All anesthesiologists are confronted with patients who show bleeding disorders, whether congenital, acquired, or pharmacologically induced. Although many studies, meta-analyses, guidelines, and textbooks have been published on the subject, they mostly cover specific aspects or require a thorough knowledge of hemostasis. The goal of this book is to provide the anesthesiologist with an overview of hemostasis and the mechanisms underlying bleeding and coagulation in general and to assist in the understanding of specific coagulation disorders as they may occur in the various anesthesia subspecialties. It is hoped that, through the provision of practical information and tools, the book will help residents and trained anesthesiologists to manage one of the most frustrating challenges that they face: the bleeding patient. A full understanding of coagulation requires a lifelong career, and this book is not intended to replace the consulting hematologist, whose expert opinion should always be sought. The available procoagulant blood products and drugs all have potentially dangerous side-effects; furthermore, in bleeding disorders pitfalls are frequent and a misdiagnosis can have potentially catastrophic consequences. The aim of the editors is thus instead to enhance the collaboration between the disciplines of Anesthesiology and Hematology.

This unique volume presents the cutting edge of haemostasis in surgery and includes the advances in the science pertaining to related important medical and surgical problems. It is the only book that includes all the surgical subspecialties focusing specifically on the problems of haemostasis in each field. State-of-the-art laboratory and clinical reviews are included and modern devices used in the different specialties are also covered. The contributors are well-known authorities in their special fields and haematological area. Each is covered comprehensively with special emphasis on unanswered questions. The book is addressed to all surgeons and physicians with an interest in this exciting field.

Meeting the needs of patients while minimizing blood transfusions requires special expertise, precise monitoring and innovative techniques. This cutting-edge resource covers all the important clinical aspects of transfusion medicine in diverse clinical settings, with a special emphasis on alternatives to transfusion. Edited by a multidisciplinary team consisting of a transfusion specialist, an anesthesiologist and an intensive care specialist this book is endorsed by the Network for Advancement of Transfusion Alternatives. The contributors review the appropriate use of fluids and of blood products, and describe the latest treatment options available to decrease the need for allogeneic blood products including: Argon beam Cell saver Harmonic scalpel Normovolemic haemodilution Synthetic erythropoietin Antifibrinolytics Recombinant factor VIIa Advanced monitoring of hemostasis Intravenous iron The new edition is a key reference source for all those involved in the practice of blood management and conservation.

This book offers a thorough, clinically oriented review of hemostasis and its impact on the practice of dentistry. Readers will gain a sound understanding of the pathophysiology of hemostasis and the pharmacology of antithrombotic and prothrombotic medications. Perioperative dental management strategies of value in patients with different congenital and acquired disorders of hemostasis are carefully explained, and the role of surgical techniques and local and topical agents in helping to minimize and control bleeding is described. Helpful instruction is also provided on the indications for antithrombotic medications and the management of patients receiving such therapy, including the risks of altering medications. As the number of available oral antithrombotic agents continues to increase, dentists will encounter significantly more patients receiving treatments that affect hemostasis. In presenting comprehensive, up-to-date information on hemostasis, hemostatic disorders, antithrombotic therapy, and safe dental management, this book will serve as a rich source of information and a useful guide for practitioners and students alike.

A unique clinical focus makes Consultative Hemostasis and Thrombosis, 3rd Edition your go-to guide for quick, practical answers on managing the full range of bleeding and clotting disorders. Emphasizing real-world problems and solutions, Dr. Craig S. Kitchens, Dr. Barbara A. Konkle, and Dr. Craig M. Kessler provide all the clinical guidance you need to make optimal decisions on behalf of your patients and promote the best possible outcomes. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Efficiently look up concise descriptions of each condition, its associated symptoms, laboratory findings, diagnosis, differential diagnosis, and treatment. Get the latest information on hot topics such as Disseminated Intravascular Coagulation, Thrombophilia, Clinical and Laboratory Assessment and Management, Thrombotic -Thrombocytopenic Purpura, and Heparin-Induced Thrombocytopenia. Apply today’s newest therapies, including those that are quickly becoming standard in this fast-changing field. Meet the needs of specific patient groups with a new chapter on Bleeding and the Management of Hemorrhagic Disorders in Pregnancy and an extensively updated chapter on Thrombosis and Cancer. Zero in on key information with a new user-friendly design, and all-new full-color format, abundant laboratory protocols, and at-a-glance tables and charts throughout.

Medical knowledge about blood, its use in transfusions, and blood products has grown exponentially, as well as awareness about its safety, risks and costs. In a discipline where risks are proportional to benefits, medical specialists involved in open heart surgery need to have the latest information to make informed decisions. Dr. Attar's work reflects the contributors' direct interest and experience in blood and cardiac surgery introducing the latest information on blood and its use, hemostasis, blood conservation techniques and safety, the risks involved, alternatives to blood transfusions, the diagnosis and therapy of coagulopathy associated with cardiac surgery, and medicolegal aspects. Medical advances include the latest intraoperative diagnostic measures for platelet functions and therapy strategies for hemostasis abnormalities with cardiac surgery. This work is unique for its extensive and critical description of instruments and tests used intraoperatively, especially for the evaluation of the coagulation factors and platelets, the algorithms for transfusion guidelines and the detailed application of APROTININ and other antifibrinolytic agents in minimizing bleeding in cardiac surgery. Written for cardiac and transplant specialists -- from surgeons, anesthesiologists, surgical nurses to perfusionists -- this valuable and timely reference thoroughly explores the subject of blood transfusions in open heart surgery, its clinical applications, the current status of blood substitutes and important legal aspects.

The second edition of Transfusion Medicine and Hemostasis continues to be the only "pocket-size" quick reference for pathology residents and transfusion medicine fellows. It covers all topics in blood banking, transfusion medicine, and clinical and laboratory based coagulation. Short, focused chapters, organized by multiple hierarchical headings, are supplemented with up to 10 suggested reading citations. This single reference covers essentially all the topics required to meet the goals and objectives of a major program in transfusion medicine and clinical coagulation. New chapters in the coagulation testing section reflect the development of new tests available and their incorporation into clinical practice. Coverage includes essential updates on the importance of new cellular therapies, peripheral blood and bone marrow hematopoietic progenitor cells, as well as cord blood banking and regenerative medicine. The authors also examine advances in the understanding of molecular testing and pathogen reduction in two separate quality control chapters (one for blood centers and one for hospitals). - Updated content covers new coagulation tests, cellular therapies, and quality control issues - Easy to use, with focused, well-defined chapters in a standardized format throughout - Offers quick "cross-reference" lists at the end of each chapter - Includes lists of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities

A definitive, accessible, and reliable resource which provides a solid foundation of the knowledge and basic science needed to hone all of the core surgical skills used in surgical settings. Presented in a clear and accessible way it addresses the cross-specialty aspects of surgery applicable to all trainees.

The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.

Hemostasis Management of the Pediatric Surgical Patient provides knowledge on the emerging area of pediatric hemostasis and its management. It discusses aspects of perioperative blood management in the pediatric population, including how to accurately estimate and monitor bleeding and determine optimal treatment regimens for bleeding in pediatric surgical patients. It also provides information on the implementation of intraoperative blood conservation strategies, goal-directed transfusion therapy, and postoperative estimation of bleeding and thrombotic risks. This book is a valuable resource to pediatric practitioners and researchers who need comprehensive information on pediatric hematology, from basic physiology to pre-, intra- and postoperative care of pediatric patients. The coagulation system of children evolves with age as evidenced by marked physiological differences in the concentration of hemostatic proteins between children of different age groups and adults. Consequently, there are distinct differences in hemostatic management between adult and pediatric patients. - Covers essential concepts in hemostasis, indicating instances where pediatric and adult data conflict, along with foundational information on disorders of hemostasis in children and blood bank management for pediatric patients - Concisely covers specifics of perioperative hemostatic management in neonates and children, including bedside monitoring of coagulation and goal-directed treatment of coagulopathy - Discusses hemostatic management in the entire perioperative period, from preoperative assessment until discharge from the hospital