Designing an efficient imaging system for biomedical optics requires a solid understanding of the special requirements of the optical systems for biomedical imaging and the optical components used in the systems. However, a lack of reference books on optical design (imaging and illumination) for biomedical imaging has led to some inefficient systems. This book fills the gap between biomedical optics and optical design by addressing the fundamentals of biomedical optics and optical engineering, and biomedical imaging systems. The first half provides a brief introduction to biomedical optics and then covers the fundamentals of optics, optical components, light sources, detectors, optical imaging system design, and illumination system design. This also includes important issues related to biomedical imaging, such as autofluorescence from optical materials. The second half of the text covers various biomedical imaging techniques and their optical systems, along with design examples.

This book provides an introduction to design of biomedical optical imaging technologies and their applications. The main topics include: fluorescence imaging, confocal imaging, micro-endoscope, polarization imaging, hyperspectral imaging, OCT imaging, multimodal imaging and spectroscopic systems. Each chapter is written by the world leaders of the respective fields, and will cover: principles and limitations of optical imaging technology, system design and practical implementation for one or two specific applications, including design guidelines, system configuration, optical design, component requirements and selection, system optimization and design examples, recent advances and applications in biomedical researches and clinical imaging. This book serves as a reference for students and researchers in optics and biomedical engineering.

This tutorial explains the human eye, its function, and performance limits from the perspective of an experienced optical engineer and lens designer. It is concise and readable, with examples and data, and is intended for students, practicing engineers, and technology users.

Prof. Boudoux's book covers a comprehensive range of topics in biomedical optics and biophotonics. The organization of the material is well thought out, starting off with a toolbox of essential concepts that are general and yet detailed enough for a broad range of student backgrounds. The heart of the book covers the essential topics of tissue optics, as well as optical imaging system design concepts. With a well-balanced combination of engineering and physics, this text is an asset for students, and will be a valued long-term reference.

This book provides all the essential and best elements of Kidger's many courses taught worldwide on lens and optical design. It is written in a direct style that is compact, logical, and to the point--a tutorial in the best sense of the word. "I read my copy late last year and read it straight through, cover to cover. In fact, I read it no less than three times. Its elegant expositions, valuable insights, and up-front espousal of pre-design theory make it an outstanding work. It's in the same league with Conrady and Kingslake." Warren Smith.

Knowledge of microscope design is rapidly becoming more important. Microscopes are used in critical applications such as drug development, clinical tests, and genomics. Considerable expertise is required for the evaluation, design, and manufacture of these instruments. Several subsystems must be integrated: the source, the illumination optics, the specimen, the objective lens, the tube optics, and the sensor. The large numerical aperture of a microscope is essential for small spot size and high brightness; however, the large numerical aperture also presents difficult issues in optical design and fabrication. This book provides a foundation for developing design expertise through education, practice, and exploration. It is suitable for lens designers, optical engineers, and students with a basic knowledge of microscope structure.

Biomedical optical imaging is a rapidly emerging research area with widespread fundamental research and clinical applications. This book gives an overview of biomedical optical imaging with contributions from leading international research groups who have pioneered many of these techniques and applications. A unique research field spanning the microscopic to the macroscopic, biomedical optical imaging allows both structural and functional imaging. Techniques such as confocal and multiphoton microscopy provide cellular level resolution imaging in biological systems. The integration of this technology with exogenous chromophores can selectively enhance contrast for molecular targets as well as supply functional information on processes such as nerve transduction. Novel techniques integrate microscopy with state-of-the-art optics technology, and these include spectral imaging, two photon fluorescence correlation, nonlinear nanoscopy; optical coherence tomography techniques allow functional, dynamic, nanoscale, and cross-sectional visualization. Moving to the macroscopic scale, spectroscopic assessment and imaging methods such as fluorescence and light scattering can provide diagnostics of tissue pathology including neoplastic changes. Techniques using light diffusion and photon migration are a means to explore processes which occur deep inside biological tissues and organs. The integration of these techniques with exogenous probes enables molecular specific sensitivity.

Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications reflects upon the increasing role of nanomaterials in biological and medical imaging, presenting a thorough description of current research as well as future directions. With contributions from experts in nanotechnology and imaging from academia, industry, and healthcare, this book provides a comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine. Grouped into three sections, the book: Elucidates all major aspects of nanotechnology and bioimaging Provides comprehensive coverage of the field, ranging from the architectural design of nanomaterials to their broad imaging applications in medicine Written by well-recognized experts in academia, industry, and healthcare, will be an excellence source of reference With a multidisciplinary approach and a balance of research and diagnostic topics, this book will appeal to students, scientiests, and healthcare professionals alike

Based on physical science principles, Quantitative Biomedical Optics covers theory, instrumentation, methods and applications, with practical exercises and problem sets.

The practical, popular 1995 tutorial has been thoroughly revised and updated, reflecting developments in technology and applications during the past decade. New chapters address wave aberrations, thermal effects, design examples, and diamond turning.