The emergence of systems biology raises many fascinating questions: What does it mean to take a systems approach to problems in biology? To what extent is the use of mathematical and computational modelling changing the life sciences? How does the availability of big data influence research practices? What are the major challenges for biomedical research in the years to come? This book addresses such questions of relevance not only to philosophers and biologists but also to readers interested in the broader implications of systems biology for science and society. The book features reflections and original work by experts from across the disciplines including systems biologists, philosophers, and interdisciplinary scholars investigating the social and educational aspects of systems biology. In response to the same set of questions, the experts develop and defend their personal perspectives on the distinctive character of systems biology and the challenges that lie ahead. Readers are invited to engage with different views on the questions addressed, and may explore numerous themes relating to the philosophy of systems biology. This edited work will appeal to scholars and all levels, from undergraduates to researchers, and to those interested in a variety of scholarly approaches such as systems biology, mathematical and computational modelling, cell and molecular biology, genomics, systems theory, and of course, philosophy of biology.

Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry. Studying the philosophical foundations of systems biology may resolve a longer standing issue, i.e., the extent to which Biology is entitled to its own scientific foundations rather than being dominated by existing philosophies.* Answers the question of what distinguishes the living from the non-living* An in-depth look to a vigorous and expanding discipline, from molecule to system* Explores the region between individual components and the system

A survey of how engineering techniques from control and systems theory can be used to help biologists understand the behavior of cellular systems.

An essential introduction to the philosophy of biology This is a concise, comprehensive, and accessible introduction to the philosophy of biology written by a leading authority on the subject. Geared to philosophers, biologists, and students of both, the book provides sophisticated and innovative coverage of the central topics and many of the latest developments in the field. Emphasizing connections between biological theories and other areas of philosophy, and carefully explaining both philosophical and biological terms, Peter Godfrey-Smith discusses the relation between philosophy and science; examines the role of laws, mechanistic explanation, and idealized models in biological theories; describes evolution by natural selection; and assesses attempts to extend Darwin's mechanism to explain changes in ideas, culture, and other phenomena. Further topics include functions and teleology, individuality and organisms, species, the tree of life, and human nature. The book closes with detailed, cutting-edge treatments of the evolution of cooperation, of information in biology, and of the role of communication in living systems at all scales. Authoritative and up-to-date, this is an essential guide for anyone interested in the important philosophical issues raised by the biological sciences.

Since Darwin, Biology has been framed on the idea of evolution by natural selection, which has profoundly influenced the scientific and philosophical comprehension of biological phenomena and of our place in Nature. This book argues that contemporary biology should progress towards and revolve around an even more fundamental idea, that of autonomy. Biological autonomy describes living organisms as organised systems, which are able to self-produce and self-maintain as integrated entities, to establish their own goals and norms, and to promote the conditions of their existence through their interactions with the environment. Topics covered in this book include organisation and biological emergence, organisms, agency, levels of autonomy, cognition, and a look at the historical dimension of autonomy. The current development of scientific investigations on autonomous organisation calls for a theoretical and philosophical analysis. This can contribute to the elaboration of an original understanding of life - including human life - on Earth, opening new perspectives and enabling fecund interactions with other existing theories and approaches. This book takes up the challenge.

This book brings together for the first time philosophers of biology to write about some of the most central concepts and issues in their field from the perspective of biology education. The chapters of the book cover a variety of topics ranging from traditional ones, such as biological explanation, biology and religion or biology and ethics, to contemporary ones, such as genomics, systems biology or evolutionary developmental biology. Each of the 30 chapters covers the respective philosophical literature in detail and makes specific suggestions for biology education. The aim of this book is to inform biology educators, undergraduate and graduate students in biology and related fields, students in teacher training programs, and curriculum developers about the current state of discussion on the major topics in the philosophy of biology and its implications for teaching biology. In addition, the book can be valuable to philosophers of biology as an introductory text in undergraduate and graduate courses.

The philosophy of biology is one of the most exciting new areas in the field of philosophy and one that is attracting much attention from working scientists. This Companion, edited by two of the founders of the field, includes newly commissioned essays by senior scholars and up-and-coming younger scholars who collectively examine the main areas of the subject - the nature of evolutionary theory, classification, teleology and function, ecology, and the problematic relationship between biology and religion, among other topics. Up-to-date and comprehensive in its coverage, this unique volume will be of interest not only to professional philosophers but also to students in the humanities and researchers in the life sciences and related areas of inquiry.

Bioinformatics for Systems Biology bridges and unifies many disciplines. It presents the life scientist, computational biologist, and mathematician with a common framework. Only by linking the groups together may the true life sciences revolution move forward.

The domain of nonlinear dynamical systems and its mathematical underpinnings has been developing exponentially for a century, the last 35 years seeing an outpouring of new ideas and applications and a concomitant confluence with ideas of complex systems and their applications from irreversible thermodynamics. A few examples are in meteorology, ecological dynamics, and social and economic dynamics. These new ideas have profound implications for our understanding and practice in domains involving complexity, predictability and determinism, equilibrium, control, planning, individuality, responsibility and so on.Our intention is to draw together in this volume, we believe for the first time, a comprehensive picture of the manifold philosophically interesting impacts of recent developments in understanding nonlinear systems and the unique aspects of their complexity. The book will focus specifically on the philosophical concepts, principles, judgments and problems distinctly raised by work in the domain of complex nonlinear dynamical systems, especially in recent years.-Comprehensive coverage of all main theories in the philosophy of Complex Systems -Clearly written expositions of fundamental ideas and concepts -Definitive discussions by leading researchers in the field -Summaries of leading-edge research in related fields are also included