The pharmacodynamics and pharmacokinetics of several drugs is expected to be known to clinicians and researchers at all times. With advances in sciences and development of newer drugs very frequently, it is very important to keep your knowledge updated at all times. This title is a quick guide to researchers and clinicians for a quick reference. The title is also a vital resource for all streams of neurosciences (neuroanesthesia and neurointensive care) and is much different from a conventional pharmacology titles, being more reader friendly and to the point facilitated with numerous flowcharts and algorithms with each chapter being prepared in a standard structured manner.

Market: Pharmacy and medical students; neuroscientists; neurologists; pharmacologists Updated edition has an attractive full-color design with more illustrations Includes numerous Fact Boxes to help reinforce learning

Stimulant drugs are widely used in the treatment of ADHD in children and adults. Hundreds of studies over the past 60 years have demonstrated their effectiveness in improving attention span, increasing impulse control, and reducing hyperactivity and restlessness. Despite widespread interest in these compounds, however, their mechanisms of action in the central nervous system have remained poorly understood. Recent advances in the basic and clinical neurosciences now afford the possibility of elucidating these mechanisms. The current volume is the first to bring this expanding knowledge to bear on the central question of why and how stimulants exert their therapeutic effects. The result is a careful, comprehensive, and insightful integration of material by well-known scientists that significantly advances our understanding of stimulant effects and charts a course for future research. Part I presents a comprehensive description of the clinical features of ADHD and the clinical response to stimulants. Part II details the cortical and subcortical neuroanatomy and functional neurophysiology of dopamine and norepinephrine systems with respect to the regulation of attention, arousal, activity, and impulse control and the effects of stimulants on these systems. Part III is devoted to clinical research, including recent studies of neuroimaging, genetics, pharmacodynamic and pharmacokinetic properties of stimulants, effects on cognitive functions, neurophysiological effects in humans with and without ADHD and in non-human primates, and comparison of stimulants and non-stimulants in the treatment of ADHD. Part IV is a masterful synthesis that presents alternative models of stimulant drug action and generates key hypotheses for continued research. The volume will be of keen interest to researchers and clinicians in psychiatry, psychology, and neurology, neuroscientists studying stimulants, and those pursuing development of new drugs to treat ADHD.

In recent years there has been much interest in clinical pharmacology and its ap plication to the treatment of disease, including disease of the nervous system. At the same time there have been major advances in basic neuropharmacology. The aim of this book is to integrate clinical pharmacology with basic neuropharmacology and clinical neurology. The book discusses, in the light of clinical pharmacology, and par ticularly pharmacokinetics, the treatment of those disorders of the nervous system that are conventionally managed by the clinical neurologist. Matters pertaining to psychopharmacology have been deliberately excluded except in so far as they impinge on ordinary clinical neurological practice. The extent to which various disorders have been considered has depended partly on their importance to the clinical neurologist practising in non-tropical areas, and partly on the amount of data available relating to the relevant drug treatment. Thus the book is directed at clinical neurologists and those intending to practise clinical neurology. However it also contains material of in terest to the general physician, paediatrician, psychiatrist and clinical pharmacologist. Although the emphasis in this book is on drug treatment, to preserve balance it has seemed desirable to discuss briefly certain non-pharmacological aspects of thera peutics. The orderly methodical approach used in the book offers two possible advan tages: first, once the reader is familiar with the approach (see Guide to the Use of This Book, p.

This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

Drug addiction is a chronically relapsing mental illness involving severe motivational disturbances and loss of behavioral control leading to personal dev- tation. The disorder af?icts millions of people, often co-occurring with other mental illnesses with enormous social and economic costs to society. Several decades of research have established that drugs of abuse hijack the brain’s natural reward substrates, and that chronic drug use causes aberrant alterations in these rewa- processing systems. Such aberrations may be demonstrated at the cellular, neu- transmitter, and regional levels of information processing using either animal models or neuroimaging in humans following chronic drug exposure. Behaviorally, these neural aberrations manifest as exaggerated, altered or dysfunctional expr- sion of learned behavioral responses related to the pursuit of drug rewards, or to environmental factors that precipitate craving and relapse during periods of drug withdrawal. Current research efforts are aimed at understanding the associative and causal relationships between these neurobiological and behavioral events, such that treatment options will ultimately employ therapeutic amelioration of neural de?cits and restoration of normal brain processing to promote efforts to abstain from further drug use. The Behavioral Neuroscience of Drug Addiction, part of the Springer series on Current Topics in Behavioral Neurosciences, contains scholarly reviews by noted experts on multiple topics from both basic and clinical neuroscience ?elds.

The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond.

This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. This popular primer provides a solid understanding of the nervous system, neurologic disorders, and treatments with drugs and other substances Nestler, Hyman, and Malenka’s Molecular Neuropharmacology, Fourth Edition covers everything you need to know about molecular neuroscience. This meticulously detailed guide provides a deep dive into the pathophysiology of neurologic and psychiatric disorders by describing neuropharmacological fundamentals of the nervous system. Packed with tables, diagrams, and figures making the intricacies of neurochemistry easy to understand, it builds a solid understanding of major disease mechanisms by reviewing the effects of drug actions (organized by drug category), and it explains the neuropharmacology of specific neural and psychiatric disorders. Concise overviews of the effects of drugs and neurologically active substances appear before the descriptions of the minute details that lead to these effects—a format designed to boost understanding and knowledge retention of critical concepts.

Neuropsychopharmacology is a relatively new subject area in the neurosciences. It is a field of study that describes the effects of drugs from the molecular to the behavioural level and requires integration and synthesis of knowledge from various disciplines including neuroanatomy, physiology, molecular biology, pharmacology and the behavioural sciences. The principal aims of this book are to provide students with a clear understanding of CNS disorders, and an appreciation of how basic and clinical research findings can be translated into therapeutics. After an introduction to the subject area, the remaining chapters are focused on reviewing the main psychiatric and neurological disorders that are covered in most courses. They are discussed in terms of their clinical symptoms, epidemiology, pathology, aetiology, underlying neurobiological and neurochemical mechanisms, pharmacotherapy, adjunctive non-pharmacological treatments, and clinical outcomes. Each chapter of the book is a ‘stand-alone’ chapter and is written in a clear, accessible style. Written by an author with many years teaching and research experience, this textbook will prove invaluable for students of pharmacology, pharmacy and the medical sciences needing a truly integrated introduction to this exciting field.