Pathology is no longer the" dead science" it was reputed to be a few decades ago. The famous Canadian pathologist, William Boyd, expressed the newer attitude aptly when he stated that pathology should no longer be concerned simply with describing the" WHAT" of disease, but must be increasingly con cerned with the "HOW" and the "WHY". By this he implied that the preoccupa tion of the usual student of disease in the architecture of diseased tissues and descriptions of participating cells, their staining characteristics, etc. , must give way to study and understanding of the dynamics of each disease process, the pathogenetic mechanisms producing the changes in body tissues. This study is not limited simply to etiologic factors and portals of entry to the site of the lesion, but includes the physical and chemical factors involved, the variations of host response conditioned by immunologic reactions of differing intensities, enzymatic excesses or deficiencies, and a host of other variables of little known character such as the prostaglandins which definitely affect the disease process. No longer is the pathologist one who looks at sections of diseased tissue merely for differentiation of disease, but truly a pathologist studies disease.

Pathology and Pathobiology of Rheumatic Diseases glows with the uncommon precision of the pathologist, the clarity of the tea cher, and the unswerving commitment of the investigator. Fass bender has produced a major contribution to the literature of rheumatic diseases. The practical experience and wisdom brought together in this book, substantiated by excellent exam ples of histopathology, produce a landmark for all who have made the study of rheumatic diseases their profession. The enor mous achievements made in molecular biology, genetics, struc tural biochemistry, and clinical science have been assembled in this book to interact in a meaningful way with the anatomical histology of the rheumatic diseases. It is not easy for any single investigator to paint the picture of a disease process, from its clinical description to its mechanisms, and then to a defined hypothesis, and finally an understanding. Nonetheless, Fassbender has done this in a clear and convincing way that integrates our current knowledge of this group of dis eases. Scientific discovery in medicine moves from the bedside to the bench, back to the bedside, and then back to the bench, etc. It is this iterative process of new observation and new discovery that has given us the achievements in medicine over the past century.

Acute Rheumatic Fever and Rheumatic Heart Disease is a concise, yet comprehensive, clinical resource highlighting must-know information on rheumatic heart disease and acute rheumatic fever from a global perspective. Covering the major issues dominating the field, this practical resource presents sufficient detail for a deep and thorough understanding of the latest treatment options, potential complications, and disease management strategies to improve patient outcomes. - Divided into four distinct sections for ease of navigation: Acute Rheumatic Fever, Rheumatic Heart Disease, Population-Based Strategies for Disease Control, and Acute and Emergency Presentations. - International editors and chapter authors ensure a truly global perspective. - Covers all clinical aspects, including epidemiology, pathophysiology, clinical features, diagnosis, management, and treatment. - Includes key topics on population-based measures for disease control for effective primary, secondary, and tertiary prevention. - Consolidates today's available information and guidance into a single, convenient resource.

This book covers all fields in rheumatology and aims to help readers comprehend, familiarize and evaluate their knowledge of the subject area. It contains short questions and concise answers on definitions, pathogenetic aspects, clinical and laboratory manifestations, differential diagnosis and the management of all rheumatic diseases. The book also provides questions and answers on major aspects of basic immunology, valuable for understanding underlying immunological mechanisms of autoimmune rheumatic diseases. Illustrations and images help present information in a clear and schematic way.

This is one of the most prestigious and comprehensive texts on arthritis and related diseases, including osteoarthritis, rheumatoid arthritis, osteoporosis, lupus and more than one hundred others. It offers medical students and physicians a concise description of the current science, diagnosis, clinical consequences, and principles of management. New and expanded chapters heighten the translational nature of this edition. Students, trainees, and practicing clinicians all need a standard textbook that can change with the times and reflect recent strides taken in understanding and treating rheumatic disease. The Primer fills that need.

This Open Access book presents practical approaches to managing patients affected by various rheumatological diseases, allowing readers to gain a better understanding of the various clinical expressions and problems experienced by these patients. Discussing rheumatology from an organ systems perspective, it highlights the importance ofdetailed musculoskeletal examinations when treating patients affected by rheumatological diseases. The book first explores the latest diagnostic approaches and offers key tips for accurate musculoskeletal examinations before addressing the various treatment modalities, with a particular focus on the most common joints involved in rheumatoid arthritis: the wrists and the metacarpophalangeal joints (2nd and 3rd). Featuring easy-to-understand flow diagrams and explaining the common medical problems associated with rheumatic disease, such as shortness of breath and anemia, it is not only a valuable resource to rheumatologists, but will also appeal to medical students, junior residents, and primary healthcare physicians.

A Synopsis of Rheumatic Diseases presents the study and practice of rheumatology. It discusses the aetiology, diagnosis, and management of the rheumatic disorders. It addresses the scientific work on antinuclear antibodies and extractable nuclear antigens. Some of the topics covered in the book are the biology of synovial joints and connective tissue; immunological principles of rheumatic disorders; pathology of the inflammatory reaction; examination of the locomotor system; classification of rheumatic disorders; rehabilitation in chronic arthritis; and the major rheumatic diseases. The rheumatism due to extra-articular causes is covered. The arthritis associated with skin disorders is discussed. The text describes the neoplasms of synovial membrane and tendon sheaths. A study of the hereditary connective-tissue disorders and psychogenic rheumatism is presented. A chapter is devoted to the limb pain syndromes. Another section focuses on the cervical pain and brachial neuralgia. The book can provide useful information to radiologists, doctors, physical therapists, students, and researchers.

The ability to intervene at the earliest phases in the pathogenesis of a chronic rheumatic disease caused by auto-inflammatory, autoimmune, or tissue injury mechanisms has th epotential to prevent disease manifestations and consequences, limited loss of quality of life, comorbidity, and costs to society. This issue is dedicated to exploring the stages of rheumatic disease, biologic mechanisms contributing to the pathogenesis along with possible ways to study and screen for persons at risk with the ultimate goal of finding ways to prevent these devastating diseases.

What medicine lacks in an increasingly specialised world is the medical polymath (or should it be medical bimath?) - the man who is an acknowledged expert in more than one field of medicine. Super§pecialisation in the professional sense is an attempt to know more and more about less and less. It can be the microscopist's view of reality and such a microcosm can become also a refuge from realities. One reality difficult for the very specialised doctor to accept is that diseases don't exist. Only people with diseases exist and people do not always conform to convenient categories and compartments. It would be nice if they did but somehow they never do. A cherished medical tradition in Britain is that specialists are not hatched straight from medical schools. Indeed, young doctors are actively discouraged from taking too narrow an interest but are plunged for at least four years into the unspecific pool of general medicine until they have developed a broad awareness of the totality of human disease. Before this they are not allowed to narrow their sights on one particular target.