This is the harrowing account of one of the most ill-fated expeditions in maritime history. Of five ships that sailed from Rotterdam at the turn of the 16th century, only one reached the largely unknown islands of Japan. The pilot of that ship was the inspiration for the hero of James Clavell's Shogun.

"David Abulafia's new book guides readers along the world's greatest bodies of water to reveal their primary role in human history. The main protagonists are the three major oceans-the Atlantic, the Pacific, and the Indian-which together comprise the majority of the earth's water and cover over half of its surface. Over time, as passage through them gradually extended and expanded, linking first islands and then continents, maritime networks developed, evolving from local exploration to lines of regional communication and commerce and eventually to major arteries. These waterways carried goods, plants, livestock, and of course people-free and enslaved-across vast expanses, transforming and ultimately linking irrevocably the economies and cultures of Africa, Europe, Asia, and the Americas"--

Your no-nonsense guide to genetics With rapid advances in genomic technologies, genetic testing has become a key part of both clinical practice and research. Scientists are constantly discovering more about how genetics plays a role in health and disease, and healthcare providers are using this information to more accurately identify their patients' particular medical needs. Genetic information is also increasingly being used for a wide range of non-clinical purposes, such as exploring one's ancestry. This new edition of Genetics For Dummies serves as a perfect course supplement for students pursuing degrees in the sciences. It also provides science-lovers of all skill levels with easy-to-follow and easy-to-understand information about this exciting and constantly evolving field. This edition includes recent developments and applications in the field of genetics, such as: Whole-genome and whole-exome sequencing Precision medicine and pharmacogenetics Direct-to-consumer genetic testing for health risks Ancestry testing Featuring information on some of the hottest topics in genetics right now, this book makes it easier than ever to wrap your head around this fascinating subject.

The Dutch East India Company was a hybrid organization combining the characteristics of both corporation and state that attempted to thrust itself aggressively into an Asian political order in which it possessed no obvious place and was transformed in the process. This study focuses on the company's clashes with Tokugawa Japan over diplomacy, violence, and sovereignty. In each encounter the Dutch were forced to retreat, compelled to abandon their claims to sovereign powers, and to refashion themselves again and again—from subjects of a fictive king to loyal vassals of the shogun, from aggressive pirates to meek merchants, and from insistent defenders of colonial sovereignty to legal subjects of the Tokugawa state. Within the confines of these conflicts, the terms of the relationship between the company and the shogun first took shape and were subsequently set into what would become their permanent form. The first book to treat the Dutch East India Company in Japan as something more than just a commercial organization, The Company and the Shogun presents new perspective on one of the most important, long-lasting relationships to develop between an Asian state and a European overseas enterprise.

This biography of the first foreign-born samurai and his journey from Africa to Japan is “a readable, compassionate account of an extraordinary life” (The Washington Post). When Yasuke arrived in Japan in the late 1500s, he had already traveled much of the known world. Kidnapped as a child, he had ended up a servant and bodyguard to the head of the Jesuits in Asia, with whom he traversed India and China learning multiple languages as he went. His arrival in Kyoto, however, literally caused a riot. Most Japanese people had never seen an African man before, and many of them saw him as the embodiment of the black-skinned Buddha. Among those who were drawn to his presence was Lord Nobunaga, head of the most powerful clan in Japan, who made Yasuke a samurai in his court. Soon, he was learning the traditions of Japan’s martial arts and ascending the upper echelons of Japanese society. In the four hundred years since, Yasuke has been known in Japan largely as a legendary, perhaps mythical figure. Now African Samurai presents the never-before-told biography of this unique figure of the sixteenth century, one whose travels between countries and cultures offers a new perspective on race in world history and a vivid portrait of life in medieval Japan. “Fast-paced, action-packed writing. . . . A new and important biography and an incredibly moving study of medieval Japan and solid perspective on its unification. Highly recommended.” —Library Journal (starred review) “Eminently readable. . . . a worthwhile and entertaining work.” —Publishers Weekly “A unique story of a unique man, and yet someone with whom we can all identify.” —Jack Weatherford, New York Times–bestselling author of Genghis Khan

The East India Company, founded in London in 1600, was originally a spice trading organisation. But its governors soon began to think bigger. After a decade, they started to plan voyages to more fabulous places, notably India and Japan. Rich in silver, Japan was a desirable trading partner; crucially, it was also cold in winter. England's main export was woollen cloth, which would not sell in hot places, so the Company envisaged adding to its spice runs by sailing back and forth to Japan, exchanging wool for silver. Maps suggested that this could be done quickly, above Russian. But these maps also made Japan twenty times too large, the size of India in fact. Knowing the Spanish and Portuguese had preceded them, the Company prepared a special present for its first extended sailing to India and Japan. In the end, the Company missed India, but got to Japan in 1613. The Shogun, the military dictator of Japan, was presented with a silver telescope in the name of King James. It was the first telescope ever to leave Europe and the first made as a presentation item. Before this initial ship had even returned, the Company dispatched another, named the New Year's Gift, with an equally stunning cargo: almost 100 oil paintings. These would be given and sold to the Indian and Japanese courts. This book looks at the formation and history of the Company, but mostly examines the meaning of these two extraordinary cargoes. What were they supposed to mean, and what effect did they have on quizzical Asian rulers?

The East India Company, founded in London in 1600, was the world's biggest trading organization until the twentieth century. It was originally a spice trading organization, and its existence was precarious in its early years. But its governors soon began to think bigger. A decade after its foundation, they started to plan voyages to more adventurous places, notably Japan. Japan had silver, was cold in winter, and had no sheep, so was a perfect market for England's main export, woollen cloth. The Company planned to add to its spice-runs, sailing back and forth to Japan, exchanging wool for silver. This could be done quickly and easily, over the top of Russia - or so the maps of the day suggested (these same maps also showed Japan twenty times too large, about the size of India). Knowing the Spanish and Portuguese had got there before them, the Company prepared a special present to impress and win over their Japanese hosts. They chose as their first gift a silver telescope. The expedition carrying the telescope departed in 1611, and the Shogun was finally presented with the telescope in the name of King James I in 1613. It was the first telescope ever to leave Europe, and the first made as a presentation item. Before this voyage had even returned, the Company had dispatched another with an equally stunning cargo: nearly a hundred oil paintings. This is the story of these two extraordinary cargoes: what they meant for the fortunes of the Company, what the choice of them says about the seventeenth century England from which they came, and what effect they had on the quizzical Asian rulers to whom they were given.

The Inner Consultation, Second Edition sets out the author’s thoughts on how consulting skills, and methods of teaching them, have evolved in the 17 years since the book’s first publication. It also develops the theme of ‘curiosity’ as the key requirement for patient-centred consulting and provides a practical consultation model with five checkpoints to work to, advice for developing skills, and suggestions for doctors to ensure they know the cues in the consultation that require their full attention. All general practitioners, GP registrars, and medical professionals will find this book essential and thought-provoking reading.

In this spirited and irreverent critique of Darwin’s long hold over our imagination, a distinguished philosopher of science makes the case that, in culture as well as nature, not only the fittest survive: the world is full of the “good enough” that persist too. Why is the genome of a salamander forty times larger than that of a human? Why does the avocado tree produce a million flowers and only a hundred fruits? Why, in short, is there so much waste in nature? In this lively and wide-ranging meditation on the curious accidents and unexpected detours on the path of life, Daniel Milo argues that we ask these questions because we’ve embraced a faulty conception of how evolution—and human society—really works. Good Enough offers a vigorous critique of the quasi-monopoly that Darwin’s concept of natural selection has on our idea of the natural world. Darwinism excels in accounting for the evolution of traits, but it does not explain their excess in size and number. Many traits far exceed the optimal configuration to do the job, and yet the maintenance of this extra baggage does not prevent species from thriving for millions of years. Milo aims to give the messy side of nature its due—to stand up for the wasteful and inefficient organisms that nevertheless survive and multiply. But he does not stop at the border between evolutionary theory and its social consequences. He argues provocatively that the theory of evolution through natural selection has acquired the trappings of an ethical system. Optimization, competitiveness, and innovation have become the watchwords of Western societies, yet their role in human lives—as in the rest of nature—is dangerously overrated. Imperfection is not just good enough: it may at times be essential to survival.