In this issue of Clinics in Perinatology, guest editors Drs. Ravi Mangal Patel and Amy Keir bring their considerable expertise to the topic of Neonatal Transfusion Medicine. Transfusions to neonates convey both benefits and risks, and evidence-based data for possible adverse effects, preterm morbidities, mortality, and neuro-developmental problems associated with transfusions is needed to make decisions for proper care. This issue fills the gap of evidence-based knowledge in order to improve outcomes in patients. - Contains 9 practice-oriented topics including potential mechanisms mediating harm from platelet transfusions in neonates; plasma transfusion in the neonate; neonatal blood banking practices; transfusion in neonatal ECMO; allogenic cord blood transfusion in infants; and more. - Provides in-depth clinical reviews on neonatal transfusion medicine, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Recent advances in neonatal hematology, largely made by the authors of these chapters, are likely to generate wide spread and long-term improvements in outcomes, as well as reductions in costs of care. Publication of these advances in a single volume will facilitate dissemination of these techniques and practices. The advances include neuroprotection from erythropoietic stimulators, improved guidelines for platelet transfusions, evidence-based guidelines for FFP administration, improved diagnostic methods for genetic causes of severe neonatal jaundice, more accurate definitions of hematological perturbations in necrotizing enterocolitis and sepsis, and reduction in transfusions and in IVH rates by cord milking/delayed clamping.

Together with Consulting Editor Dr. William Rayburn, Guest Editors Dr. Cynthia Gyamfi-Bannerman and Dr. Russel Miller have curated a state-of-the-art monograph devoted to Advances in Maternal Fetal Medicine. They have secured expert authors to submit clinical reviews for perinatologists. Specific articles are devoted to the following topics: Advances in delivery management for the preterm fetus (magnesium sulfate, late-preterm antenatal corticosteroids); Approaches to stillbirth prevention; Current preterm birth prevention strategies; Neurological outcomes after fetal therapy for complicated monochorionic twins; Innovations in fetal myelomeningocele (fMMC) repair; An update on biologic agents in pregnancy; Telemedicine in obstetrics; The impact of racial and socioeconomic disparities on obstetrical outcomes; Opioids use and misuse in pregnancy; Advances in statewide and national obstetrical QI collaborations; Optimizing term delivery timing and mode of delivery; Preeclampsia; E-Z infections can be quite challenging: Contemporary understanding of Ebola and Zika virus in pregnancy; and Next-generation genetic testing in obstetrics. Readers will come away with the evidence-based recommendations they need to improve patient outcomes.maternal fetal medicine; fetus; pregnancy;

The Guest Editors have assembled well published authors to present state-of-the-art clinical reviews devoted to resuscitation of the newborn and fetus. Articles are devoted to the following topics: fetal/intrauterine compromise; Cellular biology of end organ injury and strategies to prevent end organ injury; Role of oxygen in the DR; DR management of meconium stained infant; Role of medications in neonatal resuscitation; Delayed cord clamping; Post-resuscitation management; HIE and novel strategies for neuroprotection; Physiology of transition from intrauterine to extrauterine life; Resuscitation of preterm infants: Special considerations; Chest compressions and dysrhythmias in neonates; Resuscitation of infants with prenatally diagnosed anomalies; Ethical issues in neonatal resuscitation; Training programs in neonatal resuscitation: The Neonatal Resuscitation Program and Helping Babies Breathe; and Future of neonatal resuscitation.

The delivery of high quality and equitable care for both mothers and newborns is complex and requires efforts across many sectors. The United States spends more on childbirth than any other country in the world, yet outcomes are worse than other high-resource countries, and even worse for Black and Native American women. There are a variety of factors that influence childbirth, including social determinants such as income, educational levels, access to care, financing, transportation, structural racism and geographic variability in birth settings. It is important to reevaluate the United States' approach to maternal and newborn care through the lens of these factors across multiple disciplines. Birth Settings in America: Outcomes, Quality, Access, and Choice reviews and evaluates maternal and newborn care in the United States, the epidemiology of social and clinical risks in pregnancy and childbirth, birth settings research, and access to and choice of birth settings.

In this issue of Clinics in Perinatology, guest editors Drs. Ravi Mangal Patel and Amy Keir bring their considerable expertise to the topic of Neonatal Transfusion Medicine. Transfusions to neonates convey both benefits and risks, and evidence-based data for possible adverse effects, preterm morbidities, mortality, and neuro-developmental problems associated with transfusions is needed to make decisions for proper care. This issue fills the gap of evidence-based knowledge in order to improve outcomes in patients. Contains 9 practice-oriented topics including potential mechanisms mediating harm from platelet transfusions in neonates; plasma transfusion in the neonate; neonatal blood banking practices; transfusion in neonatal ECMO; allogenic cord blood transfusion in infants; and more. Provides in-depth clinical reviews on neonatal transfusion medicine, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This book covers the latest developments in the understanding and treatment of traumatic brain injury. Various world experts authored the chapters that comprise a wealth of updated information on intracranial pressure; monitoring and diagnostic methods; neuroinflammatory responses in traumatic brain injury; cerebral palsy and Covid-19–related brain disorder; pathogenesis and prevention of fetal, neonatal, infant, and child brain injury; hyperbaric oxygenation treatment; the engineering and modeling of head injury; systematic review on early-tracheostomy; intracranial aneurysm in tuberous sclerosis complex; and the neurobehavioral and cognitive aspects of brain injury. With these complex topics, every clinician, scientist, and researcher will find this book invaluable in understanding the latest improvements and advances in the diagnosis and treatment of traumatic brain injury.

Offering a concise overview of transfusion medicine, including best practices for specific clinical settings, this practical resource by Dr. Robert W. Maitta covers the key information you need to know. Holistic, multidisciplinary coverage and a succinct, easy-to-read format make it essential reading for transfusion specialists, as well as practitioners in other specialties whose patients undergo blood transfusions. - Covers the latest advancements in transfusion therapies, hematopoietic stem cells, infectious and non-infectious complications of transfusions, and future directions in transfusion medicine. - Discusses special populations, including organ transplant patients; pediatric, obstetric, and geriatric patients; and patients undergoing emergency care. - Consolidates fundamental clinical concepts and current practice of transfusion medicine into one convenient resource.

Handbook of Transfusion Medicine

Patient Blood Management (PBM) is an innovative clinical concept that aims to reduce the need for allogenic blood transfusions, cut health-care costs, and avert or correct the risk factors related to blood transfusion, thus minimizing the rate of side effects and complications. This comprehensive hands-on volume offers a three-point approach for the implementation of PBM to improve patient outcome, focusing on how to prevent or treat anemia, reduce blood loss, and increase anemia tolerance. The book also goes beyond preoperative PBM, with detailed accounts of coagulation disorder management and the administration of coagulation products and platelet concentrates. Special Features: Presents a clear three-pillar strategy for the application of PBM: diagnosis and treatment of anemia, reduction of peri-interventional blood loss, and optimization of the tolerance to anemia in the everyday clinical setting Covers issues such as PBM during surgery, requirements for modern transfusion medicine, ordering blood products, the role of pre-anesthesia clinics, benchmarking processes, and potential implications of PBM in the public health sector Overview of research in PBM including landmark studies and current clinical trials Boxes in each chapter highlighting key information, core statements, and summaries A multidisciplinary and international team of contributors experienced in PBM Patient Blood Management is a guide for clinicians and residents whose patients are at risk for anemia, coagulation disorders, or severe blood loss. Anesthesiologists, surgeons, and specialists involved in the use of blood and blood products can use the book for quick reference or to learn more about a leading-edge concept for optimizing patient safety and improving outcome.