This practical, comprehensive and highly illustrated book will be invaluable to students and doctors of neurology and internal medicine in Africa.

This Research Topic covers some of the latest research on brain and behavior in health and disease in Africa. With its untapped resources and unique situations, “Neuroscience in Africa” has the potential to contribute to a better understanding of human brain function both in health and disease. The diverse African fauna display a range of specializations in brain structure/function relationships as a result of adaptations to the environment. Exploration of these may lead to insights into coping strategies which could be extrapolated to humans. Africa’s unique flora is being investigated for anti-inflammatory, antinociceptive, antioxidant, antiepileptogenic and neuroprotective properties to determine its potential for use in the treatment of human brain disorders. There is also research on neurodegenerative and infectious diseases, not only common to the global world, but also neglected tropical diseases and conditions which provide unique avenues of investigations in basic and translational neuroscience on highly debilitating disorders - and on the effects of pathogens and environmental toxins.

Although there are several gaps in understanding the many issues related to neurological disorders, we know enough to be able to shape effective policy responses to some of the most common. This book describes and discusses the increasing public health impact of common neurological disorders such as dementia, epilepsy, headache disorders, multiple sclerosis, neuroinfections, neurological disorders associated with malnutrition, pain associated with neurological disorders, Parkinson's disease, stroke and traumatic brain injuries. It provides information and advice on public health interventions that may reduce their occurrence and consequences, and offers health professionals and planners the opportunity to assess the burden caused by these disorders. The clear message that emerges is that unless immediate action is taken globally, the neurological burden is likely to become an increasingly serious and unmanageable.

Written by field experts, Neuroimmunology in Clinical Practice fills a void in traditional neuroimmunology literature, which tends to cover the discipline’s scientific aspects with little emphasis on clinical applications. This unique book is essential reading in clinical neuroimmunology. Written by field experts this book provides a comprehensive description of immune mediated neurological disorders complemented with the most pertinent and up to date scientific data Covers inflammatory demyelination in the central nervous system, autoimmune diseases of the peripheral nervous system and the muscle, and disorders of the central and peripheral nervous systems Fills a gap in existing neuroimmunology literature by focusing on clinical applications

Neuroimmunology, the latest volume in the Contemporary Neurology Series, provides a practical, clinical, and scientific background on a diverse group of neurological disorders in this rapidly expanding field. The clinical chapters cover epidemiology, pathology, pathogenesis, and pathophysiology of the different diseases along with clinical presentation, diagnostic testing, differential diagnosis, and treatment. All are presented in an accessible, practical format, making this volume a valuable resource for physicians and other healthcare providers that will care for persons with neuroimmunologic diseases.

A truly global textbook for neurological practice Neurological disease varies in its presentations and pathologythroughout the world. In today’s interconnected world,neurologists need to be aware that patients can come from anywherein the world with presentations and pathologies that may not betypical of their local context. This unique textbook deals with the differences in etiology,genetics, age of onset and clinical presentations of neurologicaldisease internationally. This is the first book to take a trulyglobal approach to neurological illness. Consisting of 22 sections and 173 chapters with contributionsfrom experts in many countries, it serves as an invaluable guidefor physicians to expand their knowledge of different neurologicaldisorders around the world. More importantly it is a definitivesource of practical information to aid diagnosis and treatment.

This book provides a clinical focus on neuroinflammatory diseases as well as a review in pathophysiology and treatment approaches. Organized into six parts, the book begins with a basic review of the immune system and concepts for learning and treating neuroimmune conditions. The next four sections cover specific subfields of neuroimmunology and autoimmune neurology - the clinical and diagnostic features of multiple sclerosis, other autoimmune conditions of the central nervous system, autoimmune conditions of the peripheral nervous system, and systemic autoimmune conditions that affect the nervous system. To conclude, Section six discusses various clinical approaches to specific presentations in neuroimmunology, including pediatric demyelinating diseases. These sections provide practical clinical information to improve the reader’s knowledge in this complex field. The chapters are written by world renown authors with extensive knowledge to help provide up to date information. The full scope of autoimmune neurology is discussed, which is a unique feature of this book. Neuroimmunology serves as a resource for those in training including residents and fellows to provide clear clinical reasoning and background in a rapidly advancing field.

Parasitic infections remain a significant cause of morbidity and mortality in the world today. Often endemic in developing countries many parasitic diseases are neglected in terms of research funding and much remains to be understood about parasites and the interactions they have with the immune system. This book examines current knowledge about immune responses to parasitic infections affecting humans, including interactions that occur during co-infections, and how immune responses may be manipulated to develop therapeutic interventions against parasitic infection. For easy reference, the most commonly studied parasites are examined in individual chapters written by investigators at the forefront of their field. An overview of the immune system, as well as introductions to protozoan and helminth parasites, is included to guide background reading. A historical perspective of the field of immunoparasitology acknowledges the contributions of investigators who have been instrumental in developing this field of research.

This comprehensive, up-to-date book is designed to make recent developments in neuroimmunology accessible to medical professionals in the field. The field of neuroimmunology is complex and rapidly evolving, especially with the current improvements in targeted biologic therapies. This resource concisely offers clear explanations of these scientific and clinical advancements. Divided into five parts, the book begins with an in-depth introduction to neuroimmunology and the principles of immunotherapy. Section two consists of eight chapters devoted to multiple sclerosis, including discussions on the clinical features of the disease as well as symptom management and diagnosis. Subsequent chapters then dive into other central nervous system inflammatory disorders such as neuromyelitis optica, autoimmune encephalopathies, and immunological aspects of cancer. Following this are two chapters that examine distinct aspects of autoimmune disorders of the peripheral nervous system. Finally, the book closes with a review on the neurologic manifestations, diagnostic approaches and treatments of the various systemic rheumatic diseases. Following its successful predecessor edition, Clinical Neuroimmunology: Multiple Sclerosis and Related Disorders, Second Edition is positioned to be an invaluable asset to neurologists, residents and fellows, internists, and general practitioners who treat patients with neurologic disorders and other systemic autoimmune diseases.