This monograph presents a comprehensive and up-to-date account of the developments in optimality aspects of crossover designs. Crossover designs are immensely useful in various areas of human investigation including agriculture, animal nutrition, clinical trials, pharmaceutical studies, biological assays, weather modification experiments, sensory evaluation of food products and learning experiments. Research on the optimality aspects of crossover designs has developed only in the last three decades, and it has now emerged as a potential field for further investigation. This book is the first comprehensive treatise on this subject. It covers optimal crossover designs at length by consolidating vast amounts of material from the literature, and includes many recent and deep results. It is expected that this book will not only provide a one-stop reference for the available results, but also encourage further research in this area of substantial practical relevance.

The Design of Active Crossovers is a unique guide to the design of high-quality circuitry for splitting audio frequencies into separate bands and directing them to different loudspeaker drive units specifically designed for handling their own range of frequencies. Traditionally this has been done by using passive crossover units built into the loudspeaker boxes; this is the simplest solution, but it is also a bundle of compromises. The high cost of passive crossover components, and the power losses in them, means that passive crossovers have to use relatively few parts. This limits how well the crossover can do its basic job. Active crossovers, sometimes called electronic crossovers, tackle the problem in a much more sophisticated manner. The division of the audio into bands is performed at low signal levels, before the power amplifiers, where it can be done with much greater precision. Very sophisticated filtering and response-shaping networks can be built at comparatively low cost. Time-delay networks that compensate for phyical misalignments in speaker construction can be implemented easily; the equivalent in a passive crossover is impractical because of the large cost and the heavy signal losses. Active crossover technology is also directly applicable to other band-splitting signal-processing devices such as multi-band compressors. The use of active crossovers is increasing. They are used by almost every sound reinforcement system, by almost every recording studio monitoring set-up, and to a small but growing extent in domestic hifi. There is a growing acceptance in the hifi industry that multi-amplification using active crossovers is the obvious next step (and possibly the last big one) to getting the best possible sound. There is also a large usage of active crossovers in car audio, with the emphasis on routing the bass to enormous low-frequency loudspeakers. One of the very few drawbacks to using the active crossover approach is that it requires more power amplifiers; these have often been built into the loudspeaker, along with the crossover, and this deprives the customer of the chance to choose their own amplifier, leading to resistance to the whole active crossover philosophy. A comprehensive proposal for solving this problem is an important part of this book. The design of active crossovers is closely linked with that of the loudspeakers they drive. A chapter gives a concise but complete account of all the loudspeaker design issues that affect the associated active crossover. This book is packed full of valuable information, with virtually every page revealing nuggets of specialized knowledge never before published. Essential points of theory bearing on practical performance are lucidly and thoroughly explained, with the mathematics kept to an essential minimum. Douglas' background in design for manufacture ensures he keeps a wary eye on the cost of things. Features: Crossover basics and requirements The many different crossover types and how they work Design almost any kind of active filter with minimal mathematics Make crossover filters with very low noise and distortion Make high-performance time-delay filters that give a constant delay over a wide range of frequency Make a wide variety of audio equaliser stages: shelving, peaking and notch characteristics All about active crossover system design for optimal noise and dynamic range There is a large amount of new material that has never been published before. A few examples: using capacitance multipliers in biquad equalisers, opamp output biasing to reduce distortion, the design of NTMTM notch crossovers, the design of special filters for filler-driver crossovers, the use of mixed capacitors to reduce filter distortion, differentially elevated internal levels to reduce noise, and so on. Douglas wears his learning lightly, and this book features the engaging prose style familiar from his other books The Audio Power Amplifier Design Handbook, Self on Audio, and the recent Small Signal Audio Design.

This monograph presents a comprehensive and up-to-date account of the developments in optimality aspects of crossover designs. Crossover designs are immensely useful in various areas of human investigation including agriculture, animal nutrition, clinical trials, pharmaceutical studies, biological assays, weather modification experiments, sensory evaluation of food products and learning experiments. Research on the optimality aspects of crossover designs has developed only in the last three decades, and it has now emerged as a potential field for further investigation. This book is the first comprehensive treatise on this subject. It covers optimal crossover designs at length by consolidating vast amounts of material from the literature, and includes many recent and deep results. It is expected that this book will not only provide a one-stop reference for the available results, but also encourage further research in this area of substantial practical relevance.

Translating laboratory discoveries into successful therapeutics can be difficult. Clinical Trials in Neurology aims to improve the efficiency of clinical trials and the development of interventions in order to enhance the development of new treatments for neurologic diseases. It introduces the reader to the key concepts underpinning trials in the neurosciences. This volume tackles the challenges of developing therapies for neurologic disorders from measurement of agents in the nervous system to the progression of clinical signs and symptoms through illustrating specific study designs and their applications to different therapeutic areas. Clinical Trials in Neurology covers key issues in Phase I, II and III clinical trials, as well as post-marketing safety surveillance. Topics addressed include regulatory and implementation issues, outcome measures and common problems in drug development. Written by a multidisciplinary team, this comprehensive guide is essential reading for neurologists, psychiatrists, neurosurgeons, neuroscientists, statisticians and clinical researchers in the pharmaceutical industry.

This book primarily addresses the optimality aspects of covariate designs. A covariate model is a combination of ANOVA and regression models. Optimal estimation of the parameters of the model using a suitable choice of designs is of great importance; as such choices allow experimenters to extract maximum information for the unknown model parameters. The main emphasis of this monograph is to start with an assumed covariate model in combination with some standard ANOVA set-ups such as CRD, RBD, BIBD, GDD, BTIBD, BPEBD, cross-over, multi-factor, split-plot and strip-plot designs, treatment control designs, etc. and discuss the nature and availability of optimal covariate designs. In some situations, optimal estimations of both ANOVA and the regression parameters are provided. Global optimality and D-optimality criteria are mainly used in selecting the design. The standard optimality results of both discrete and continuous set-ups have been adapted, and several novel combinatorial techniques have been applied for the construction of optimum designs using Hadamard matrices, the Kronecker product, Rao-Khatri product, mixed orthogonal arrays to name a few.

Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages. * Comprehensive coverage of the design and analysis of cross-over trials. * Each technique is carefully explained and the mathematics is kept to a minimum. * Features many real and original examples, taken from the author's vast experience. * Includes discussion of analysis using SAS, S-Plus and, GenStat, StatXact and Excel. * Written in a style suitable for statisticians and physicians alike. * Computer programs to accompany the examples in the book can be downloaded from the Web Primarily aimed at statisticians and researchers working in the pharmaceutical industry, the book will also appeal to physicians involved in clinical research and students of medical statistics.

The first edition of Design and Analysis of Cross-Over Trials quickly became the standard reference on the subject and has remained so for more than 12 years. In that time, however, the use of cross-over trials has grown rapidly, particularly in the pharmaceutical arena, and researchers have made a number of advances in both the theory and methods applicable to these trials. Completely revised and updated, the long-awaited second edition of this classic text retains its predecessor's careful balance of theory and practice while incorporating new approaches, more data sets, and a broader scope. Enhancements in the second edition include: A new chapter on bioequivalence Recently developed methods for analyzing longitudinal continuous and categorical data Real-world examples using the SAS system A comprehensive catalog of designs, datasets, and SAS programs available on a companion Web site at www.crcpress.com The authors' exposition gives a clear, unified account of the design and analysis of cross-over trials from a statistical perspective along with their methodological underpinnings. With SAS programs and a thorough treatment of design issues, Design and Analysis of Cross-Over Trials, Second Edition sets a new standard for texts in this area and undoubtedly will be of direct practical value for years to come.

This carefully edited collection synthesizes the state of the art in the theory and applications of designed experiments and their analyses. It provides a detailed overview of the tools required for the optimal design of experiments and their analyses. The handbook covers many recent advances in the field, including designs for nonlinear models and algorithms applicable to a wide variety of design problems. It also explores the extensive use of experimental designs in marketing, the pharmaceutical industry, engineering and other areas.

Experiments in the field and in the laboratory cannot avoid random error and statistical methods are essential for their efficient design and analysis. Authored by leading experts in key fields, this text provides many examples of SAS code, results, plots and tables, along with a fully supported website.