This issue is a must-read for perinatologists and neonatologists who need current advances in treastment and interventions to improve the viability of the neonate. The Guest Editors have put together a concise monograph on the topic, offering the most current clinica review articles on the following topics: Antenatal corticosteroids: Who should we be treating?; Quality improvement strategies to improve care of women in preterm labor; Delivery at term: when, how, and why?; Detection and prevention of perinatal infection; Current strategies to prevent perinatal HIV transmission; Advances in fetal monitoring and association with outcomes; Relationship between perinatal interventions, the maternal-infant microbiome and neonatal outcomes; Understanding outcomes and couseling families at a periviable gestational age; Therapeutic hypothermia - how can we optimize this therapy to further improve outcomes; Reducing CPAP failure in extremely preterm infants; Optimizing caffeine therapy in preterm infants; Improving uptake of key perinatal interventions using state-wide quality collaboratives; Oxygen therapy in the delivery room: What is the right dose?; and Perinatal white matter injury: prevention and long-term outcomes. Readers will leave with the best evidence they need to improve outcomes.

This issue is a must-read for perinatologists and neonatologists who need current advances in treastment and interventions to improve the viability of the neonate. The Guest Editors have put together a concise monograph on the topic, offering the most current clinica review articles on the following topics: Antenatal corticosteroids: Who should we be treating?; Quality improvement strategies to improve care of women in preterm labor; Delivery at term: when, how, and why?; Detection and prevention of perinatal infection; Current strategies to prevent perinatal HIV transmission; Advances in fetal monitoring and association with outcomes; Relationship between perinatal interventions, the maternal-infant microbiome and neonatal outcomes; Understanding outcomes and counseling families at a periviable gestational age; Therapeutic hypothermia - how can we optimize this therapy to further improve outcomes; Reducing CPAP failure in extremely preterm infants; Optimizing caffeine therapy in preterm infants; Improving uptake of key perinatal interventions using state-wide quality collaboratives; Oxygen therapy in the delivery room: What is the right dose?; and Perinatal white matter injury: prevention and long-term outcomes. Readers will leave with the best evidence they need to improve outcomes.

The Guest Editors have collaborated on a state-of-the-art presentation of current clinical reviews on Quality in Neonatal Care. Top experts have prepared articles in the following areas: Standardizing Practices: How and why to standardize, using checklists, measuring variation; Health Informatics and Patient Safety; Using Statistical Process Control to Drive Improvement in Neonatal Care; Improving Value in Neonatal Intensive Care; Culture and Context in Quality of Care: Improving Teamwork and Resilience; Has Quality Improvement Improved Neonatal Outcomes; National Quality Measures in Perinatal Care; Perinatal and Obstetric Quality Initiatives; Family Involvement in Quality Improvement; Perinatal Quality Improvement: A Global Perspective; Delivery Room Care / Golden Hour; Respiratory Care and Bronchopulmonary Dysplasia; Reducing Incidence of Necrotizing Enterocolitis; Alarm Safety and Alarm Fatigue; and Patient Safety: Reducing Unplanned Extubations. Readers will come away with the clinical information they need improve quality in the NICU.

This issue of Clinics in Perinatology, guest edited by Drs. Alan Spitzer and Dan Ellsbury, examines Quality Improvement in Neonatal and Perinatal Medicine. The first part of the issue addresses Tools of Quality Improvement and includes articles on The Quality Chasm in Neonatal and Perinatal Medicine; Evaluating the Medical Evidence; The Vermont Oxford Network Database; The Pediatrix Clinical Data Warehouse; Role of Regional Collaboratives: The California Perinatal Quality Care Collaborative Model; A Primer on Quality Improvement Methodology; Using Statistical Process Control Methodology; Human Factors in Quality Improvement, Random Safety Audits, Root Cause Analysis, and Failure Mode and Effects Analysis; Collaboration Between Obstetricians and Neonatologists: Perinatal Safety Programs and Improved Clinical Outcomes; and Pay for Performance: A Business Strategy for Quality Improvement in Neonatal-Perinatal Medicine. The second part of this issue addresses Specific Applications of Documented Quality Improvement Methodology in Neonatal and Perinatal Medicine and includes articles on Delivery Room Intervention-Improving the Outcome, Reducing Retinopathy of Prematurity, Improving Breast Milk Use During and After the NICU Stay, Decreasing Catheter Related Bloodstream Infection, and Decreasing Bronchopulmonary Dysplasia.

In this issue of Clinics in Perinatology, guest editors Drs. Heather C. Kaplan and Munish Gupta bring their considerable expertise to the topic of Quality Improvement. In recent years, the growing use of quality improvement (QI) methods to apply evidence-based practices to clinical care has resulted in a greater penetration of QI methods in neonatal intensive care units across the world and a more sophisticated appreciation of how best to use them. This issue provides important updates in these areas as well as looks at the future of QI in perinatology. Contains 15 practice-oriented topics including frameworks for quality improvement: Lean Six Sigma and the model for improvement in perinatology; sustaining improvement in perinatology; recent progress in global health quality improvement in perinatology; measuring equity for quality improvement in perinatology; pursuing equity for all mothers and newborns through population health: the role of perinatal quality collaboratives; and more. Provides in-depth clinical reviews on quality improvement in perinatology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Clinics in Perinatology, guest editors Drs. Nathalie Maitre and Andrea F. Duncan bring their considerable expertise to the topic of Neurological and Developmental Outcomes of High-Risk Neonates. Preterm birth complications are the leading cause of death among children under five years of age, and three-quarters of these deaths could be prevented with current, cost-effective interventions. In this issue, top experts provide neonatologists and perinatologists with the clinical information they need to improve outcomes in high-risk newborns. - Contains 15 practice-oriented topics including neonatal opioid withdrawal syndrome; healthcare disparities in high-risk neonates; autism spectrum and high-risk infant phenotypes; NICU transition to home interventions; telehealth and other innovations in NICU follow up; and more. - Provides in-depth clinical reviews on neurological and developmental outcomes of high-risk neonates, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Clinics in Perinatology, Guest Editors Anup Katheria and Lisa Stellwagen bring their considerable expertise to the topic of Care for the Term Newborn. Top experts in the field cover key topics such as delivery room triage and transitions of care; early onset sepsis; congenital infections; postnatal screening & testing; and more. - Provides in-depth, clinical reviews on Care for the Term Newborn, providing actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. - Contains 14 relevant, practice-oriented topics including Umbilical Cord Management for vigorous and non-vigorous infants; Fetal Circulation and Critical Congenital Cardiac Disease; Alternative Birth Practices, Refusal, and Therapeutic Hesitancy; Prenatal Substance Exposure; and more.

There is general consensus regarding threshold levels that describe the gray zone on the limits of viability, and gestational age alone should not be used solely in making a decision. This issue will bring light to the latest thoughts and clinical recommendations for delivery during the periviable period. Top thought leaders and clinicians have submitted articles in the following areas: Consequences of Birth at Periviable Gestions on Organ Systems; Medical and Surgical Interventions Before Birth; NICU Care: Nutrition/NEC; Pulmonary Care and Circulatory Support; NICU Stay and Microbiome; and Ethical Considerations and Counseling, to name a few. Readers will come away with the most current content written on this topic and details that can be incorporated into clinical care.

Neonatal-perinatal medicine has a strong history of evidence based practice but unfortunately there remain many areas of uncertainty and unproven hypotheses and treatments that may harm our highly vulnerable patients. When new ideas are introduced into the labor and delivery room or the NICU we have to evaluate these procedures and therapies before they become accepted as standards of care. We need to learn from the past lessons of grey baby syndrome and chloramphenicol and of kernicterus and sulfonamide antibiotics where therapeutic good intentions actually did more harm than good and increased the mortality rate of premature babies in the NICU.This proposed edition addresses a broad range of current topics in perinatal neonatal practice. The AAP has just issued new guidelines for the approach to a neonate exposed to maternal genital herpes virus infection. The recommendations were not evidence based and are highly controversial as well as confusing. These topics are addressed in a scholarly and objective manner to both address the controversy and help the practitioner make informed decisions.

In this issue of Clinics in Perinatology, guest editors Drs. David K. Stevenson and Gary M. Shaw, along with research scientist Ron J. Wong, bring their considerable expertise to the topic of Preterm Birth. Preterm birth is the leading cause of death among children, with one million children dying due to preterm birth before the age of five years. This issue is a key resource for perinatologists who seek to predict and improve outcomes for preterm births, providing actionable clinical information in hopes of reaching the United Nations Sustainable Development Goal to end all preventable deaths of newborns and children aged under five years by 2030. - Contains 15 practice-oriented topics including genomics of preterm birth; predicting preterm birth using proteomics; predicting preterm birth using the microbiome; predicting preterm birth using the immunome; a new taxonomy of preterm birth; and more. - Provides in-depth clinical reviews of preterm birth, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.