This book presents worked examples of five analytical procedures. These practical examples address traceability, validation and measurement uncertainty aspects in a systematic and consistent way, and cover applications in the analysis of water, food, as well as ores and minerals. This concept is based on the experiences of the TrainMiCc program, in which more than 9000 laboratory professionals all over Europe have participated.

"Case studies on traceability, measurement uncertainty and validation for measurements of gold in gold alloys, calcium in serum, radium in water, polar pesticides in food and ammonium in water are presented in this report. Additionally, the idea and structure of the TrainMiC examples, which complement the TrainMiC theoretical presentations, are described in detail to give a complete overview of the TrainMIC teaching material."--Editor.

Quantification, Validation and Uncertainty in Analytical Sciences Companion guide explaining all processes in measuring uncertainty in quantitative analytical results Quantification, Validation and Uncertainty in Analytical Sciences provides basic and expert knowledge by building on the sequence of operations starting from the quantification in analytical sciences by defining the analyte and linking it to the calibration function. Proposing a comprehensive approach to MU (Measurement Uncertainty) estimation, it empowers the reader to apply Method Accuracy Profile (MAP) efficiently as a statistical tool in measuring uncertainty. The text elucidates several examples and template worksheets explaining the theoretical aspects of the procedure and includes novel method validation procedures that can accurately estimate the data obtained in measurements. It also enables the reader to provide practical insights to improve decision making by accurately evaluating and comparing different analytical methods. Brings together an interdisciplinary approach with statistical tools and algorithms applied in analytical chemistry and written by two international experts with long-standing experience in the field of Analytical measurements and Uncertainty, Quantification, Validation and Uncertainty in Analytical Sciences includes information on: The know-how of methods in an analytical laboratory, effective usage of a spurious measurement and methods to estimate errors. Quantification, calibration, precision, trueness, MAP addons, estimating MU for analytical sciences, and uncertainty functions Employing measurement uncertainty, sampling uncertainty, quantification limits, and sample conformity assessment Decision making, uncertainty and standard addition method, and accuracy profile for method comparison Quantification, Validation and Uncertainty in Analytical Sciences is an ideal resource for every individual quantifying or studying analytes. With several chapters dedicated to MU’s practical use in decision making demonstrating its advantages, the book is primarily intended for professional analysts, although researchers and students will also find it of interest.

This monograph contains a survey on the role of chirality in ecotoxicological processes. The focus is on environmental trace analysis. Areas such as toxicology, ecotoxicology, synthetic chemistry, biology, and physics are also covered in detail in order to explain the different properties of enantiomers in environmental samples. This monograph delivers a comprehensive survey for environmental trace analysts, analytical chemists, ecotoxicologists, food scientists and experienced lab workers.

In the history of humankind, the sea has always played a key role as a privileged medium for communication, commerce and contact among population centers. It constitutes an essential ecosystem, and an invaluable reservoir and source of food for all living beings. Therefore, its heath is a critical challenge for the survival of all humanity, particularly as one the most important environmental components targeted by global warming. Measuring and monitoring techniques are key tools for managing the marine environment and for supporting the Blue Economy. With this perspective, a series of annual international events, entitled Metrology for the Sea (MetroSea for short) was begun in 2017. Their increasing success inspired this book, which provides an anthology of tutorials dealing with a representative selection of topics of concern to a broad readership. The book covers two broad application areas, marine hydrography and meteorology, and then deals with instrumentation for measurement at sea. Typical metrological issues such as calibration and traceability, are considered, for both physical and chemical quantities. Key techniques, such as underwater acoustic investigation, remote sensing, measurement of waves and monitoring networks, are treated alongside marine geology and the monitoring of animal species. Economic and legal aspects of metrology for navigation are also discussed. Such an unparalleled wide vision of measurement for the sea will be of interest to a broad audience of scientists, engineers, economists, and their students.

Driving innovation can reduce costs for companies, institutions, military programs, and successful businesses. Quality is key to successful innovation. Delivery of complex products must have high quality to reduce customer problems and defects. This book explains how to integrate Quality Assurance processes to produce compliant product management and gap analysis. It shows how Quality Assurance provides a common operating framework in which best practices, improvements, and cost avoidance activities can be shared. Effective Processes for Quality Assurance emphasizes improving process execution and reducing operational costs. It also focuses on how Quality Assurance personnel must support companies, institutions, military programs, and successful businesses by encouraging a cooperative, proactive approach and ensure compliance through management and team member participation. Lean and Agile can provide a competitive advantage, and this practical reference explains how to implement these two principles to deliver products that have fewer defects. It also explains: Quality Assurance methods Measuring benefits of Quality Assurance process improvement Quality Assurance performance and improvement Risk management Quality Assurance improvement with metrics Effective processes for Quality Assurance Quantitative process performance and commitments Quality Assurance plans Quality Assurance for customers and suppliers Supporting software configuration Effective Processes for Quality Assurance covers the critical issues for implementing Quality Assurance processes that can deliver high-quality products successfully.

This book is designed to assist industrial engineers and production managers in developing procedural and methodological engineering tools to meet industrial standards and mitigate engineering and production challenges. It offers practitioners expert guidance on how to implement adequate statistical process control (SPC), which takes account of the capability to ensure a stable process and then regulate if variations take place due to variables other than a random variation. Powerful engineering models of new product introduction (NPI), continuous improvement (CI), and the eight disciplines (8D) model of problem solving techniques are explained. The final three chapters introduce new methodological models in operations research (OR) and their applications in engineering, including the hyper-hybrid coordination for process effectiveness and production efficiency, and the Kraljic-Tesfay portfolio matrix of industrial buying.

With its coverage of Food and Drug Administration regulations, international regulations, good manufacturing practices, and process analytical technology, this handbook offers complete coverage of the regulations and quality control issues that govern pharmaceutical manufacturing. In addition, the book discusses quality assurance and validation, drug stability, and contamination control, all key aspects of pharmaceutical manufacturing that are heavily influenced by regulatory guidelines. The team of expert authors offer you advice based on their own firsthand experience in all phases of pharmaceutical manufacturing.

This book offers a new physical chemistry perspective on the control of lipid oxidation reactions by antioxidants, and it further explores the application of several oxidation inhibition strategies on food and biological systems. Divided in 3 parts, the book reviews the latest methods to control lipid oxidation, it examines lipid oxidation and inhibition in different food systems, and it finishes with an overview of the biological, health and nutritional effects of lipid oxidation. Chapters from expert contributors cover topics such as the use of magnetic methods to monitor lipid and protein oxidation, the kinetics and mechanisms of lipid oxidation and antioxidant inhibition reactions, interfacial chemistry, oxidative stress and its impact in human health, nutritional, sensory and physiological aspects of lipid oxidation, and new applications of plant and marine antioxidants. While focused on lipid peroxidation in food and biological systems, the chemistry elucidated in this book is applicable also to toxicology, medicine, plant physiology and pathology, and cosmetic industry. The book will therefore appeal to researchers in the lipid oxidation field covering food, biological and medical areas.