In Perishing Heathens Julius H. Rubin tells the stories of missionary men and women who between 1800 and 1830 responded to the call to save Native peoples through missions, especially the Osages in the Arkansas Territory, Cherokees in Tennessee and Georgia, and Ojibwe peoples in the Michigan Territory. Rubin also recounts the lives of Native converts, many of whom were from mixed-blood métis families and were attracted to the benefits of education, literacy, and conversion. During the Second Great Awakening, Protestant denominations embraced a complex set of values, ideas, and institutions known as "the missionary spirit." These missionaries fervently believed they would build the kingdom of God in America by converting Native Americans in the Trans-Appalachian and Trans-Mississippi West. Perishing Heathens explores the theology and institutions that characterized the missionary spirit and the early missions such as the Union Mission to the Osages, and the Brainerd Mission to the Cherokees, and the Moravian Springplace Mission to the Cherokees. Through a magnificent array of primary sources, Perishing Heathens reconstructs the millennial ideals of fervent true believers as they confronted a host of impediments to success: endemic malaria and infectious illness, Native resistance to the gospel message, and intertribal warfare in the context of the removal of eastern tribes to the Indian frontier.

American ideas about race owe much to the notion of an undifferentiated “heathen world” held together by its need of assistance. This religious notion shaped American racial governance and undergirds American exceptionalism, even as purported heathens have drawn on their characterization as such to push back against this national myth.

Volumes for 1828-1934 contain the Proceedings at large of the American Board of Commissioners for Foreign Missions.

Vols. for 1970- include "Calendar of prayer" with directory of missionaries (formerly called pt. 3)