The social consequences of anti-parasitic urbanism, as efforts to expunge supposedly biological parasites penalize those viewed as social parasites. According to French philosopher Michel Serres, ordered systems are founded on the pathologization of parasites, which can never be fully expelled. In Paris and the Parasite, Macs Smith extends Serres's approach to Paris as a mediatic city, asking what organisms, people, and forms of interference constitute its parasites. Drawing on French poststructuralist theory and philosophy, media theory, the philosophy of science, and an array of literary and cultural sources, he examines Paris and its parasites from the early nineteenth century to today, focusing on the contemporary city. In so doing, he reveals the social consequences of anti-parasitic urbanism.

The social consequences of anti-parasitic urbanism, as efforts to expunge supposedly biological parasites penalize those viewed as social parasites. According to French philosopher Michel Serres, ordered systems are founded on the pathologization of parasites, which can never be fully expelled. In Paris and the Parasite, Macs Smith extends Serres's approach to Paris as a mediatic city, asking what organisms, people, and forms of interference constitute its parasites. Drawing on French poststructuralist theory and philosophy, media theory, the philosophy of science, and an array of literary and cultural sources, he examines Paris and its parasites from the early nineteenth century to today, focusing on the contemporary city. In so doing, he reveals the social consequences of anti-parasitic urbanism.

Wilson has blended H.P. Lovecraft's dark vision with his own revolutionary philosophy and unique narrative powers to produce a stunning, high-tension story of vaulting imagination. A professor makes a horrifying discovery while excavating a sinister archaeological site. For over 200 years, mind parasites have been lurking in the deepest layers of human consciousness, feeding on human life force and steadily gaining a foothold on the planet. Now they threaten humanity's extinction. They can be fought with one weapon only: the mind, pushed to--and beyond--its limits. Pushed so far that humans can read each other's thoughts, that the moon can be shifted from its orbit by thought alone. Pushed so that man can at last join battle with the loathsome parasites on equal terms.

FROM THE BESTSELLING AUTHOR OF REBECCA 'One of the last century's most original literary talents' DAILY TELEGRAPH 'Wickedly readable . . . every woman instinctively wants to read her' NEW YORK TIMES BOOK REVIEW ' Somehow more personal than Daphne du Maurier's other novels' KIRKUS REVIEWS 'When people play the game: Name three or four persons whom you would choose to have with you on a desert island - they never choose the Delaneys. They don't even choose us one by one as individuals. We have earned, not always fairly we consider, the reputation of being difficult guests . . . ' Maria, Niall and Celia have grown up in the shadow of their famous parents. Their father is a flamboyant singer and their mother is a talented dancer. Now pursuing their own creative dreams, all three siblings feel an undeniable bond, but it is Maria and Niall who share the secret of their parents' pasts. Alternately comic and poignant, The Parasites is based on the artistic milieu its author knew best and draws the reader effortlessly into that magical world.

Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.

Despite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African children less than 5 years of age. The infection starts when mosquitoes transmit small numbers of parasites into the skin. From here, the parasites travel with the bloodstream to the liver where they undergo an initial round of replication and maturation to the next developmental stage that infects red blood cells. A vaccine capable of blocking the clinically silent liver phase of the Plasmodium life cycle would prevent the subsequent symptomatic phase of this tropical disease, including its frequently fatal manifestations such as severe anemia, acute lung injury, and cerebral malaria. Parasitologists, immunologists, and vaccinologists have come to appreciate the complexity of the adaptive immune response against the liver stages of this deadly parasite. Lymphocytes play a central role in the elimination of Plasmodium infected hepatocytes, both in humans and animal models, but our understanding of the exact cellular interactions and molecular effector mechanisms that lead to parasite killing within the complex hepatic microenvironment of an immune host is still rudimentary. Nevertheless, recent collaborative efforts have led to promising vaccine approaches based on liver stages that have conferred sterile immunity in humans – the University of Oxford's Ad prime / MVA boost vaccine, the Naval Medical Research Center’s DNA prime / Ad boost vaccine, Sanaria Inc.'s radiation-attenuated whole sporozoite vaccine, and Radboud University Medical Centre’s and Sanaria's derived chemoprophylaxis with sporozoites vaccines. The aim of this Research Topic is to bring together researchers with expertise in malariology, immunology, hepatology, antigen discovery and vaccine development to provide a better understanding of the basic biology of Plasmodium in the liver and the host’s innate and adaptive immune responses. Understanding the conditions required to generate complete protection in a vaccinated individual will bring us closer to our ultimate goal, namely to develop a safe, scalable, and affordable malaria vaccine capable of inducing sustained high-level protective immunity in the large proportion of the world’s population constantly at risk of malaria.

Hymenoptera. Diptera. Lepidoptera. Strepsiptera. Coleoptera. Hemiptera. Thysanoptera. Trichoptera. Mecoptera. Plecoptera. Neuroptera. Odonata. Corrodentia. Orthoptera. Dermaptera. Thysanura.