Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.

A comprehensive and practical manual describing the manifestations, pathophysiology and treatments for non-motor Parkinson's Disease. Topics covered in depth include autonomic and sexual dysfunction, mood disorders, sleep disturbances and drug-induced non-motor symptoms.

Parkinson’s Disease and Nonmotor Dysfunction fills a major gap in the current rapidly growing body of knowledge concerning Parkinson’s disease. Drs. Pfeiffer and Bodis-Wollner have correctly perceived that many nonmotor features of Parkinson’s disease are given insufficient attention in the medical literature. Unfortunately, they are often also given insufficient attention by the practicing neurologists who see these patients. As recently pointed out, there is clearly much more to Parkinson’s disease than depletion of the nigrostriatal dopamine system (1). Parkinson’s disease (not just m- tiple system atrophy) is a multisystem disorder, both pathologically and in its clinical manifestations. This is clearly true for the various motor system abnormalities, which are not fully corrected by dopamine replacement therapy strategies, but also for the nonmotor system abnormalities that are the subject of this volume. Although recently there has been increased awareness of the cognitive, psychiatric, and sleep disorders commonly associated with Parkinson’s disease, many of their manifestations remain under-recognized and their importance in managing patients is underestimated. Even less attention is paid to the myriad of other nonmotor disturbances that plague these patients. For example, among the autonomic disorders, although orthostatic hypotension is well recognized, it is usually attributed to dopaminergic medications rather than to effects of the underlying disease. Urologic disorders are also very familiar in these patients, but may not be properly understood or well managed.

This book discusses the link between the brain and the mind. Adopting an evidence-based neuropsychiatry approach while also touching on philosophical aspects, it examines the association between diseases of the brain and mental health, offering comprehensive insights into the emerging new discipline of psychoneuroendocrinoimmunology and its translation to clinical practice. The book particularly focuses on brain plasticity and on explaining the ability of the brain to learn new pathways in everyday situations and at the same time improve creativity. Written by clinicians and leading experts in the field of brain physiology and pathology, this book is a valuable resource for medical professionals and postgraduate students.

This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.

Patients with Parkinson's disease (PD) are known to suffer from motor symptoms of the disease, but they also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment have been developed and are readily available. In contrast, researchers have only recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated by clinicians. The NMS of PD have a significant impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. While some NMS can be improved with currently available treatments, others may be more refractory and will require research into novel (non-dopaminergic) drug therapies for the future. Edited by members of the UK Parkinson's Disease Non-Motor Group (PD-NMG) and with contributions from international experts, this new edition summarizes the current understanding of NMS symptoms in Parkinson's disease and points the way towards future research.

Non-motor Parkinson's: The Hidden Face, Volume 133, the first part of the latest volume in the International Review of Neurobiology series, is an up-to-date, comprehensive textbook addressing the non-motor aspects of Parkinson's disease, a key unmet need. Chapters in this new release include topics such as The hidden face of Parkinson's, JP and non-motor symptoms, Parkinson's: a complex non-motor disease, Neuropathology of NMS of PD, Neurophysiology and animal models related to NMS in PD, Epidemiology of NMS in PD (cohort studies), Genes and NMS in PD, NMS in genetic forms of PD, and Imaging the NMS in PD. Including practical tips for non-specialists and clinical algorithms, this book contains contributions from over 40 opinion leaders in the field of movement disorders, covering the topic from laboratory, to bedside, to caregiver. - Presents a comprehensive textbook on the non motor aspects of Parkinson's disease - Includes practical tips and clinical algorithms, and is the only textbook to bring a holistic approach - Contains contributions from over 40 global opinion leaders in the field of movement disorders - Provides special chapters on exercise, personalized medicine, osteoporosis, genetics, treatment aspects and nutrition

Parkinson's Disease has traditionally been seen as a movement disorder, and diagnosed by the development of tremor. However, we are beginning to understand that the disease manifests itself in many ways, and that earlier diagnosis might be possible through non-tremor symptoms. This textbook aims to tell the full story of non-motor and non-dopaminergic features of Parkinson's Disease.

Handbook of Non-Motor Symptoms in Parkinson’s Disease is designed to provide practical tips and emphasize key priorities for treatment of non-motor aspects of the disorder. The quick-reference handbook format, with key points highlighted by the use of figures and tables, will provide the reader with high-value practical information.

Sexual Dysfunction in Parkinson's Disease, Volume 182, the latest release in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of trending and important topics, including Prevalence, clinical presentations and impact on relationship, Pathophysiology, Scales for assessing sexual dysfunction in Parkinson's disease, Diagnostic work up: Laboratory and biomarkers, Management strategies, ICD DDS and sex dysfunction, Non-motor fluctuations and sex dysfunction, Exploring Sexual Dysfunction in Care Homes, and The impact of non-motor symptoms burden on sexual functions. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review of Neurobiology series - Updated release includes the latest information regarding Sexual Dysfunction in Parkinson's Disease