The horrifying terrorist attacks on September 11, 2001, and the anthrax strikes that soon followed gave the United States new reason to fear unconventional enemies and atypical weapons. These fears have prompted extensive research, study, and planning within the U.S. military, intelligence, and policy communities regarding potential attacks involving biological weapons. In Phantom Menace or Looming Danger?, Kathleen M. Vogel argues for a major shift in how analysts assess bioweapons threats. She calls for an increased focus on the social and political context in which technological threats are developed. Vogel uses case studies to illustrate her theory: Soviet anthrax weapons development, the Iraqi mobile bioweapons labs, and two synthetic genomic experiments. She concludes with recommendations for analysts and policymakers to integrate sociopolitical analysis with data analysis, thereby making U.S. bioweapon assessments more accurate. Students of security policy will find her innovative framework appealing, her writing style accessible, and the many illustrations helpful. These features also make Phantom Menace or Looming Danger? a must-read for government policymakers and intelligence experts. -- Lynn Eden, Center for International Security and Cooperation, Freeman Spogli Institute for International Studies, Stanford University

This monograph introduces current genome editing technologies—clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated (Cas) systems, transcription activator-like effector nucleases (TALENs), and zinc-finger nucleases (ZFNs)—and provides an assessment of the risk of misuse of these technologies based on the following parameters: accessibility, ease of misuse, magnitude of potential harm, and imminence of potential misuse. The findings from this assessment are applied to analyze and evaluate the threat posed by the intentional misuse of genome editing technologies to develop biological weapons. Furthermore, the book discusses the implications of misuse for different applications of genome editing, such as making existing pathogens more dangerous, modifying the human microbiome, weaponizing gene drives, engineering super soldiers, and augmenting the general population to confer economic advantages. Technologies that enable genome editing with programmable nucleases—including CRISPR, TALEN, and ZFN—allow for the precise genetic modification of organisms and cultured cells. While these technologies are used for a variety of beneficial applications, intelligence and defense experts have raised concerns that genome editing technologies, especially CRISPR, could be misused to develop new and improved biological weapons. Furthermore, experts worry that the number and type of actors who could potentially misuse genome editing is dramatically increasing given the democratization of biology, which is allowing biology to become more accessible to everyone including nonexperts. The book provides a comprehensive assessment of how feasible it is for users with different levels of knowledge and skill to acquire and then to apply the technologies to develop a biological weapon. It also provides an assessment of governability and a tailored set of recommendations that address security concerns. These recommendations are sensitive to the cost-benefit trade-off of regulating genome editing technologies. The book targets researchers as well as intelligence analysts, defense and security personnel, and policymakers.

A TIMES ENVIRONMENT AND SCIENCE BOOK OF THE YEAR 2022 'The ideal guide to what is not just a fiendishly complex area of science but also an ethical minefield' Mail on Sunday A new gene editing technology, invented just seven years ago, has turned humanity into gods. Enabling us to manipulate the genes in virtually any organism with exquisite precision, CRISPR has given scientists a degree of control that was undreamt of even in science fiction. But CRISPR is just the latest, giant leap in a long journey to master genetics. The Genetic Age shows the astonishing, world-changing potential of the new genetics and the possible threats it poses, sifting between fantasy and the reality when it comes to both benefits and dangers. By placing each phase of discovery, anticipation and fear in the context of over fifty years of attempts to master the natural world, Matthew Cobb, the Baillie-Gifford-shortlisted author of The Idea of the Brain, weaves the stories of science, history and culture to shed new light on our future. With the powers now at our disposal, it is a future that is almost impossible to imagine - but it is one we will create ourselves.

This book explores the absent and missing in debates about science and security. Through varied case studies, including biological and chemical weapons control, science journalism, nanotechnology research and neuroethics, the contributors explore how matters become absent, ignored or forgotten and the implications for ethics, policy and society.The chapter 'Sensing Absence: How to See What Isn't There in the Study of Science and Security' is open access under a CC BY 4.0 license via link.springer.com.

In both the popular imagination and among lawmakers and national security experts, there exists the belief that with sufficient motivation and material resources, states or terrorist groups can produce bioweapons easily, cheaply, and successfully. In Barriers to Bioweapons, Sonia Ben Ouagrham-Gormley challenges this perception by showing that bioweapons development is a difficult, protracted, and expensive endeavor, rarely achieving the expected results whatever the magnitude of investment. Her findings are based on extensive interviews she conducted with former U.S. and Soviet-era bioweapons scientists and on careful analysis of archival data and other historical documents related to various state and terrorist bioweapons programs.Bioweapons development relies on living organisms that are sensitive to their environment and handling conditions, and therefore behave unpredictably. These features place a greater premium on specialized knowledge. Ben Ouagrham-Gormley posits that lack of access to such intellectual capital constitutes the greatest barrier to the making of bioweapons. She integrates theories drawn from economics, the sociology of science, organization, and management with her empirical research. The resulting theoretical framework rests on the idea that the pace and success of a bioweapons development program can be measured by its ability to ensure the creation and transfer of scientific and technical knowledge. The specific organizational, managerial, social, political, and economic conditions necessary for success are difficult to achieve, particularly in covert programs where the need to prevent detection imposes managerial and organizational conditions that conflict with knowledge production.

Written by an award-winning historian of science and technology, Planet in Peril describes the top four mega-dangers facing humankind – climate change, nukes, pandemics, and artificial intelligence. It outlines the solutions that have been tried, and analyzes why they have thus far fallen short. These four existential dangers present a special kind of challenge that urgently requires planet-level responses, yet today's international institutions have so far failed to meet this need. The book lays out a realistic pathway for gradually modifying the United Nations over the coming century so that it can become more effective at coordinating global solutions to humanity's problems. Neither optimistic nor pessimistic, but pragmatic and constructive, the book explores how to move past ideological polarization and global political fragmentation. Unafraid to take intellectual risks, Planet in Peril sketches a plausible roadmap toward a safer, more democratic future for us all.

This book examines the threat of a terrorist organisation constructing and detonating a nuclear bomb. It explores the role and impact of the organisational design of a terrorist organisation in implementing a nuclear terrorism plot. In order to do so, the work builds on the organisational analogy between an assumed nuclear terrorism scenario and four case studies as follows: the construction of the first atomic bombs at Los Alamos; South Africa’s Peaceful Nuclear Explosives (PNE) program; Aum Shinrikyo’s chemical-biological armament activities; and Al Qaeda’s implementation of the 9/11 attacks. Extrapolating insights from these case studies, this book introduces the idea of an effectiveness-efficiency trade-off. On the one hand, it will be argued that a more organic organisational design is likely to benefit the effective implementation of a nuclear terrorism project. On the other hand, this type of organic organisational design is also likely to simultaneously constitute an inefficient way for a terrorist organisation to guarantee its operational and organisational security. It follows, then, that the implementation of a nuclear terrorism plot via an organic organisational design is also likely to be an inefficient strategy for a terrorist organisation to achieve its strategic and political goals. This idea of an effectiveness-efficiency trade-off provides us with a tool to strengthen the comprehensive nature of future nuclear terrorism threat assessments and sheds new light on the ongoing debates within the nuclear terrorism literature. This book will be of particular interest to students of nuclear proliferation, terrorism studies, international organisations, and security studies in general.

A call for a new way to assess bioweapon threats—recognizing the importance of the sociopolitical context of technological threats. The horrifying terrorist attacks on September 11, 2001, and the anthrax strikes that soon followed gave the United States new reason to fear unconventional enemies and atypical weapons. These fears have prompted extensive research, study, and planning within the U.S. military, intelligence, and policy communities regarding potential attacks involving biological weapons. In Phantom Menace or Looming Danger?, Kathleen M. Vogel argues for a major shift in how analysts assess bioweapons threats. She calls for an increased focus on the social and political context in which technological threats are developed. Vogel uses case studies to illustrate her theory: Soviet anthrax weapons development, the Iraqi mobile bioweapons labs, and two synthetic genomic experiments. She concludes with recommendations for analysts and policymakers to integrate sociopolitical analysis with data analysis, thereby making U.S. bioweapon assessments more accurate. Students of security policy will find her innovative framework appealing, her writing style accessible, and the many illustrations helpful. These features also make Phantom Menace or Looming Danger? a must-read for government policymakers and intelligence experts. “This is an engrossing book that exemplifies what STS can bring to broader issues of policymaking in the US and potentially beyond, and it is well worth reading.” —Carla Nappi, New Books in Science, Technology, and Society “Kathleen Vogel has authored one of the most important books written about biological weapons in recent years. . . . Vogel tackles head-on the conventional wisdom regarding the biological weapon (BW) threat, successfully, challenging assumptions that have gone largely unexamined by the broader biodefense community. . . . She also uncovers some deeper organizational and social forces that have shaped US intelligence and threat assessments since the end of international security, not just those with an interest in biodefense or intelligence. This, this book is a must-read for scholars and practitioners in the field of international security, not just those with an interest in biodefense or intelligence.” —Gregory D. Koblentz, Nonproliferation Review “Intriguing, original, and deeply informed. Focusing on potential threats, Vogel shows in engaging historical detail that technical problems are inherently social. She has made an important scholarly contribution to science and technology studies and to studies of intelligence. At the same time, she speaks directly to the policy world. The combination of depth of scholarship and practical implication is remarkable.” —Lynn Eden, Center for International Security and Cooperation, Freeman Spogli Institute for International Studies, Stanford University

Biosecurity Dilemmas examines conflicting values and interests in the practice of “biosecurity,” the safeguarding of populations against infectious diseases through security policies. Biosecurity encompasses both the natural occurrence of deadly disease outbreaks and the use of biological weapons. Christian Enemark focuses on six dreaded diseases that governments and international organizations give high priority for research, regulation, surveillance, and rapid response: pandemic influenza, drug-resistant tuberculosis, smallpox, Ebola, plague, and anthrax. The book is organized around four ethical dilemmas that arise when fear causes these diseases to be framed in terms of national or international security: protect or proliferate, secure or stifle, remedy or overkill, and attention or neglect. For instance, will prioritizing research into defending against a rare event such as a bioterrorist attack divert funds away from research into commonly occurring diseases? Or will securitizing a particular disease actually stifle research progress owing to security classification measures? Enemark provides a comprehensive analysis of the ethics of securitizing disease and explores ideas and policy recommendations about biological arms control, global health security, and public health ethics.

This volume provides an authoritative, cutting-edge resource on the characteristics of both technological and social change in warfare in the twenty-first century, and the challenges such change presents to international law. The character of contemporary warfare has recently undergone significant transformation in several important respects: the nature of the actors, the changing technological capabilities available to them, and the sites and spaces in which war is fought. These changes have augmented the phenomenon of non-obvious warfare, making understanding warfare one of the key challenges. Such developments have been accompanied by significant flux and uncertainty in the international legal sphere. This handbook brings together a unique blend of expertise, combining scholars and practitioners in science and technology, international law, strategy and policy, in order properly to understand and identify the chief characteristics and features of a range of innovative developments, means and processes in the context of obvious and non-obvious warfare. The handbook has six thematic sections: Law, war and technology Cyber warfare Autonomy, robotics and drones Synthetic biology New frontiers International perspectives. This interdisciplinary blend and the novel, rich and insightful contribution that it makes across various fields will make this volume a crucial research tool and guide for practitioners, scholars and students of war studies, security studies, technology and design, ethics, international relations and international law.