This book is a printed edition of the Special Issue "Novel Pharmacological Inhibitors for Bacterial Protein Toxins" that was published in Toxins

This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates. - Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France - 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology - Includes the major toxins of both basic and clinical interest are described in depth - Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology - Evolutionary and functional aspects of bacterial toxins evaluated and summarized - Toxin applications in cell biology presented - Therapy (cancer therapy, dystonias) discussed - Vaccines (native and genetically engineered vaccines) featured - Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.

In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.

Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the need for a thorough understanding of the advantages and risks associated with specific antibiotic choices. This sixth edition of Antimicrobial Chemotherapy continues to be a valuable resource for undergraduates and graduates requiring a thorough grounding in the scientific basis and clinical application of these drugs. This new edition is updated to include the most recently licensed agents, notably in the treatment of viral infections including HIV/AIDS, and contains new guidance on prescribing practice and infection control practices that limit the development and spread of resistant organisms.

In this book, skilled experts provide the most up-to-date, step-by-step laboratory protocols for examining molecular machinery and biological functions of exocytosis and endocytosis in vitro and in vivo. The book is insightful to both newcomers and seasoned professionals. It offers a unique and highly practical guide to versatile laboratory tools developed to study various aspects of intracellular vesicle trafficking in simple model systems and living organisms.

This book examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. By testing new antimicrobial agents and modified existing drugs, the most vulnerable cell processes, such as cell wall and membrane synthesis, DNA replication, RNA transcription and protein synthesis, can be better exploited. This in-depth volume, however, delves even deeper by identifying additional novel cellular targets for these new therapies. The book will provide laboratory investigators with the vital tools they need to test the antimicrobial potential of products and to curb the rise of so many infectious diseases.

Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.

- NEW! Get Ready for the Next Generation NCLEX® Examination! section includes key points, review questions, and case studies with Next Generation NCLEX-format questions to prepare students for the new licensure examination. - NEW! Reorganized chapters break up lengthy content and more logically present pharmacological content by body system or major disorder. - UPDATED! Coverage of newly approved and updated pharmaceutical treatments and drugs prepares students for practice.

**Textbook and Academic Authors Association (TAA) Most Promising New Textbook Award Winner, 2024** Master the pharmacology essentials that health professionals need in practice! Pharmacology Made Simple: An Introduction for the Health Professions makes it easy to understand and apply pharmacology concepts in healthcare careers. Clear and concise, this text uses colorful illustrations, case scenarios, and memory devices to simplify learning and review questions to aid comprehension. An Evolve companion website includes animations of body systems, two practice exams for more self-testing, and printable drug tables. This exciting and practical new text helps you build professional skills and ensures your readiness for the workplace. - Essential information is logically organized and easy to read, focusing on what you need to know. - Engaging, reader-friendly format breaks down pharmacology into manageable chunks of information, accompanied by "flashcard" boxes and memory devices. - Mini case studies in each chapter demonstrate real-world healthcare applications, with scenarios from a variety of health professions settings. - Chapter review questions provide opportunities to assess your comprehension as you move forward. - Full-color illustrations bring complex pharmacology concepts to life with realistic figures and drawings. - Clinical Application and Alert features stress critical thinking and effective job preparation. - Scenario and Alert features stress clinical application and safety. - Focus on patient education helps you learn and practice key skills in professionalism. - Chapter key terms and back-of-book glossary includes pharmacology terms cross-referenced to the chapters in which they are introduced and discussed. - Additional learning resources include a study guide (available separately) and an Evolve companion website with animations, practice exams, and more. - Chapter objectives guide your study by listing the chapter's most important concepts.

With a clear explanation of drug prototypes and how they work, Lehne's Pharmacology for Nursing Care, 10th Edition gives you the background you need to understand drugs currently on the market, and those not yet released. This perennial favorite of students and teachers simplifies complex concepts while distinguishing need-to-know content from the material that’s merely nice to know. The 10th edition includes updated drug content to reflect the very latest FDA approvals, withdrawals, and therapeutic uses, as well as corresponding updated nursing content. It also includes an updated prototype drugs section, summarizing their major uses, and an updated table detailing care throughout the lifespan of the patient. Additionally, each chapter ends with a nursing implications summary to help you fully understand the material and apply it to clinical nursing practice. Prototype Drugs features serve as a quick-reference learning aid so you can apply your understanding to related drugs currently on the market as well as drugs that will be released in the future. UNIQUE! Engaging writing style with clear explanations makes difficult pharmacology concepts easy to grasp and even enjoyable to learn. Nursing implications of drug therapy are integrated throughout the text to reinforce the integral relationship between drug therapy and nursing care. UPDATED Special Interest Topic boxes focus on currently trending issues in pharmacology, eliminating out-of-date content. Large print highlights essential, need-to-know information, and small print indicates nice-to-know information. QSEN focus includes Patient-Centered Care Across the Life Span features highlighting safe and appropriate patient care during different phases of life. Safety Alert features emphasize the QSEN competency relating to patient safety. Student-friendly features make learning easier with concise drug summary tables, chapter outlines, key points, and a visual guide to the prototype drugs in each class. Concise drug summary tables present detailed information for individual drugs, including drug class, generic and trade names, dosages, routes, and indications. Selected Canadian drug names are indicated with a maple-leaf icon throughout the text. Separate Bioterrorism chapter discusses the clinical manifestations and treatment of biological weapon attacks. NEW! Thoroughly updated drug content reflects the very latest FDA drug approvals, withdrawals, and therapeutic uses, as well as corresponding updated nursing content NEW! Additional images included to accompany difficult concepts. NEW! Inclusion of more student practice questions provide additional help for learning the material.