Preserving the Promise: Improving the Culture of Biotech Investment critically examines why most biotech startups fail, as they emerge from universities into an ecosystem that inhibits rather than encourages innovation. This "Valley of Death" squanders our public investments in medical research and with them, the promise of longer and healthier lives. The authors explicate the Translation Gap faced by early stage biotech companies, the result of problematic technology transfer and investment practices, and provide specific prescriptions for improving translation of important discoveries into safe and effective therapies. In Preserving the Promise, Dessain and Fishman build on their collective experience as company founders, healthcare investor (Fishman) and physician/scientist (Dessain). The book offers a forward-looking, critical analysis of "conventional wisdom" that encumbers commercialization practices. It exposes the self-defeating habits of drug development in the Valley of Death, that waste money and extinguish innovative technologies through distorted financial incentives. - Explains why translation of biotech discovery into medicine succeeds so infrequently that it's been dubbed the Valley of Death - Uncovers specific decision-making strategies that more effectively align incentives, improving clinical and financial outcomes for investors, inventor/entrepreneurs, and patients - Examines the critical, early stages of commercialization, where technology transfer offices and Angels act as gatekeepers to development, and where tension between short-term financial and long-term clinical aspirations sinks important technologies - Deconstructs the forces driving biotech, recasts them in a proven conceptual framework, and offers practical guidance for making the system better

Entertaining, fast-paced, instructional, The Change Maker is not only a memoir, but a blueprint for how we can change our own lives, as well as the world around us, by providing personal lessons in the values of strategic thinking and responsible leadership. Through compelling true stories, both humorous and serious, Al Checchi demonstrates that through experience, vision, and courage, one person can make a difference and lead others to move beyond their comfort zones and transform our institutions. Al Checchi, a remarkable change maker, chronicles how his creativity, strategic thinking, and negotiating skills helped transform three major American institutions—Marriott Corporation, Walt Disney, and Northwest Airlines—and led him to challenge the California political establishment as a candidate for governor. Peppered with excerpts from speeches and articles, The Change Maker offers thoughtful perspective on institutional change in America since the 1960s, and scalding commentary on the current state of our public and private institutions, political parties, the emergent political class, and the economic policies and leadership of today’s administration. The Change Maker challenges us to confront the status quo and demand accountability and a restoration of the fiduciary standards that are so vital to reclaiming and maintaining America's position of economic and political leadership. Readers will finish the book feeling revitalized, hopeful, and armed with new ideas on how change can, and always will, occur.

Translation of: Conserves naturelles des quatre saisons.

Spreading democracy abroad or protecting business at home: this book offers a new look at the history of the contest between isolationalism and internationalism that is as current as the wars in Iraq and Afghanistan and as old as America itself, with profiles of the people, policies, and events that shaped the debate.

An expanded edition of the powerful memoir about two sisters' determination to survive during the Holocaust featuring new and never before revealed information about the first transport of women to Auschwitz In March 1942, Rena Kornreich and 997 other young women were rounded up and forced onto the first Jewish transport of women to Auschwitz. Soon after, Rena was reunited with her sister Danka at the camp, beginning a story of love and courage that would last three years and forty-one days. From smuggling bread for their friends to narrowly escaping the ever-present threats that loomed at every turn, the compelling events in Rena’s Promise remind us that humanity and hope can survive inordinate brutality.

Some of our attitudes are fitting, others unfitting. It seems fitting to admire Mandela, but not Idi Amin, and to believe that the Seine flows through Paris, but not that the Thames does. Fitting attitudes get things right. Conor McHugh and Jonathan Way argue that fittingness is the key to understanding the normative domain--the domain of reasons, obligations, and value. They develop and defend a novel 'fittingness first' approach, on which fittingness is a normatively basic property and all other normative properties depend on fittingness. They show how this approach illuminates central questions in ethics and epistemology.

This essay collection draws upon work presented at three national conferences on women and historic preservation held at Bryn Mawr College in 1994, Arizona State University in 1997, and at Mount Vernon College in 2000.

Oxford Studies in Metaethics is the only publication devoted exclusively to original philosophical work in the foundations of ethics. It provides an annual selection of much of the best new scholarship being done in the field. Its broad purview includes work being done at the intersections of ethical theory with metaphysics, epistemology, philosophy of language, and philosophy of mind. The essays included in the series provide an excellent basis for understanding recent developments in the field; those who would like to acquaint themselves with the current state of play in metaethics would do well to start here.

In The Promise of the Foreign, Vicente L. Rafael argues that translation was key to the emergence of Filipino nationalism in the nineteenth century. Acts of translation entailed technics from which issued the promise of nationhood. Such a promise consisted of revising the heterogeneous and violent origins of the nation by mediating one’s encounter with things foreign while preserving their strangeness. Rafael examines the workings of the foreign in the Filipinos’ fascination with Castilian, the language of the Spanish colonizers. In Castilian, Filipino nationalists saw the possibility of arriving at a lingua franca with which to overcome linguistic, regional, and class differences. Yet they were also keenly aware of the social limits and political hazards of this linguistic fantasy. Through close readings of nationalist newspapers and novels, the vernacular theater, and accounts of the 1896 anticolonial revolution, Rafael traces the deep ambivalence with which elite nationalists and lower-class Filipinos alike regarded Castilian. The widespread belief in the potency of Castilian meant that colonial subjects came in contact with a recurring foreignness within their own language and society. Rafael shows how they sought to tap into this uncanny power, seeing in it both the promise of nationhood and a menace to its realization. Tracing the genesis of this promise and the ramifications of its betrayal, Rafael sheds light on the paradox of nationhood arising from the possibilities and risks of translation. By repeatedly opening borders to the arrival of something other and new, translation compels the nation to host foreign presences to which it invariably finds itself held hostage. While this condition is perhaps common to other nations, Rafael shows how its unfolding in the Philippine colony would come to be claimed by Filipinos, as would the names of the dead and their ghostly emanations.