This handbook focuses on the entire development process of biomedical microsystems that promote special interactions with cells. Fundamentals of cell biology and mechanobiology are described as necessary preparatory input for design tasks. Advanced design, simulation, and micro/nanomanufacturing resources, whose combined use enables the development of biomedical microsystems capable of interacting at a cellular level, are covered in depth. A detailed series of chapters is then devoted to applications based on microsystems that offer enhanced cellular control, including microfluidic devices for diagnosis and therapy, cell-based sensors and actuators (smart biodevices), microstructured prostheses for improvement of biocompatibility, microstructured and microtextured cell culture matrices for promotion of cell growth and differentiation, electrophoretic microsystems for study of cell mechanics, microstructured and microtextured biodevices for study of cell adhesion and dynamics, and biomimetic microsystems (including organs-on-chips), among others. Challenges relating to the development of reliable in vitro biomimetic microsystems, the design and manufacture of complex geometries, and biofabrication are also discussed.

While existing books related to DOE are focused either on process or mixture factors or analyze specific tools from DOE science, this text is structured both horizontally and vertically, covering the three most common objectives of any experimental research: * screening designs * mathematical modeling, and * optimization. Written in a simple and lively manner and backed by current chemical product studies from all around the world, the book elucidates basic concepts of statistical methods, experiment design and optimization techniques as applied to chemistry and chemical engineering. Throughout, the focus is on unifying the theory and methodology of optimization with well-known statistical and experimental methods. The author draws on his own experience in research and development, resulting in a work that will assist students, scientists and engineers in using the concepts covered here in seeking optimum conditions for a chemical system or process. With 441 tables, 250 diagrams, as well as 200 examples drawn from current chemical product studies, this is an invaluable and convenient source of information for all those involved in process optimization.

Essential reference for researchers and experts in industry highlighting the rapidly growing field of hydroxyapatite-based catalysts and their application in various chemical processes. Hydroxyapatite (Ca10(PO4)6(OH)2) is the main mineral component of human and animal bones. It is largely applied in the field of biomaterials due to its biocompatibility. Recently, hydroxyapatite-based materials have especially gained a lot of attention by researchers in catalysis, as they are versatile and have shown precious properties of a good catalyst and catalyst support such as excellent ion-exchange capacity, high porosity, very low water solubility, controlled basicity/acidity, and good thermal stability at high temperatures. Design and Applications of Hydroxyapatite-Based Catalysts gives a detailed overview of the synthesis, characterization, and use of hydroxyapatite-based materials in catalysis. It covers synthetic hydroxyapatites (from pure chemicals or waste), natural apatites and materials from eggshells and animal bones. The application of hydroxyapatite-based catalysts in selective oxidation, deoxygenation, selective hydrogenation, dehydrogenation reactions, organic synthesis, as well as reforming processes and production of energy carriers is reviewed. Moreover, electrocatalysis and photocatalysis using hydroxyapatite-based materials are discussed. Kinetic and mechanism studies of various chemical pro-cesses over hydroxyapatite-based catalysts are also presented. This is the first book solely dedicated to hydroxyapatite-based materials and their use in catalysis. Covers synthesis and characterization, surface and structure studies, kinetic and mechanism aspects, and various applications in heterogeneous catalysis, electrocatalysis, and photocatalysis. Aimed at further stimulating research in the field Design and Applications of Hydroxyapatite-Based Catalysts is an indispensable source-of-information for researchers in academia and industry working in catalysis.

This book helps you master critical system analysis and design skills, and shows you how to use digital computer simulation to verify that an analysis is correct and that a design is optimal. This comprehensive resource covers a wide range of essential topics, from matrix, vector and linear equations, noise and clutter generation, Filters (FIR and IIR), and fast Fourier transforms...to ambiguity functions, antennas, target detection, and the Kalman filter...to the Monte Carlo method, constant false alarm rate (CFAR) processing, and moving target indicators (MTI).

This comprehensive introduction to rock mechanics treats the basics of rock mechanics in a clear and straightforward manner and discusses important design problems in terms of the mechanics of materials. This extended third edition includes an additional chapter on Foundations on Jointed Rock. Developed for a complete class in rock engineering, this volume uniquely combines the design of surface and underground rock excavations and addresses: • rock slope stability in surface excavations, from planar block and wedge slides to rotational and toppling failures • shaft and tunnel stability, ranging from naturally-supported openings to analysis and design of artificial support and reinforcement systems • entries and pillars in stratified ground • three-dimensional caverns, with emphasis on cable bolting and backfill • geometry and forces of chimney caving, combination support and trough subsidence • rock bursts and bumps in underground excavations, with focus on dynamic phenomena and on fast and sometimes catastrophic failures. The numerous exercises and examples familiarize the reader with solving basic practical problems in rock mechanics through various design analysis techniques and their applications. Supporting the main text, appendices provide supplementary information about rock, joint, and composite properties, rock mass classification schemes, useful formulas, and an extensive literature list. The large selection of problems at the end of each chapter can be used for home assignment. A solutions manual is available to course instructors. Explanatory and illustrative in character, this volume is suited for courses in rock mechanics, rock engineering and geological engineering design for undergraduate and first year graduate students in mining, civil engineering and applied earth sciences. Moreover, it will form a good introduction to the subject of rock mechanics for earth scientists and engineers from other disciplines.