomes are but a few of the pressing issues facing public health today. Despite growing interest in the field, formal training in reproductive and perinatal epidemiology remains limited, with few available textbooks aimed at providing an overview of the field. In response to this need, faculty from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) and CIHR's Institute of Human Development, Child and Youth Health (IHDCYH) developed an intensive, competitive, Summer Institute in Reproductive and Perinatal Epidemiology. The curriculum of this Summer Institute has been developed into a textbook to provide students and researchers with a working knowledge of the substantive and methodologic issues underlying reproductive and perinatal epidemiology. Reproductive and Perinatal Epidemiology offers a core curriculum that addresses the epidemiology of major reproductive and perinatal outcomes. From human fecundity to birth and neonatal outcomes, the subject is approached from as international a perspective as possible, and the unique methodologic issues underlying each outcome are discussed. Developed by leading researchers in collaboration with their students in response to their needs and concerns, this is the definitive textbook on the subject.