Nucleic Acids in Chemistry and Biology

Nucleic Acids in Chemistry and Biology
Author :
Publisher : Royal Society of Chemistry
Total Pages : 503
Release :
ISBN-10 : 9781782625773
ISBN-13 : 1782625771
Rating : 4/5 (73 Downloads)

Synopsis Nucleic Acids in Chemistry and Biology by : G Michael Blackburn

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Nucleic Acids in Chemistry and Biology

Nucleic Acids in Chemistry and Biology
Author :
Publisher : Oxford University Press, USA
Total Pages : 556
Release :
ISBN-10 : UOM:39015038595818
ISBN-13 :
Rating : 4/5 (18 Downloads)

Synopsis Nucleic Acids in Chemistry and Biology by : G. Michael Blackburn

Since the discovery of the DNA double helix in 1953, nucleic acids have formed the central theme of much of contemporary molecular science. Recent mastery of nucleic acids synthesis has been the key to the establishment of the biotechnology industry, and our improving knowledge of nucleic acid structures and interactions is considerably influencing the design of novel drugs. The first edition of this book responded to the pressing need for a single volume that integrated the chemistry and biology of the nucleic acids in an introductory yet authoritative text. This second and completely updated edition, which includes a new chapter on techniques applied to nucleic acids, sets the basics of the nucleic acids in the context of the expanding horizons set by modern structural biology, RNA enzymology, drug discovery and biotechnology.

Chemistry and Biology of Artificial Nucleic Acids

Chemistry and Biology of Artificial Nucleic Acids
Author :
Publisher : Wiley-VCH
Total Pages : 0
Release :
ISBN-10 : 3906390675
ISBN-13 : 9783906390673
Rating : 4/5 (75 Downloads)

Synopsis Chemistry and Biology of Artificial Nucleic Acids by : Martin Egli

This is the first book to provide a comprehensive overview of the field of artificial nucleic acids. Covering a tremendous amount of literature on the chemistry, biology, and structure of artificial nucleic acids, it will constitute an invaluable source of information for the specialist and for young researchers interested in starting a career in this fascinating field of research alike. This book combines the contributions of many of the major players in this research field, and covers the synthesis of sugar-, base- and backbone-modified nucleic acids, their structural characteristics studied by X-ray crystallography, and NMR in solution as well as their chemical and biological properties.

Chemistry of Nucleic Acids

Chemistry of Nucleic Acids
Author :
Publisher : Walter de Gruyter GmbH & Co KG
Total Pages : 553
Release :
ISBN-10 : 9783111325927
ISBN-13 : 311132592X
Rating : 4/5 (27 Downloads)

Synopsis Chemistry of Nucleic Acids by : Harri Lönnberg

Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses main aspects of synthesis, hydrolytic stability and solution equilibria of nucleosides, nucleotides and oligonucleotides, as well as synthesis of their structural analogs that are of interest in chemotherapy. In addition, recent achievements in chemistry of catalytic nucleic acids, development of oligonucleotide based drugs and novel strategies for their targeting and delivery are discussed. The central theme always is the correlation of structure and function.

The Chemical Biology of Nucleic Acids

The Chemical Biology of Nucleic Acids
Author :
Publisher : John Wiley & Sons
Total Pages : 595
Release :
ISBN-10 : 9781119957263
ISBN-13 : 1119957265
Rating : 4/5 (63 Downloads)

Synopsis The Chemical Biology of Nucleic Acids by : Günter Mayer

With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Nucleic Acids

Nucleic Acids
Author :
Publisher : Sterling Publishing Company
Total Pages : 854
Release :
ISBN-10 : 0935702490
ISBN-13 : 9780935702491
Rating : 4/5 (90 Downloads)

Synopsis Nucleic Acids by : Victor A. Bloomfield

Providing a comprehensive account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function, this text has been organized to meet the needs of those who have only a basic understanding of physical chemistry and molecular biology.

Advanced Organic Chemistry of Nucleic Acids

Advanced Organic Chemistry of Nucleic Acids
Author :
Publisher : John Wiley & Sons
Total Pages : 603
Release :
ISBN-10 : 9783527615926
ISBN-13 : 352761592X
Rating : 4/5 (26 Downloads)

Synopsis Advanced Organic Chemistry of Nucleic Acids by : Zoe A. Shabarova

Sequencing, cloning, transcription - these are but a few key techniques behind the current breathtaking advances in molecular biology and biochemistry. As these methods continuosly diversify, biochemists need a sound chemical understanding to keep the pace. Chemists beginning working in the molecular biology lab need an introduction to this field from their point of view. This book serves both: it describes most of the known chemical reactions of nucleosides, nucleotides, and nucleic acids in sufficient detail to provide the desired background, and additionally, the fundamental relations between sequence, structure and functionality of nucleic acids are presented. The first edition of this book, which was published in Russian, has immediately become a recognized standard reference. This second, thoroughly revised and updated edition, now published in English, is likely to achieve a similar position in the international scientific community.

Nucleic Acids Chemistry

Nucleic Acids Chemistry
Author :
Publisher : Walter de Gruyter GmbH & Co KG
Total Pages : 380
Release :
ISBN-10 : 9783110639537
ISBN-13 : 311063953X
Rating : 4/5 (37 Downloads)

Synopsis Nucleic Acids Chemistry by : Ramon Eritja

This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.

Current Protocols in Nucleic Acid Chemistry

Current Protocols in Nucleic Acid Chemistry
Author :
Publisher : Current Protocols
Total Pages :
Release :
ISBN-10 : 047124662X
ISBN-13 : 9780471246626
Rating : 4/5 (2X Downloads)

Synopsis Current Protocols in Nucleic Acid Chemistry by : Serge L. Beaucage

Good methods must be reliable, well-tested, and honed to minimize the time and expense required to achieve the desired results. CPNC provides a continuously growing and evolving set of protocols that allows researchers to benefit from the experience of other researchers around the world. The core manual provides a comprehensive set of protocols that have been compiled, revised, and streamlined over the last 6 years. Quarterly updates provide new protocols in emerging areas of research as well as continued advances and new applications for fundamental methods. The book is designed to grow and change with the field of nucleic acid chemistry. Fundamental nucleoside chemistry methods include sugar-base condensation, phosphorylation, and nucleoside protection. Methods for oligonucleotide synthesis include H-phosphonate and phosphoramidite approaches, solid-phase and solution-phase synthesis, large-scale synthesis, synthesis for modified and unmodified oligonucleotides, conjugation of oligonucleotides, synthesis without base protection, and synthesis on microarrays. More specialized synthetic methods include synthesis of biologically active nucleosides and prodrugs. Purification and characterization methods are detailed. Advanced methods include biophysical analysis, combinatorial methods, and nanotechnology. Each protocol includes rationale for choosing appropriate methods, step-by-step procedures, complete recipes, anticipated results, characterization data, and troubleshooting, as well as background and recommended reading. The level of procedural detail is far beyond that found in the research literature, and tips and comments from authors are geared towards ensuring reliable duplication in the laboratory.

Proteins, Enzymes, Genes

Proteins, Enzymes, Genes
Author :
Publisher : Yale University Press
Total Pages : 814
Release :
ISBN-10 : 0300153597
ISBN-13 : 9780300153590
Rating : 4/5 (97 Downloads)

Synopsis Proteins, Enzymes, Genes by :

In this book a distinguished scientist-historian offers a critical account of how biochemistry and molecular biology emerged as major scientific disciplines from the interplay of chemical and biological ideas and practice. Joseph S. Fruton traces the historical development of these disciplines from antiquity to the present time, examines their institutional settings, and discusses their impact on medical, pharmaceutical, and agricultural practice.