New Genome Editing Tools And Resources Enabling Gene Discovery And Functional Genomics
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Author |
: Feng Zhang |
Publisher |
: Frontiers Media SA |
Total Pages |
: 80 |
Release |
: 2021-12-01 |
ISBN-10 |
: 9782889717866 |
ISBN-13 |
: 2889717860 |
Rating |
: 4/5 (66 Downloads) |
Synopsis New Genome Editing Tools and Resources: Enabling Gene Discovery and Functional Genomics by : Feng Zhang
Author |
: Marcello Maresca |
Publisher |
: John Wiley & Sons |
Total Pages |
: 355 |
Release |
: 2022-03-15 |
ISBN-10 |
: 9781119671398 |
ISBN-13 |
: 1119671396 |
Rating |
: 4/5 (98 Downloads) |
Synopsis Genome Editing in Drug Discovery by : Marcello Maresca
GENOME EDITING IN DRUG DISCOVERY A practical guide for researchers and professionals applying genome editing techniques to drug discovery In Genome Editing in Drug Discovery, a team of distinguished biologists delivers a comprehensive exploration of genome editing in the drug discovery process, with coverage of the technology’s history, current issues and techniques, and future perspectives and research directions. The book discusses techniques for disease modeling, target identification with CRISPR, safety studies, therapeutic editing, and intellectual property issues. The safety and efficacy of drugs and new target discovery, as well as next-generation therapeutics are also presented. Offering practical suggestions for practitioners and academicians involved in drug discovery, Genome Editing in Drug Discovery is a fulsome treatment of a technology that has become part of nearly every early step in the drug discovery pipeline. Selected contributions also include: A thorough introduction to the applications of CRISPRi and CRISPRa in drug discovery Comprehensive explorations of genome-editing applications in stem cell engineering and regenerative medicine Practical discussions of the safety aspects of genome editing with respect to immunogenicity and the specificity of CRISPR-Cas9 gene editing In-depth examinations of critical socio-economic and bioethical challenges in the CRISPR-Cas9 patent landscape Perfect for academic researchers and professionals in the biotech and pharmaceutical industries, Genome Editing in Drug Discovery will also earn a place in the libraries of medicinal chemists, biochemists, and molecular biologists.
Author |
: Reagan Mudziwapasi |
Publisher |
: CRC Press |
Total Pages |
: 177 |
Release |
: 2021-10-18 |
ISBN-10 |
: 9781000463101 |
ISBN-13 |
: 1000463109 |
Rating |
: 4/5 (01 Downloads) |
Synopsis Genome Editing Tools and Gene Drives by : Reagan Mudziwapasi
Genome-editing methods are becoming routine tools for molecular and cell biologists. Such tools include ZFNs, CRISPR, megaTALs and TALENs. These tools are revolutionizing the creation of precisely manipulated genomes to modify the characteristics of organisms or cells. Additionally, gene drives have altered the way we understand inheritance laws. They give us the ability to have total control of the inheritance of traits of choice and importance. This succinct volume summarizes the history, principles and applications – as well as the advantages and disadvantages – of each of these tools and various kinds of gene drives. The book is part of a program to produce books helpful to students and faculties of science at colleges and universities. This volume in the Pocket Guides to Biomedical Sciences series will help demystify these technologies. The book fills the gap between established conventional methods and the novel and exciting newly introduced tools of genome editing and gene drives. It will help young scientists understand the emerging genome-editing tools and gene drives, thereby promoting related research and adoption. Key Features Extensively reviews the current genome-editing tools and gene drives Clarifies the targeting mechanisms and specificity of genome-editing tools Details many different types of natural and synthetic gene drives Highlights concerns with gene drives and genome-editing tools Related Titles Brown, T. A. Genomes 4 (ISBN 978-0-8153-4508-4) Samuelsson, T. The Human Genome in Health and Disease: A Story in Four Letters (ISBN 978-0-8153-4591-6) Soh, J., et al. Genome Annotation (ISBN 978-1-4398-4117-4)
Author |
: Weikuan Gu |
Publisher |
: John Wiley & Sons |
Total Pages |
: 642 |
Release |
: 2011-03-03 |
ISBN-10 |
: 9781118002179 |
ISBN-13 |
: 1118002172 |
Rating |
: 4/5 (79 Downloads) |
Synopsis Gene Discovery for Disease Models by : Weikuan Gu
This book provides readers with new paradigms on the mutation discovery in the post-genome era. The completion of human and other genome sequencing, along with other new technologies, such as mutation analysis and microarray, has dramatically accelerated the progress in positional cloning of genes from mutated models. In 2002, the Mouse Genome Sequencing Consortium stated that “The availability of an annotated mouse genome sequence now provides the most efficient tool yet in the gene hunter's toolkit. One can move directly from genetic mapping to identification of candidate genes, and the experimental process is reduced to PCR amplification and sequencing of exons and other conserved elements in the candidate interval. With this streamlined protocol, it is anticipated that many decades-old mouse mutants will be understood precisely at the DNA level in the near future.” The implication of such a statement should be similar to the identification of mutated genes from human diseases and animal models, when genome sequencing is completed for them. More than five years have passed, but genes in many human diseases and animal models have not yet been identified. In some cases, the identification of the mutated genes has been a bottleneck, because the genetic mechanism holds the key to understand the basis of the diseases. However, an integrative strategy, which is a combination of genetic mapping, genome resources, bioinformatics tools, and high throughput technologies, has been developed and tested. The classic paradigm of positional cloning has evolved with completely new concepts of genomic cloning and protocols. This book describes new concepts of gene discovery in the post-genome era and the use of streamlined protocols to identify genes of interest. This book helps identify not only large insertions/deletions but also single nucleotide mutations or polymorphisms that regulate quantitative trait loci (QTL).
Author |
: Rodolphe Barrangou |
Publisher |
: Springer Science & Business Media |
Total Pages |
: 300 |
Release |
: 2012-12-13 |
ISBN-10 |
: 9783642346576 |
ISBN-13 |
: 364234657X |
Rating |
: 4/5 (76 Downloads) |
Synopsis CRISPR-Cas Systems by : Rodolphe Barrangou
CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.
Author |
: Yuan-Chuan Chen |
Publisher |
: BoD – Books on Demand |
Total Pages |
: 110 |
Release |
: 2019-05-29 |
ISBN-10 |
: 9781789845082 |
ISBN-13 |
: 1789845084 |
Rating |
: 4/5 (82 Downloads) |
Synopsis Gene Editing by : Yuan-Chuan Chen
Gene-editing technologies (e.g., ZFNs, TALENs, and CRISPRs/Cas9) have been extensively used as tools in basic research. They are further applied in manufacturing agricultural products, food, industrial products, medicinal products, etc. Particularly, the discovery of medicinal products using gene-editing technologies will open a new era for human therapeutics. Though there are still many technical and ethical challenges ahead of us, more and more products based on gene-editing technologies have been approved for marketing. These technologies are promising for multiple applications. Their development and implications should be explored in the broadest context possible. Future research directions should also be highlighted. In this book, the applications, perspectives, and challenges of gene-editing technologies are significantly demonstrated and discussed.
Author |
: Geraldo A. Passos |
Publisher |
: Springer Nature |
Total Pages |
: 216 |
Release |
: 2023-07-24 |
ISBN-10 |
: 9783031333255 |
ISBN-13 |
: 303133325X |
Rating |
: 4/5 (55 Downloads) |
Synopsis Genome Editing in Biomedical Sciences by : Geraldo A. Passos
This volume focuses on applying the Crispr system in editing the genome of human cells (in vitro and in vivo) and model organisms used in biomedical research. With the advent of Crispr technology, genome editing soon became a procedure of great interest to laboratories worldwide due to its relative ease and accuracy. In biomedical sciences, genome editing by Crispr has already enabled the development of new experimental model systems. In medicine, therapeutic alternatives for the genetic "correction" of diseases have already begun to appear. Therefore, the book's purpose is to bring in a single volume, chapters that show the scientific community in biomedicine, medicine, human genetics, oncology, virology, and parasitology, among others, the advances in genomic editing. In a chapter dedicated to the ethical aspects of human genomic editing, we also address what we can and should do with this (bio)technology. The book chapters were written by productive researchers specializing in Crispr genome editing. The chapters cover the concept of Crispr and genome editing and how to use this new methodology in biomedical research and medicine, among other aspects, including the ethical controversy around its use in humans. The writing of the chapters keeps a specialized language intelligible enough for those who want to introduce themselves to the subject.
Author |
: Jennifer A. Doudna |
Publisher |
: HarperCollins |
Total Pages |
: 307 |
Release |
: 2017-06-13 |
ISBN-10 |
: 9780544716964 |
ISBN-13 |
: 0544716965 |
Rating |
: 4/5 (64 Downloads) |
Synopsis A Crack In Creation by : Jennifer A. Doudna
BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY | Finalist for the Los Angeles Times Book Prize “A powerful mix of science and ethics . . . This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”— New York Review of Books Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. “The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas “An invaluable account . . . We owe Doudna several times over.” — Guardian
Author |
: National Academies of Sciences, Engineering, and Medicine |
Publisher |
: National Academies Press |
Total Pages |
: 231 |
Release |
: 2016-08-28 |
ISBN-10 |
: 9780309437875 |
ISBN-13 |
: 0309437873 |
Rating |
: 4/5 (75 Downloads) |
Synopsis Gene Drives on the Horizon by : National Academies of Sciences, Engineering, and Medicine
Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.
Author |
: National Academies of Sciences, Engineering, and Medicine |
Publisher |
: National Academies Press |
Total Pages |
: 201 |
Release |
: 2020-12-18 |
ISBN-10 |
: 9780309676731 |
ISBN-13 |
: 0309676738 |
Rating |
: 4/5 (31 Downloads) |
Synopsis Next Steps for Functional Genomics by : National Academies of Sciences, Engineering, and Medicine
One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.