This study of Water Supply and Water Pollution Control problem areas in the Ohio River Basin appears as one of a series of cooperating agency reports coordinated to form a broad scale analysis of water and related land resources development of the basin to meet foreseeable short- and long-term needs. The objectives are the determination of overall basin water requirements for municipal and industrial water supply and water quality control and give general appraisals of the probable nature, extent, time of occurrence and possible measures to meet the indicated needs. As a water resources report, the purpose here is to show the possible effect that the available water resources in the area could have on the water supply and quality control demands generated in this basin. The intent is to focus on the utilization of the available water resources to alleviate problem areas that may be anticipated during low flow periods after secondary treatment or equivalent waste reduction processes are applied.